DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and PLCL1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_006217.3 Gene:PLCL1 / 5334 HGNCID:9063 Length:1095 Species:Homo sapiens


Alignment Length:1136 Identity:299/1136 - (26%)
Similarity:478/1136 - (42%) Gaps:282/1136 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 TMRVDAKGFFLYWVDQNNELD--ILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVT 102
            |:..|.:.  |.|.....:|:  .|||:.|:::|.|:..:..::|.|...:       .|:...:
Human   136 TLDTDLQA--LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCAFS 191

  Fly   103 VCHGSDFVNMTFVNFCCTRRDIAQLWTDGL-------------------------IKLAYSLAQL 142
            :.||.::.::..|   ....|:|.:|..||                         :|..:..|.:
Human   192 ILHGENYESLDLV---ANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADV 253

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            :|:.|| |:....:|..|::     |.....|:..:.||.:|..||.               .::
Human   254 DGNGIM-LEDTSVELIKQLN-----PTLKEAKIRLKFKEIQKSKEKL---------------TTR 297

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPAR 272
            ...|:|...:..|..|.||..|...|..|  ::.:....|:.||...|....:.|.:        
Human   298 VTEEEFCEAFCELCTRPEVYFLLVQISKN--KEYLDANDLMLFLEAEQGVTHITEDI-------- 352

  Fly   273 AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYL 337
            ..::|::||.::...|||.|::|||.:||:..:..|..|.:..:..||.||:|||:||:||||||
Human   353 CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 417

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ...|..|.:.:..|.:.|..|||.||||..:|...||::.:.......:..:.|:|.|.:.||..
Human   418 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVA 482

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK 467
            ||||:||...|||:..||..:|...:::||:.|..:.    ||.....||.|..|:|.||:|.||
Human   483 SEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIVKGKK 543

  Fly   468 KHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTG 532
                              .|:..:.|                     :|.||......:::    
Human   544 ------------------LPSDPDVL---------------------EGEVTDEDEEAEMS---- 565

  Fly   533 TGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGA 597
                             |:.|.|..|.                              ||:.....
Human   566 -----------------RRMSVDYNGE------------------------------QKQIRLCR 583

  Fly   598 EISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTR 662
            |:|.||:..:.:.:..||.:.|....:||.||.|.:|:.:..|.|.:||||||..|||:||:..|
Human   584 ELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMR 648

  Fly   663 FDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAES 727
            .||||..||.|||.|||:||:||||....|.|:.|.|..|...||:|:|..||   ..:..|:.:
Human   649 IDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMR---DEVSYFSAN 710

  Fly   728 TVDGIIAG----TVSITVLSGQ-FLTDKRA-------NTFVEVDMYGLPADTVRKKFRTKTVRDN 780
            | .||:.|    .:.|.::||| |...|.|       :.:|.::::|:|||...:  |||||:.|
Human   711 T-KGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQN 772

  Fly   781 GMNPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQP 842
            ..||::| |.|.| :|.|||||.||....::   |.:.||...:|...|.||||||.|||.||..
Human   773 SDNPIFD-ETFEF-QVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDI 835

  Fly   843 IALASLFLCVVVKDYVPDDLSNFAEALANPI------KYQSELEKRDIQLSVLTD--------EA 893
            :...:||:.:.:     .:.|...:|....:      |.:.....|:|.|..:.|        ..
Human   836 MEHVTLFVHIAI-----TNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLR 895

  Fly   894 EALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDS 958
            ||: ...|::..:.|.:      |||..:..:|:..:...::|:..     :|.|.|      .|
Human   896 EAI-DMRENMQNAIVSI------KELCGLPPIASLKQCLLTLSSRL-----ITSDNT------PS 942

  Fly   959 ISIV-------------APSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPL-EKILDHKSVKE 1009
            :|:|             .|.:|     .:.::.....::.|:|.::  :|:.: |||:   ..::
Human   943 VSLVMKDSFPYLEPLGAIPDVQ-----KKMLTAYDLMIQESRFLIE--MADTVQEKIV---QCQK 997

  Fly  1010 KRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFA--IT-------------NKLVKRLSN 1059
            ..:|..::|.:|..|.        |.|...|......||  ||             |:.::.:..
Human   998 AGMEFHEELHNLGAKE--------GLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQ 1054

  Fly  1060 KSLNCLSPHSEPGVEIPACPLDLGDSSEESA 1090
            ..|.|||           |.|....||...|
Human  1055 IQLACLS-----------CGLSKAPSSSAEA 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 24/131 (18%)
EFh_PI-PLC21 151..305 CDD:320043 35/153 (23%)
EF-hand motif 151..180 CDD:320043 4/28 (14%)
EF-hand motif 187..216 CDD:320043 4/28 (14%)
EF-hand motif 225..255 CDD:320043 8/29 (28%)
EF-hand motif 272..305 CDD:320043 12/32 (38%)
PI-PLCc_beta 317..702 CDD:176533 121/384 (32%)
C2_PLC_like 736..855 CDD:175974 50/129 (39%)
PTZ00121 <981..>1253 CDD:173412 27/126 (21%)
PLCL1NP_006217.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61
Interaction with PPP1C 83..222 22/97 (23%)
PH_PLC_eta 115..223 CDD:270170 22/98 (22%)
EFh_PRIP1 243..385 CDD:320052 41/172 (24%)
EF-hand motif 243..272 CDD:320052 8/29 (28%)
EF-hand motif 279..311 CDD:320052 8/46 (17%)
EF-hand motif 315..343 CDD:320052 8/29 (28%)
EF-hand motif 352..385 CDD:320052 12/40 (30%)
PI-PLCc_PRIP_metazoa 398..688 CDD:176539 121/383 (32%)
Interaction with GABA A beta subunit. /evidence=ECO:0000250 543..567 6/83 (7%)
C2_PLC_like 720..848 CDD:175974 50/136 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1066..1095 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

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