DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcd3

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_690026.2	Gene:	Plcd3 / 72469	MGIID:	107451	Length:	785	Species:	Mus musculus

Alignment Length:	791	Identity:	236/791 - (29%)
Similarity:	353/791 - (44%)	Gaps:	183/791 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 FVNFCC-------TRRDI---------AQLWTDGLIKLAYSL------AQLNGSAIMFLQKAHTK 156
            |...||       .|:::         ||.|..||.||...|      .:|:.....:|.:|.:
Mouse   129 FAPACCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADS- 192

  Fly   157 LCLQVDKSGRIPVKNIIKLFAQNKEDRK-----RVEKALDVTGLPSGKVDSISVSKFQFEDFYNL 216
                 |:..::..|.|..|......|..     |:.|..|.:.  :.:::...:..|
Mouse   193 -----DQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKECDHSN--NERLEGAEIEAF-------- 242

  Fly   217 YKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYE 281
            .:.|.:|.|:|.:|....|..  :.:|.::|:|||.....|.         |..|.|::|||.||
Mouse   243 LRRLLKRPELEEIFRRYSGED--RVLSASELLEFLEDQGEDG---------ATLACAQQLIQTYE 296

  Fly   282 PNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKS 346
            .|:...|...::||||:.||:..:...:..:...:..||.||::||||:||||||||..|:.|.|
Mouse   297 LNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTS 361

  Fly   347 SVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSF 411
            |.|.|.:....||||||||.|.|...||||.||:|...:|..:||::|:.:.||.:|.||||||.
Mouse   362 STEAYIRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVRDHAFTSSPYPVILSL 426

  Fly   412 ENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHH 476
            ||||...|||.:|.:.|.|.||||:.:.|||...|   :||.|..|:.:|::|.||
Mouse   427 ENHCGLEQQAVMARHLRSILGDMLVTQALDSQNPE---ELPSPEQLKGRILVKGKK--------- 479

  Fly   477 HHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAG 541
                     .|||.:                      |||.:.
Mouse   480 ---------LPAARS----------------------EDGRIL---------------------- 491

  Fly   542 HAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEA----------G 596
                              ||.:...|:|                 |:|::..||          .
Mouse   492 ------------------SDREEEEEEE-----------------EEAEEALEAAEQRSRAKQIS 521

  Fly   597 AEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGT 661
            .|:|||..|.......:.:.:....:...:.|..|::|....:|....||.:|..||:||||.|.
Mouse   522 PELSALAVYCCATRLRTLDPSPGPPQSCTVGSLSERKARKFTREAGTSFVRHNTQQLTRVYPLGL 586

  Fly   662 RFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAE 726
            |.:|:|:.||..||:|||||||||||....|.||.|.|..|.:.||:|||.::|:.:...||
Mouse   587 RMNSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDP--- 648

  Fly   727 STVDGIIAGTVSITVLSGQFLTDKRA-------NTFVEVDMYGLPADTVRKKFRTKTVRDNGMNP 784
             ...|....|::|.||:.|.|....|       :..|.|:::|:|.|..:|:  |..|.:||.||
Mouse   649 -ECPGPPRTTLAIQVLTAQQLPKLNAEKPSSIVDPLVRVEIHGVPEDCAQKE--TDYVLNNGFNP 710

  Fly   785 LYDEEPFVFKKVVLPELASIRIAAYE----EGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIAL 845
            .: |:...| ::..|||..:|....:    .....:|...||:..|..||||::|.|:.|..:|.
Mouse   711 CW-EQTLQF-RLRAPELVLVRFVVEDYDTTSPNDFVGQSTLPLSSLKQGYRHIHLLSKDGASLAP 773

  Fly   846 ASLFLCVVVKD 856
            |:||:.:.:::
Mouse   774 ATLFVHIRIQN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	13/52 (25%)
		PLN02222	213..850	CDD:177868	211/657 (32%)
		EF-hand_like	225..317	CDD:286375	26/91 (29%)
		PI-PLCc_beta	317..702	CDD:176533	134/394 (34%)
		C2_PLC_like	736..855	CDD:175974	40/129 (31%)
Plcd3	NP_690026.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		PH_PLC_delta	61..177	CDD:270169	12/47 (26%)
		PH	66..163	CDD:278594	7/33 (21%)
		Substrate binding. /evidence=ECO:0000250	69..97
		EF-hand_10	197..246	CDD:291454	8/58 (14%)
		PLN02228	251..778	CDD:177873	209/645 (32%)
		EF-hand_like	251..332	CDD:286375	26/91 (29%)
		PI-PLCc_delta3	332..627	CDD:176567	134/394 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..517		11/111 (10%)
		C2_PLC_like	656..783	CDD:175974	40/130 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750