DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCG1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_005260495.1	Gene:	PLCG1 / 5335	HGNCID:	9065	Length:	1330	Species:	Homo sapiens

Alignment Length:	1262	Identity:	287/1262 - (22%)
Similarity:	424/1262 - (33%)	Gaps:	527/1262 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LDIATIRDVRTGQYAKRPKD-NKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIA 125
            :||..|:::|.|   |..:| ::.::.....|.   :.....:.:|.:| .:..::...|..|..
Human    73 IDIREIKEIRPG---KTSRDFDRYQEDPAFRPD---QSHCFVILYGMEF-RLKTLSLQATSEDEV 130

  Fly   126 QLWTDGLI--------------------KLAYS-----------------LAQLNGSA--IMFLQ 151
            .:|..||.                    |..||                 |:|:|...  :.||:
Human   131 NMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLR 195

  Fly   152 KAHTKLCLQVDKSGRIPVKNIIKLF------AQNKEDRKRVEKALDVTGLPSG-KVDSISVSKFQ 209
            :..|.|   ..:||.|......:|:      ||...|.    ..|:.:.|.:| :.:...||..:
Human   196 ERLTDL---EQRSGDITYGQFAQLYRSLMYSAQKTMDL----PFLEASTLRAGERPELCRVSLPE 253

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            |:.|  |..|..:...|:||                |:.||:....||| |.||..||
Human   254 FQQF--LLDYQGELWAVDRL----------------QVQEFMLSFLRDP-LREIEEPY------- 292

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLD-LC-DDMDQPMSHYFINSSHNTYL 337
                             ..||.|:.:|...:|.:. .|:|| :| |.|:.|:|||:|:|||||||
Human   293 -----------------FFLDEFVTFLFSKENSVW-NSQLDAVCPDTMNNPLSHYWISSSHNTYL 339

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ||.|.:.:||:|.|.:||..||||:|||.|:|....|||.||:|...:|...|||..|.|.||..
Human   340 TGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVA 404

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD-LPPPAMLRRKIIIKNK 466
            ||||||||.|:||:..||..:|.|.:::.||.||.|     |:|.:.| ||.|..|:|||:||:|
Human   405 SEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTK-----PVEISADGLPSPNQLKRKILIKHK 464

  Fly   467 K------------------------------------KHHHHHHH-------------------- 475
            |                                    .|..:.|:
Human   465 KLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGN 529

  Fly   476 HHHKKPAQV----------------------GTPAANNKLT------------------------ 494
            ...::|.:|                      |...|...||
Human   530 EDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGD 594

  Fly   495 --------------------------------------------------TANSVDAKAAQQVGL 509
                                                              ..|..:.:.::.|..
Human   595 YTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQ 659

  Fly   510 SASHED-----GGVTRSTANGDVATGTGTGS-----------------AAGTAGHAPPLQQ---- 548
            :.:||.     ..:||:.|...:......|:                 |.|...|....|:
Human   660 TNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTV 724

  Fly   549 -------------------------------IRQSSKDSTGSSDSD------------------- 563
                                           |.:.:.:..|:::.|
Human   725 MLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPM 789

  Fly   564 --------------SSSEDE--------------------------------------------- 569
                          :..|||
Human   790 PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVA 854

  Fly   570 ---SLPNTTPNLPSGN------EPP-------PE-------------------------KAQKE- 592
               ...:...|.|.|:      :.|       ||                         .:|:|
Human   855 LEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEEL 919

  Fly   593 ------------------TEA---------GAEISALVNYVQPIHFSSFENAEKKNRCY-EMSSF 629
                              ||.         ..|:|.||.|.:|:.|.. |....:..|| :||||
Human   920 QDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSF 983

  Fly   630 DEKQATTLL-KERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQ 693
            .|.:|...: |.:..:|:.||:.||||:||.|.|.||||:.|...|..|.|||||||||.|..||
Human   984 PETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQ 1048

  Fly   694 LNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN---TF 755
            :|..:|......||:|:|..||  |...|||.:|::.|:....:||.||..:.|......   .|
Human  1049 MNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPF 1111

  Fly   756 VEVDMYGLPADTVRKK-------------------------------------FRTKTVRDNGMN 783
            ||:::.|...|:.::|                                     |......|||:|
Human  1112 VEIEVAGAEYDSTKQKTEFVGQSVFPVILLILLGHCKPLPTSHPILSHGDLKPFVVAFTVDNGLN 1176

  Fly   784 PLYDEEPFVFKKVVLPELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIA 844
            |::..:||.| ::..||.|.:|...|||    ....:.....||.||..|||.|.|::...:.:.
Human  1177 PVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLE 1240

  Fly   845 LASLFLCVVVKDYVP-----DDLSNFA 866
            ||||.:.:   |..|     .|||.|:
Human  1241 LASLLIKI---DIFPAKQENGDLSPFS 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	21/120 (18%)
		PLN02222	213..850	CDD:177868	243/1041 (23%)
		EF-hand_like	225..317	CDD:286375	22/92 (24%)
		PI-PLCc_beta	317..702	CDD:176533	166/744 (22%)
		C2_PLC_like	736..855	CDD:175974	40/162 (25%)
PLCG1	XP_005260495.1	PH_PLC_gamma	29..151	CDD:270168	15/84 (18%)
		PH	<71..142	CDD:278594	15/75 (20%)
		PI-PLCc_gamma	319..>466	CDD:176534	79/151 (52%)
		PH-like	489..>523	CDD:302622	2/33 (6%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	5/103 (5%)
		SH2_C-SH2_PLC_gamma_like	663..765	CDD:198186	11/101 (11%)
		SH3_PLCgamma1	791..850	CDD:212903	3/58 (5%)
		PHsplit_PLC_gamma	<864..933	CDD:270054	8/68 (12%)
		PLCYc	954..1069	CDD:128454	52/115 (45%)
		C2_PLC_like	1087..1250	CDD:175974	40/166 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750