DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLC9

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_190306.2	Gene:	PLC9 / 823875	AraportID:	AT3G47220	Length:	531	Species:	Arabidopsis thaliana

Alignment Length:	742	Identity:	156/742 - (21%)
Similarity:	254/742 - (34%)	Gaps:	280/742 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QVDKSGRIP-------------VKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFE 211
            |.::.||:|             :.|::..|.:..:    .||..|..||.:.:
plant    12 QANQPGRVPNYFRNKYHGYDDDMPNLLPTFIKLLD----TEKDEDGAGLNAAE------------ 60

  Fly   212 DFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRD-PRLNEILY------PYAN 269
                         :::|...|      |||    .:::|.|.|..: |.|||.|:      |.::
plant    61 -------------QIDRELKS------RKC----DILKFRNLTILELPHLNEFLFSTELNPPISD 102

  Fly   270 PARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHN 334
            ..|.:                                            ||:.|:|||||::|..
plant   103 QVRHR--------------------------------------------DMNAPLSHYFIHTSLK 123

  Fly   335 TYLTGHQLTGK-SSVEIYRQCLLAGCRCVELDF-------------WNGRTEEPVIVHGYTFVPE 385
            :|.||:.:.|: .|:|.....|..|.|.||||.             ||  .|:|:.:
plant   124 SYFTGNNVFGRLYSIEPIIDALKQGVRVVELDLLPFGKDGICVRPKWN--FEKPLEL-------- 178

  Fly   386 IFAKDVLEAIAESAF-KTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNM 449
               ::.|:||.:.|| .|..||||::.::...|..|:|:.....:.||||:..:    .|.:...
plant   179 ---QECLDAIKQHAFTPTRSYPVIITIKDSLKPDLQSKVTQMIDQTFGDMVYHE----DPQQSLE 236

  Fly   450 DLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHE 514
            :.|.||.|:.||:|.              ::|.        .||..|.:|
plant   237 EFPSPAELQNKILIS--------------RRPP--------TKLLYAKAV--------------- 264

  Fly   515 DGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLP 579
            :.||.                           .:|::.|.|.
plant   265 ENGVE---------------------------LEIQEGSTDK----------------------- 279

  Fly   580 SGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIE 644
                                    ||...:   .|...|.:....:..:.|.:|....  ||.:
plant   280 ------------------------NYQSVV---GFHAVEPRGMLQKALTDDVQQPGWY--ERDV- 314

  Fly   645 FVNYNKHQLSRVYPAGTRFDSS-NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYL 708
             :::.:::..|..|......|: .:.||..|..|.|::||:.|.....:.|..|:|..|...||:
plant   315 -ISFTQNKFLRTRPKKRNLLSNPPYKPQRAWMHGAQMIALSRQDDKEKLWLMQGMFRANGGCGYV 378

  Fly   709 LKPEFMRR--SDRRLDPFAESTVDGIIAGTVSITVLSGQ-FLTD--KRANTFVEVDMY------G 762
            .||.|:..  |.....|    |.:.::..|:.:.:..|. ::.|  ||.....:.|:|      |
plant   379 KKPNFLLNAGSSGVFYP----TENPVVVKTLKVKIYMGDGWIVDFKKRIGRLSKPDLYVRISIAG 439

  Fly   763 LPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE----EGGKLIGHRVLPV 823
            :|.|   :|....||::|...|.:.|| |.| .:..|:||.|....|:    ......|...|||
plant   440 VPHD---EKIMNTTVKNNEWKPTWGEE-FTF-PLTYPDLALISFEVYDYEVSTPDYFCGQTCLPV 499

  Fly   824 IGLCPGYRHVNLRSEVGQPIALASLFL 850
            ..|..|.|.|.|..|.|:  |.:|..|
plant   500 SELIEGIRAVPLYDERGK--ACSSTML 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167
		PLN02222	213..850	CDD:177868	144/674 (21%)
		EF-hand_like	225..317	CDD:286375	15/98 (15%)
		PI-PLCc_beta	317..702	CDD:176533	83/400 (21%)
		C2_PLC_like	736..855	CDD:175974	38/128 (30%)
PLC9	NP_190306.2	PLN02223	2..531	CDD:165867	156/742 (21%)
		PI-PLCc_GDPD_SF	106..372	CDD:301322	83/444 (19%)
		C2_PLC_like	402..531	CDD:175974	38/130 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		mtm1043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920