DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plce1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_021335822.1	Gene:	plce1 / 568288	ZFINID:	ZDB-GENE-061212-4	Length:	2289	Species:	Danio rerio

Alignment Length:	1329	Identity:	352/1329 - (26%)
Similarity:	530/1329 - (39%)	Gaps:	371/1329 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 SDFVNMTFVNF--------CCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDK 163
            ||.: |:||.|        ..:|:|:.:|:....:..:.|     |...:.|   :|.|.:....
Zfish  1177 SDSI-MSFVEFVELFKSFSIRSRKDLKELFDTYAVPCSRS-----GPESVPL---YTTLRIDDKL 1232

  Fly   164 SGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVER 228
            :|..|   .:.|..:|..|          .||.......:|.::.|..|.......:|..:.||.
Zfish  1233 TGLQP---DLDLLTRNGSD----------LGLFIRTRQQMSENQKQISDAIAAASIVTNGTGVEN 1284

  Fly   229 LFDSIVGNSKRKCMSIAQLVEFLNKTQRDP-RLNEILYPYANPARAKELIQQYEPNKFNAQKGQL 292
            ....::|      ::|:||.:||...||:. ..:|||          .:||::||:....|.|.:
Zfish  1285 SSLGVLG------LAISQLNDFLVNCQREHLSYDEIL----------SIIQKFEPSSNMRQMGWM 1333

  Fly   293 SLDGFLRYLMGDDN--PIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCL 355
            |.:||.|:||..||  .....|:::| |::..|:|:|:|.||||||||||||.|:||||:|.|.|
Zfish  1334 SFEGFARFLMDKDNFASKNEESQVNL-DELQHPLSYYYIESSHNTYLTGHQLKGESSVELYSQVL 1397

  Fly   356 LAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQ 420
            |.|||.||||.|:|....|||.||:|...:|..|||:|||..:||..||.|||||.||||:..||
Zfish  1398 LQGCRSVELDCWDGDDGMPVIYHGHTLTTKIPFKDVVEAINRAAFVNSEMPVILSIENHCSLPQQ 1462

  Fly   421 AKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHH----------HHH 475
            .|:|...:.:||:.|:.|.|..........||.|..||.||::||||...|.          |..
Zfish  1463 RKMAEIFKMVFGEKLVTKFLFESDFADEPLLPSPLQLRGKILLKNKKLKAHQAPVDILKQKAHQL 1527

  Fly   476 HHHKKPAQVG----TPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSA 536
            .|.:..|..|    ||..||        |.:..::......:|      |.::.||..
Zfish  1528 AHMQAQANNGTVSTTPLGNN--------DEEEEEEDEYDYDYE------SLSDADVLN------- 1571

  Fly   537 AGTA--GHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPS---------GNE---PPPE 587
            |.||  |....:...:...|.||.....:|:.|   :|.......|         |.|   |..|
Zfish  1572 ASTASYGQEDNILDDKPEGKSSTEKLQYESNDE---MPKRFKKAGSKGKMFDMELGEEFYLPQNE 1633

  Fly   588 KAQKETEAGAEISALVNYVQPIHF---------SSFENAEKKNR--------------------- 622
            |..:  :...|:|.||.|.|.|.|         .|....::|:|
Zfish  1634 KESR--QIAQELSDLVIYCQAIKFPGLSTLSPSGSGRGKDRKSRKSIFGSAPARGSPGEPVTLVR 1696

  Fly   623 ----------------------------------CYEMSSFDEKQATTLLKERPIEFVNYNKHQL 653
                                              ||.:||.:|..|..|.:....:.:.:...||
Zfish  1697 APGKASLEGIRMNSEDQLCLSPSTSLSSIIRTPKCYHISSVNENAAKRLCRRYSQKLIQHTSCQL 1761

  Fly   654 SRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFM-RRS 717
            .|.|||.||.||:|..|.:||..|.||||||:||.||.||||..:||.|...|::|||..: .||
Zfish  1762 LRTYPAATRIDSANPNPLIFWLHGVQLVALNYQTDDLPMQLNAALFEANGHCGFVLKPPVLWDRS 1826

