DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCD1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001124436.1	Gene:	PLCD1 / 5333	HGNCID:	9060	Length:	777	Species:	Homo sapiens

Alignment Length:	881	Identity:	268/881 - (30%)
Similarity:	392/881 - (44%)	Gaps:	211/881 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EKFIRWDDDSGTGTPVTMRVDAKGFFLYW-----VDQNNELDILDIATIRDVRTG-------QYA 76
            |:|.:..:|..|               .|     |.:..|..:..|..|::||.|       ::|
Human    60 ERFYKLQEDCKT---------------IWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFA 109

  Fly    77 KRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            :...:::...||....::||           |.:..:..:        ||.|..||.|:.:....
Human   110 RDVPEDRCFSIVFKDQRNTL-----------DLIAPSPAD--------AQHWVLGLHKIIHHSGS 155

  Fly   142 L----------------------NGSAIMFLQKAHTKLCLQVDKS-GRIPVKNIIKLFAQNKEDR 183
            :                      |..:...||....:|.:|||.| .|       |:|.:
Human   156 MDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYAR-------KIFRE----- 208

  Fly   184 KRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLV 248
                            .|.......:.|:....||.||||.|::|.|....|:.  :.:|:.|||
Human   209 ----------------CDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSG--ETLSVDQLV 255

  Fly   249 EFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSK 313
            .||...||:..        |.||.|..||::|||::....:.|::.||||.||:..|....:.:.
Human   256 TFLQHQQREEA--------AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAH 312

  Fly   314 LDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVH 378
            ..:..||.||:|||.::|||||||...||.|.||.|.|.:.|..||||:|||.|:|..:||:|.|
Human   313 RRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYH 377

  Fly   379 GYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSH 443
            ||||..:|...|||.||.:.|||.|.||||||.||||...||..:|.:...|.|.|||::|||.
Human   378 GYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDG- 441

  Fly   444 PLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVG 508
               ....||.|..|:.||::|.||                :|                      |
Human   442 ---VTNSLPSPEQLKGKILLKGKK----------------LG----------------------G 465

  Fly   509 LSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSS--EDESL 571
            |.....:||                                    .::|..||.|.::  |||::
Human   466 LLPPGGEGG------------------------------------PEATVVSDEDEAAEMEDEAV 494

  Fly   572 PNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRC-YEMSSFDEKQAT 635
            .:...:.|.         :.:.....|:|.:|.|.:.:||..|.:.....:. |||:||.|.:|.
Human   495 RSRVQHKPK---------EDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRAL 550

  Fly   636 TLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFE 700
            .||:|....||.:|...|||:||||.|.||||:.|...||.|||:|||||||....|.:..|.|:
Human   551 RLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQ 615

  Fly   701 YNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVE----VD 759
            .|...||:|||.|:|..:...:|.|.:.........::|.|:|||.|  .:|..|:.|:    |:
Human   616 DNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVE 680

  Fly   760 MYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIR--IAAYEEGGK--LIGHRV 820
            ::|:..|...:  :|..:.:||.||.:|.| |.| :||:|:||.||  :..|:...|  .||...
Human   681 IHGVSRDVASR--QTAVITNNGFNPWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQST 741

  Fly   821 LPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            :|:..|..|||||:|.|:.|.....|:||:.:.::|
Human   742 IPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	25/154 (16%)
		PLN02222	213..850	CDD:177868	229/649 (35%)
		EF-hand_like	225..317	CDD:286375	29/91 (32%)
		PI-PLCc_beta	317..702	CDD:176533	140/387 (36%)
		C2_PLC_like	736..855	CDD:175974	45/128 (35%)
PLCD1	NP_001124436.1	PH_PLC_delta	43..160	CDD:270169	24/133 (18%)
		PH	51..151	CDD:278594	24/124 (19%)
		EF-hand_10	180..229	CDD:291454	14/76 (18%)
		PLN02228	233..776	CDD:177873	224/643 (35%)
		EF-hand_like	234..316	CDD:286375	29/91 (32%)
		PI-PLCc_delta	316..617	CDD:176535	140/387 (36%)
		C2_PLC_like	650..776	CDD:175974	45/129 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3066
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.700