DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCE1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_006717948.1	Gene:	PLCE1 / 51196	HGNCID:	17175	Length:	2316	Species:	Homo sapiens

Alignment Length:	1236	Identity:	303/1236 - (24%)
Similarity:	496/1236 - (40%)	Gaps:	321/1236 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 NMTFVNF--------CCTRRDIAQLWTDGLIKLAYSL-AQLNGSAIMFLQKAHTKLCLQVDKSGR 166
            ||:||.|        ..:|:|:..|:.      .|:: ...:||....|   :|.|.:..:.|..
Human  1212 NMSFVEFVELFKSFSVRSRKDLKDLFD------VYAVPCNRSGSESAPL---YTNLTIDENTSDL 1267

  Fly   167 IP-----VKNI--IKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRS 224
            .|     .:|:  :.||.::|:                    .:|.::.|..|.......:|..:
Human  1268 QPDLDLLTRNVSDLGLFIKSKQ--------------------QLSDNQRQISDAIAAASIVTNGT 1312

  Fly   225 EVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP-RLNEILYPYANPARAKELIQQYEPNKFNAQ 288
            .:|.....|.|      :.|.||.:||...|.:. ..:|||          .:||::||:.....
Human  1313 GIESTSLGIFG------VGILQLNDFLVNCQGEHCTYDEIL----------SIIQKFEPSISMCH 1361

  Fly   289 KGQLSLDGFLRYLMGDDNPIMAPSKLDLCD----DMDQPMSHYFINSSHNTYLTGHQLTGKSSVE 349
            :|.:|.:||.|:||..:|   ..||.|...    ::..|:|:|:|.||||||||||||.|:||||
Human  1362 QGLMSFEGFARFLMDKEN---FASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVE 1423

  Fly   350 IYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENH 414
            :|.|.||.|||.||||.|:|....|:|.||:|...:|..|:|:|||..|||..|:.|:|:|.|||
Human  1424 LYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENH 1488

  Fly   415 CNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHK 479
            |:..||.|:|...:.:||:.|:.|.|.......:..||.|..||:|:::||||...|.
Human  1489 CSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQ------- 1546

  Fly   480 KPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVT---------------------RSTA 523
                          |..:.:..||.|...:.....:||..                     .|.:
Human  1547 --------------TPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLS 1597

  Fly   524 NGDVATGTGTGSAAGTAGHAPPLQQ--IRQSSKDSTGSSDSDSSSEDESLP-------NTTPN-- 577
            :.||.          ||..||..|:  |.:...::...:|......:|.:|       |:..|
Human  1598 DADVL----------TASPAPNGQEDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKG 1652

  Fly   578 ----LPSGNEPPPEKAQKET-EAGAEISALVNYVQPIHF---------SSFENAEKKNR------ 622
                :..|.|...::.:||: :...|:|.||.|.|.:.|         .|....|:|:|
Human  1653 KVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGN 1717

  Fly   623 --------------------------------------------------CYEMSSFDEKQATTL 637
                                                              ||.:||.:|..|..|
Human  1718 NPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRL 1782

  Fly   638 LKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYN 702
            .:....:...:...||.|.|||.||.||||..|.:||..|.||||||:||.||.:.||..:||.|
Human  1783 CRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEAN 1847

  Fly   703 ARSGYLLKPEFMRRSD----RRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVEVDMY 761
            ...||:|||..:...:    ::..|. |..:|.:.....|:|::|||.:  ::...:..:|||:.
Human  1848 GGCGYVLKPPVLWDKNCPMYQKFSPL-ERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVL 1911

  Fly   762 GLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLI-GHRVLPVIG 825
            |:|.|:..  ||||.:..|.:||:::|: |:| .|...:|..:|.|..|.....: ..|::|:..
Human  1912 GMPLDSCH--FRTKPIHRNTLNPMWNEQ-FLF-HVHFEDLVFLRFAVVENNSSAVTAQRIIPLKA 1972

  Fly   826 LCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVL- 889
            |..||||:.||:...:.:.::|||:                    |..:.:.......:..|.:
Human  1973 LKRGYRHLQLRNLHNEVLEISSLFI--------------------NSRRMEENSSGNTMSASSMF 2017

  Fly   890 -TDEAEALGSADEDL-----SKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVD 948
             |:|.:.|.:....:     .:.|....:.|..|..:.::.:.|:.:             |:...
Human  2018 NTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQ-------------DIKPV 2069

  Fly   949 RTDGGRGEDSISIVAPSIQ-HQHSLDQSV--STSIRQVESSQFDVDLVLAEPLEKILDHKSVKEK 1010
            .||....|:...|.....: .:....:::  ...|.|:.||.|        |.|..:.
Human  2070 TTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWF--------PEEGYMG------- 2119

  Fly  1011 RLEMEKKLESLRKKH----DKEKIKIAGQKS--------SPLEG----KKPKFAITNKLVKRLSN 1059
            |:.::.:.|:|.:|:    |||.|..:.::|        ||.:.    |.|:.:....::::...
Human  2120 RIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLC 2184

  Fly  1060 KSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSAC------ 1118
            |:....|..|.|            :.|:.....:..:|.....::....:|...|...|
Human  2185 KAKYSYSILSNP------------NPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQS 2237

  Fly  1119 ------------REYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQ 1171
                        :|.....||.::|   .|..|:|....|..|.|.:.|.:....:|.|.:...:
Human  2238 KWKGAGKFILKLKEQVQASREDKKK---GISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKE 2299

  Fly  1172 E 1172
            |
Human  2300 E 2300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	9/42 (21%)
		PLN02222	213..850	CDD:177868	222/750 (30%)
		EF-hand_like	225..317	CDD:286375	27/92 (29%)
		PI-PLCc_beta	317..702	CDD:176533	148/490 (30%)
		C2_PLC_like	736..855	CDD:175974	38/121 (31%)
PLCE1	XP_006717948.1	RasGEF	539..713	CDD:279011
		PLN02952	1318..1997	CDD:178538	220/733 (30%)
		EF-hand_like	<1328..1379	CDD:286375	19/60 (32%)
		PI-PLCc_epsilon	1391..1847	CDD:176538	148/486 (30%)
		C2_PLC_like	1886..1998	CDD:175974	38/135 (28%)
		UBQ	2151..2250	CDD:294102	13/110 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840