  Fly   718 ----------DRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN--TFVEVDMYGLPADTVRK 770
                      ||.|:....:        ..::|::|||.:....:|  ..|||::.|:|||:..
Zfish  1827 CPLYQHFYPLDRDLENMTPT--------LYTLTIVSGQNVCPGNSNGSPCVEVEVLGMPADSCH- 1882

  Fly   771 KFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE-EGGKLIGHRVLPVIGLCPGYRHVN 834
             ||||.:..|.:||:::|. |.| .|...:||.:|||..| ...::...|:||:..|..||||:.
Zfish  1883 -FRTKPIHRNTLNPMWNEH-FQF-HVHFEDLAFLRIAVVENNSSQVTAQRILPLKTLRAGYRHLQ 1944

  Fly   835 LRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLT--------- 890
            ||:...:|:.::|||:.....:..|......|..|     :.:| |:|.:|...:|
Zfish  1945 LRNLHNEPLEVSSLFMFSRRTEESPTGGPPSASVL-----FSTE-ERRSVQQHKVTVHGVPGPEP 2003

  Fly   891 ------DEAEALGSADEDL--SKSFVF------VQVGGQKKELRPVESLATSPKHRPSISAAAAM 941
                  ||........:.|  :.||.:      |.:..:||          :|:.||..:....:
Zfish  2004 FTVICVDEFTTAKQLLDSLFPTASFKYMLMEERVSLSKEKK----------APQQRPLANDERLL 2058

  Fly   942 SVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKS 1006
            .:..:....||..|.    |...:.:.|:.   |..||:                |||.:.:..|
Zfish  2059 KLIHSWQPEDGYVGR----IYLKTREQQNC---SEKTSV----------------PLESLEELGS 2100

  Fly  1007 VKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEG----KKPKFAITNKLVKRLSNKSLNCLSP 1067
            :::....::        .||          .||.:.    |.|:::....::::..:|:...||.
Zfish  2101 LEDDTFFVQ--------VHD----------VSPEQPHTVIKAPRYSTAQDIIQQTLSKAKYSLSI 2147

  Fly  1068 HSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKY 1132
            .|.|.      |.|.  ...|....|||           |:...|  ...|:      |.||:
Zfish  2148 LSNPN------PCDY--VLMEELCKDAG-----------GKKSSS--AKPCQ------RVLQD-- 2183

  Fly  1133 HEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKRE 1197
            ||.::.|..:.                 |..|:.                        ::::|.:
Zfish  2184 HECVFQAQSRW-----------------KGAGKF------------------------ILKLKEQ 2207

  Fly  1198 VASSVVERGVAERVRLKQTFDRRTDELQKQHDSV---RNALAEHRSKARQILDKEAESRSCVSSN 1259
            :|.....:||        :|.....:|..:..||   .|:...|||.:..:....||.|
Zfish  2208 LAREDKRKGV--------SFASELRKLTGRSRSVTVNTNSNDTHRSLSLGLKAWMAEGR------ 2258

  Fly  1260 GFLVLFHGPHHHGCTGSGSSALSGNNLTL 1288
                 ...|....| |.|.|||||.:|.|
Zfish  2259 -----LGSPRRSQC-GDGVSALSGWSLPL 2281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	10/45 (22%)
		PLN02222	213..850	CDD:177868	242/745 (32%)
		EF-hand_like	225..317	CDD:286375	28/94 (30%)
		PI-PLCc_beta	317..702	CDD:176533	160/476 (34%)
		C2_PLC_like	736..855	CDD:175974	43/121 (36%)
plce1	XP_021335822.1	RasGEF	483..668	CDD:306970
		EFh_PI-PLCepsilon	1166..1346	CDD:320033	50/206 (24%)
		EF-hand motif	1166..1194	CDD:320033	6/17 (35%)
		putative EF-hand motif	1200..1256	CDD:320033	14/76 (18%)
		EF-hand motif	1268..1308	CDD:320033	12/45 (27%)
		EF-hand motif	1313..1346	CDD:320033	15/42 (36%)
		PI-PLC-Y	1355..1960	CDD:332526	214/643 (33%)
		PI-PLCc_epsilon	1359..1810	CDD:176538	161/477 (34%)
		PLC_epsilon_RA	2106..2205	CDD:176375	28/186 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850