DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plcd3b

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_005156186.1	Gene:	plcd3b / 562569	ZFINID:	ZDB-GENE-081222-2	Length:	769	Species:	Danio rerio

Alignment Length:	816	Identity:	264/816 - (32%)
Similarity:	366/816 - (44%)	Gaps:	187/816 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTD 130
            |:|:    |.|..|::..| .||..|.:.:|:.:                   |...:.||.|..
Zfish    96 TLRN----QAASLPEEQCL-TIVFKGGRKSLDVQ-------------------CDTTEEAQHWVH 136

  Fly   131 GLIKL---AYSLAQ---LNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFA-----QNKEDRK 184
            |:..|   ..::.|   |:.....:|::|      .::..|::..:.:..||.     .|:|...
Zfish   137 GIRTLQGRVNNMTQKEKLDNWIYGYLKQA------DINHDGKMSYEEVQVLFKLVNIDLNEEYAA 195

  Fly   185 RVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKC-MSIAQLV 248
            .:.|          |.|..:..:.:.|:.....:.|.:|.|::.:|.....|.   | :|...|.
Zfish   196 SLFK----------KSDKSADGRLEHEEIELFCRELLRRPELDAVFQQYSANG---CVLSTVDLR 247

  Fly   249 EFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQ-LSLDGFLRYLMGDDNPIMAPS 312
            |||.....|..|          ..|:.||..||.|:: |||.| ::.:||..|::..:|.:..|.
Zfish   248 EFLKDQGEDHTL----------VHAQSLILTYELNEW-AQKNQFMTANGFTMYMLSKENDVYNPD 301

  Fly   313 KLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIV 377
            ...:..||..|:|||||:||||||||..||...|||..|.:.|..||||||||.|:|. :||||.
Zfish   302 HRRVYQDMSHPLSHYFISSSHNTYLTKDQLISDSSVHPYIRALSQGCRCVELDCWDGE-KEPVIY 365

  Fly   378 HGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDS 442
            ||:|...::...||::.|||.||.||.||:|||.||||:..||..:|...|.|.||.||.|||:.
Zfish   366 HGHTLTSKVPFSDVVKIIAEYAFTTSPYPLILSLENHCSVEQQTIMAQQLRSILGDKLLSKPLND 430

  Fly   443 HPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQV 507
            .||:   .||.|..|:.||::|.||
Zfish   431 KPLQ---YLPSPEDLKGKILMKAKK---------------------------------------- 452

  Fly   508 GLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLP 572
                                                   .::.|.|    .|||| |||:|||..
Zfish   453 ---------------------------------------IKVEQDS----SSSDS-SSSDDESKA 473

  Fly   573 NTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKK--NRCYEMSSFDEKQAT 635
            :.        :|.|||  ::.:..:|:|.||.|...:.|..|:.:.||  |   |||||.|..|.
Zfish   474 DC--------KPKPEK--RDCKLSSELSDLVVYTSSVAFKQFDPSAKKAPN---EMSSFSESDAL 525

  Fly   636 TLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFE 700
            .|:||....||.:|..||||:||:|.|..|||:.||..||||||:|||||||....|.||.|.|.
Zfish   526 KLIKESGKLFVRHNSVQLSRIYPSGQRVQSSNYNPQDMWNAGCQIVALNFQTQSEEMDLNRGRFL 590

  Fly   701 YNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKR-----ANTFVEV 758
            .|...||:|||.||.:.|...:|.......|.....::|.|:|.|.|  .||.     .:..|.|
Zfish   591 ANGNCGYVLKPSFMCQPDSEFNPENTGGGPGYNPTLLTIKVISAQQLPKPDKEKLSSIVDPLVWV 655

  Fly   759 DMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFK-KVVLPELASIRIAA----YEEGGKLIGH 818
            .:||.|.|...||  |..:.:||.||.:|   ..|| ::.:|||..||...    |......:|.
Zfish   656 QIYGAPIDNSTKK--THHINNNGFNPRWD---CTFKFQLHVPELVLIRFMVEDHDYTTRNDFLGQ 715

  Fly   819 RVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVV 854
            ..||...|..|||||.|.:..|..|:.:|||:.|.:
Zfish   716 FTLPFPSLRTGYRHVRLLNADGCSISPSSLFIHVKI 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	18/84 (21%)
		PLN02222	213..850	CDD:177868	233/652 (36%)
		EF-hand_like	225..317	CDD:286375	26/93 (28%)
		PI-PLCc_beta	317..702	CDD:176533	151/386 (39%)
		C2_PLC_like	736..855	CDD:175974	45/131 (34%)
plcd3b	XP_005156186.1	PH-like	34..152	CDD:302622	17/79 (22%)
		EF-hand_7	163..215	CDD:290234	10/67 (15%)
		EF-hand_10	172..221	CDD:291454	8/58 (14%)
		EF-hand_like	226..306	CDD:286375	26/93 (28%)
		PLN02952	230..737	CDD:178538	226/626 (36%)
		PI-PLCc_GDPD_SF	306..592	CDD:301322	151/386 (39%)
		C2_PLC_like	624..752	CDD:175974	45/133 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750