DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plcd4b

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_689964.4	Gene:	plcd4b / 561475	ZFINID:	ZDB-GENE-080512-3	Length:	753	Species:	Danio rerio

Alignment Length:	823	Identity:	266/823 - (32%)
Similarity:	380/823 - (46%)	Gaps:	157/823 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL-EEKTVTVCHGSDFVNMTFVNFCCT 120
            |......|:.:..||.|..::          ..||..|.. .::..|:.......|:..|   ..
Zfish    56 NSYSTFSISDVEAVREGHQSE----------ALLGVADEFPPDRCFTLVFRGRKGNLDLV---AE 107

  Fly   121 RRDIAQLWTDGLIKLAYSLAQLNGSAIM------FLQKAHTKLCLQVDKSGRIPVKNIIKLFA-- 177
            ..:.||.|..|:..|..::..::.|..:      :..||..      :|.|||..|...||..
Zfish   108 SAEEAQAWIQGVRGLMENMENMDESTKLDQWISDWFSKADR------NKDGRINFKEAKKLLKMM 166

  Fly   178 ---QNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKR 239
               .|:|....:.|..|.:  .||.::.        ::|...||.||:|.||..||...  :|..
Zfish   167 NIDMNEEHACCLFKMADKS--RSGTLED--------QEFVEFYKMLTERREVLDLFQDY--SSDG 219

  Fly   240 KCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGD 304
            :.:|...|.|||.:.|.:   .|..|.:     |.:||.:|||::.......:|:||||.||...
Zfish   220 QILSQCDLEEFLREEQLE---GESSYEH-----ALQLIDRYEPSETARMNHSMSVDGFLMYLTSP 276

  Fly   305 DNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNG 369
            :..|..|.:..:..||.|.::||:|:|||||||...||.|.||||.|.|.|..||||||:|.|||
Zfish   277 EGSIFNPERQGIFQDMSQSLAHYYISSSHNTYLMEDQLKGPSSVEAYIQALKRGCRCVEVDCWNG 341

  Fly   370 RTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDM 434
            ...|||:.||:||..:|..|||:..||..|||.||||:|:|.||||:..||..:|...|||.|||
Zfish   342 ANGEPVVYHGHTFTSKILLKDVITTIASYAFKASEYPLIISIENHCSVEQQKVMAQQFREILGDM 406

  Fly   435 LLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSV 499
            ||....|:   |.:.:||.|..|:|||::|.||
Zfish   407 LLTSTADT---EVSSELPSPEALKRKILLKGKK-------------------------------- 436

  Fly   500 DAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDS 564
                                                    .||        :|...:...||.|.
Zfish   437 ----------------------------------------IGH--------ESESPTAEVSDEDE 453

  Fly   565 SSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSF 629
            ::|.....:|:.:||:..:...:...||...       :.:.:.:||.|||::....:.||||||
Zfish   454 AAEMNKESSTSESLPADGKKSKQNLCKELSD-------IMFCKSVHFHSFEHSRISAKPYEMSSF 511

  Fly   630 DEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQL 694
            .|.:|....||...:||.:|..||.||||:|.|.||||:.|...|:.|||:|||||||..:.|.|
Zfish   512 SESKARKYSKEAGSDFVLHNTRQLIRVYPSGMRTDSSNYCPVDMWSMGCQIVALNFQTAGMEMDL 576

  Fly   695 NLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN------ 753
            |.|:|..|..|||:||||.:|..:||.||......:.......|:.|:|||.|...:.|
Zfish   577 NDGLFSQNGCSGYVLKPEILRNRERRFDPEKPEEHEDYNPLVFSVKVISGQQLPKLKQNEWSIVD 641

  Fly   754 TFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGK---- 814
            .||.|::||:|.|..:::  ||.:.:||.||.::|.  |...|..||||.:|... |:..|
Zfish   642 PFVRVEIYGVPLDQAKQE--TKYIDNNGFNPYWNES--VQFTVHTPELALVRFVV-EDHDKASRN 701

  Fly   815 -LIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
             .||...||:..:.||||||:|.|:.|..|..:|:|:.:.:.:
Zfish   702 DFIGQYTLPLSCIQPGYRHVHLLSKDGTSIRPSSIFVHIKITE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	16/88 (18%)
		PLN02222	213..850	CDD:177868	233/647 (36%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	141/384 (37%)
		C2_PLC_like	736..855	CDD:175974	46/129 (36%)
plcd4b	XP_689964.4	PH-like	18..130	CDD:302622	16/86 (19%)
		PH	18..124	CDD:278594	16/80 (20%)
		EF-hand_5	139..163	CDD:289945	8/29 (28%)
		EF-hand_7	143..199	CDD:290234	16/71 (23%)
		EF-hand_10	153..202	CDD:291454	14/58 (24%)
		PLN02228	207..738	CDD:177873	227/635 (36%)
		EF-hand_like	207..289	CDD:286375	28/91 (31%)
		PI-PLCc_delta	289..584	CDD:176535	141/384 (37%)
		C2_PLC_like	616..743	CDD:175974	46/131 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850