DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCB4

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001364071.1	Gene:	PLCB4 / 5332	HGNCID:	9059	Length:	1206	Species:	Homo sapiens

Alignment Length:	1310	Identity:	490/1310 - (37%)
Similarity:	700/1310 - (53%)	Gaps:	220/1310 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EVPQALQDGEKFIRWDDDSGTGTP-VTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKR 78
            |||..||:|..|.|::::|....| ...:||..||||.|..:..|..:|:.:.|..:|:|...|.
Human    12 EVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKD 76

  Fly    79 PKDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQL 142
            ||  .|..:..:| .::.||.:.|.||.|:|.||::|........::.:.|.:||..:.::....
Human    77 PK--ILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRAN 139

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            |.|.:..|:|...||....:.:|:|||::|.:.||..|.: |.:.:||...||||||.|.|..:.
Human   140 NVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTE-KVIFQALKELGLPSGKNDEIEPTA 203

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPAR 272
            |.:|.||.|.:.:..|:::|.||..|.|: |...:::.|||.|||:.||||||||||:|:.:..|
Human   204 FSYEKFYELTQKICPRTDIEDLFKKINGD-KTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKR 267

  Fly   273 AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYL 337
            |.::|:.|||::...:||.:|.|||.||||.|:|..:...:|:|..:||.|::||||:|||||||
Human   268 AMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYL 332

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--EPVIVHGYTFVPEIFAKDVLEAIAESAF 400
            ||.|..||||||:|||.|||||||||||.|:|:.|  ||:|.||.....:|..|||::||.|:||
Human   333 TGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAF 397

  Fly   401 KTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKN 465
            .||||||||||||||:..||.|::.||.::|||:||.:.|:||||||...||.|..|:|||:|||
Human   398 VTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKN 462

  Fly   466 KKKHHHHHHHHHHKKP----------------AQVGTPAANNKLTTANSVDAKAAQQ-------- 506
            |:           .||                .:..:||  |.|...|..:.::|.|
Human   463 KR-----------LKPEVEKKQLEALRSMMEAGESASPA--NILEDDNEEEIESADQEEEAHPEF 514

  Fly   507 -VGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDS--SSED 568
             .|...|.:|.|...:.||                       .::::|.|....::...  :.||
Human   515 KFGNELSADDLGHKEAVAN-----------------------SVKKASDDLEHENNKKGLVTVED 556

  Fly   569 E-----------SLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNR 622
            |           :..|..|.|                     |.::||.||:.|..|..||::|.
Human   557 EQAWMASYKYVGATTNIHPYL---------------------STMINYAQPVKFQGFHVAEERNI 600

  Fly   623 CYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQT 687
            .|.||||:|......||...||||||||.|:||:||.|.|.||||:|||:|||||||:|:||:||
Human   601 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQT 665

  Fly   688 LDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRA 752
            .|||||||.|.||||...||||||:||||.||..|||:|:.|||:||.|.|:.|:|||||:||:.
Human   666 PDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKI 730

  Fly   753 NTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIG 817
            .|:|||||||||.||:||:|||:.|.:||:||:|:||.|||:||:||:||.:|||.|::..||||
Human   731 GTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIG 795

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKR 882
            .|:||:.||..||||::||:|..:|::|.::|..:|:|.||||...:..:||::|.|:.|..|||
Human   796 QRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKR 860

  Fly   883 DIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTV 947
            ..|:..:..|...:.....|.||:....:....|..:.|    .:|.:.||:.:||.|..|:
Human   861 ADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTP----QSSSELRPTTTAALASGVE--- 918

  Fly   948 DRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKE--K 1010
                                                  ::..::|:   |..:|.|.|.:|.  |
Human   919 --------------------------------------AKKGIELI---PQVRIEDLKQMKAYLK 942

  Fly  1011 RL-EMEKKLESLRKKHDKE-----KI------KIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLN 1063
            .| :.:|:|.||:|||.||     |:      ||..|..   :.|.....|..|.:|:....  |
Human   943 HLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYD---KEKSTHEKILEKAMKKKGGS--N 1002

  Fly  1064 CLSPHSEPGVEIPACPLDLGDSSEESAAADAGE--DLAGGSSSLDGRTQESRLRSACREYTSQYR 1126
            ||....|..::|.....|.....:|..|....|  ::....|:     :|..:|..   :.||..
Human  1003 CLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSA-----EEQEIRDL---HLSQQC 1059

  Fly  1127 ELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEV-MHQLQEARRN--------EVKNLA 1182
            ||           .:|:|..:...||:|||.|.|:.:.|: .||.:.:..|        .:||.|
Human  1060 EL-----------LKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKA 1113

  Fly  1183 TVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILD 1247
                   |..|..||:.||..::.:.||.||.....:..|:|:|       ...||    .:.|:
Human  1114 -------ERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKK-------VQLEH----LEFLE 1160

  Fly  1248 KEAES--RSC 1255
            |:.|.  :||
Human  1161 KQNEQLLKSC 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	38/126 (30%)
		PLN02222	213..850	CDD:177868	317/676 (47%)
		EF-hand_like	225..317	CDD:286375	42/91 (46%)
		PI-PLCc_beta	317..702	CDD:176533	181/424 (43%)
		C2_PLC_like	736..855	CDD:175974	68/118 (58%)
PLCB4	NP_001364071.1	PH_PLC_beta	17..143	CDD:270167	38/127 (30%)
		EFh_PI-PLCbeta4	148..300	CDD:320041	67/153 (44%)
		PI-PLCc_beta	312..680	CDD:176533	181/424 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..511		7/30 (23%)
		C2_PLC_like	714..830	CDD:175974	67/115 (58%)
		PTZ00121	<859..1206	CDD:173412	93/402 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..907		6/35 (17%)
		DUF1154	926..967	CDD:399553	16/43 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1122		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720