DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLC2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001030660.1	Gene:	PLC2 / 819999	AraportID:	AT3G08510	Length:	581	Species:	Arabidopsis thaliana

Alignment Length:	662	Identity:	186/662 - (28%)
Similarity:	284/662 - (42%)	Gaps:	117/662 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 FYNLYKYLTQRS--EVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKE 275
            |...::|....:  |::.:|:..   |:...|::..|..||...|:..:        |....|:.
plant    12 FRRRFRYTASEAPREIKTIFEKY---SENGVMTVDHLHRFLIDVQKQDK--------ATREDAQS 65

  Fly   276 LIQQYEPNKFNA--QKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            :|     |..::  .:..|.||.|.:||.||:||.:|..|:.  .|||.|:|||||.:.||:|||
plant    66 II-----NSASSLLHRNGLHLDAFFKYLFGDNNPPLALHKVH--HDMDAPISHYFIFTGHNSYLT 123

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFW-NGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            |:||:...|.......|..|.|.:|||.| |...::..::||.|....:.....|:||...||..
plant   124 GNQLSSDCSEVPIIDALKKGVRVIELDIWPNSNKDDIDVLHGMTLTTPVGLIKCLKAIRAHAFDV 188

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK 467
            |:|||:::.|:|..|..|:|:|....||||::|...|:.    |...:.|.|..|:|:|||..|
plant   189 SDYPVVVTLEDHLTPDLQSKVAEMVTEIFGEILFTPPVG----ESLKEFPSPNSLKRRIIISTK- 248

  Fly   468 KHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTG 532
                               |....|    ...|.:..|:                       |..
plant   249 -------------------PPKEYK----EGKDVEVVQK-----------------------GKD 267

  Fly   533 TGSAAGTAGHAPP-LQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAG 596
            .|.........|. :|:.:..:||....:|.|...:||.....       |.||..|......||
plant   268 LGDEEVWGREVPSFIQRNKSEAKDDLDGNDDDDDDDDEDKSKI-------NAPPQYKHLIAIHAG 325

  Fly   597 AEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGT 661
            .....:...::       .:.:|..|.    |..|:|.....::...:.|.:.:|.|.|:||.||
plant   326 KPKGGITECLK-------VDPDKVRRL----SLSEEQLEKAAEKYAKQIVRFTQHNLLRIYPKGT 379

  Fly   662 RFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPF-A 725
            |..|||:.|.:.|:.|.|:||.|.|....::.|..|:|..|...||:.||:.:.:|....|.| .
plant   380 RVTSSNYNPLVGWSHGAQMVAFNMQGYGRSLWLMQGMFRANGGCGYIKKPDLLLKSGSDSDIFDP 444

  Fly   726 ESTVDGIIAGTVSITVLSGQ-FLTDKRANTF---------VEVDMYGLPADTVRKKFRTKTVRDN 780
            ::|:.  :..|:.:||..|: :..|.|...|         ..|.:.|:|.|||.||  |||:.||
plant   445 KATLP--VKTTLRVTVYMGEGWYFDFRHTHFDQYSPPDFYTRVGIAGVPGDTVMKK--TKTLEDN 505

  Fly   781 GMNPLYDEEPFVFK-KVVLPELASIRIAAYE----EGGKLIGHRVLPVIGLCPGYRHVNLRSEVG 840
            .: |.:||   ||: .:.:||||.:|:..:|    |.....|...|||..|..|.|...|.|..|
plant   506 WI-PAWDE---VFEFPLTVPELALLRLEVHEYDMSEKDDFGGQTCLPVWELSEGIRAFPLHSRKG 566

  Fly   841 QPIALASLFLCV 852
            :......|.:.|
plant   567 EKYKSVKLLVKV 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167
		PLN02222	213..850	CDD:177868	185/658 (28%)
		EF-hand_like	225..317	CDD:286375	24/93 (26%)
		PI-PLCc_beta	317..702	CDD:176533	107/386 (28%)
		C2_PLC_like	736..855	CDD:175974	44/132 (33%)
PLC2	NP_001030660.1	PLN02222	1..581	CDD:177868	186/662 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		mtm1043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920