DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plcd4a

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_694028.4	Gene:	plcd4a / 565669	ZFINID:	ZDB-GENE-050208-654	Length:	761	Species:	Danio rerio

Alignment Length:	748	Identity:	249/748 - (33%)
Similarity:	369/748 - (49%)	Gaps:	134/748 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 AQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLC---LQVDKS--GRI---PVKNIIKLFAQNKE 181
            ||.|..|:.||..:|..:...     :|....:|   .:.||:  ||:   .|::::|:...:..
Zfish   118 AQSWIKGIRKLIDNLENMGQR-----EKLDQWICDWFKKADKNRDGRMNFKEVRDLLKMMNVDMN 177

  Fly   182 DRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQ 246
            :...:..........||.::.        ::|...||.||||.::.|:|.....:.::  :::..
Zfish   178 EHHALRLFTMADRSQSGTLED--------DEFVLFYKMLTQREDILRVFQEYSADGQK--LTLKD 232

  Fly   247 LVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAP 311
            |.:||.:.|        |:.......|..||:::||:........::.||||.||...:..|..|
Zfish   233 LKDFLQEEQ--------LHEDGVQQYALNLIERFEPSDTAKMLQAMTFDGFLMYLSSSEGSIFNP 289

  Fly   312 SKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVI 376
            :.|:|..||.||:.||||:|||||||...|:.|.||||.|.:.|..||||||:|.|:|...||::
Zfish   290 AMLELYQDMSQPLCHYFISSSHNTYLLEDQIRGLSSVEGYIRALKRGCRCVEVDCWDGPNGEPIV 354

  Fly   377 VHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLD 441
            .||:||..:||.|||:..:...:||.||||||||.||||:..||..:|.:..:|.||.||...||
Zfish   355 YHGHTFTSKIFFKDVVTVLGNYSFKASEYPVILSIENHCSVEQQKIMAQHLTQILGDKLLKSTLD 419

  Fly   442 SH-PLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQ 505
            .. ||    .||.|..|:.||::|.||                :|
Zfish   420 GKIPL----GLPSPEDLKGKILLKGKK----------------IG-------------------- 444

  Fly   506 QVGLSASHEDG--GVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSED 568
              ||    |||  ||......|:|                                ||.:.::|.
Zfish   445 --GL----EDGMNGVVDDPLMGEV--------------------------------SDEEEATEI 471

  Fly   569 ESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQ 633
            |...:...::...::...::..|      |:|..|.|.:.:|||||:::...::.||:|||.|.:
Zfish   472 EDENHRNNSIRHRSKKSKQRLSK------ELSDCVVYCKSVHFSSFKHSRNHSKFYEISSFTESK 530

  Fly   634 ATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGI 698
            |...::|...|||.:|..|||||||:|.|.|||||.||..||||||:|||||||..:.|.||.|:
Zfish   531 ARKHIREAGAEFVLHNARQLSRVYPSGLRTDSSNFNPQDLWNAGCQIVALNFQTAGVEMDLNDGL 595

  Fly   699 FEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR------ANTFVE 757
            |..|.|.||:|||.|||..:...||......:.....::||.|:|||.|....      .:.||.
Zfish   596 FNQNGRCGYVLKPAFMRNFEEMFDPENPQNREDYKPLSLSIQVISGQQLPKVNIKEGSIIDPFVR 660

  Fly   758 VDMYGLPADTVRKKFRTKTVRDNGMNPL-YDEEPFVFKKVVLPELASIR--IAAYEEGGK--LIG 817
            |:::|:|.|..:::  |:.:.:||.||: ||...|.   :..||||.:|  :..|::..|  .:|
Zfish   661 VEIHGVPLDQAKQE--TRYIDNNGFNPVWYDTLQFT---IHAPELALVRFVVEDYDKTSKNDFVG 720

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            ...||...:.|||||::|.|:.|..|..:|||:
Zfish   721 QFTLPFTCIQPGYRHIHLLSKDGTSIPPSSLFV 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	7/19 (37%)
		PLN02222	213..850	CDD:177868	231/650 (36%)
		EF-hand_like	225..317	CDD:286375	21/91 (23%)
		PI-PLCc_beta	317..702	CDD:176533	148/387 (38%)
		C2_PLC_like	736..855	CDD:175974	43/126 (34%)
plcd4a	XP_694028.4	PH_PLC_delta	24..139	CDD:270169	7/25 (28%)
		PH	32..129	CDD:278594	5/10 (50%)
		EF-hand_7	149..205	CDD:290234	9/63 (14%)
		EF-hand_10	159..208	CDD:291454	8/56 (14%)
		PLN02228	212..753	CDD:177873	224/639 (35%)
		EF-hand_like	213..295	CDD:286375	21/91 (23%)
		PI-PLCc_GDPD_SF	295..599	CDD:301322	148/387 (38%)
		C2_PLC_like	631..758	CDD:175974	43/128 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850