DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plc21C and plcd1b

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_005163413.1	Gene:	plcd1b / 337489	ZFINID:	ZDB-GENE-030131-9435	Length:	772	Species:	Danio rerio

Alignment Length:	866	Identity:	273/866 - (31%)
Similarity:	397/866 - (45%)	Gaps:	164/866 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QALQDGEKFIRWDDDSGTGTP-VTMRVDAKGFFLYWVDQNNEL---DILDIATIRDVRTGQYAKR 78
            |.|.:|...::...:|...|. ..::.|.|   ..|.:....|   ....|..|.:||||:
Zfish    42 QFLMNGGDLLKVRSESWKKTRYFKLQEDCK---TMWHESKKTLKTKQTFSIEDIEEVRTGR---- 99

  Fly    79 PKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
             :.:.||:..    ::|||.:..::....   ....::...:..:.|:.|..||.|:..||..|:
Zfish   100 -QTDSLRKYT----EETLEGRAFSILFKG---RQKSLDLIASTEEEAKKWVSGLEKVISSLNNLS 156

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKAL---------DVTGLPSGK 199
            .      ||   |....:..|.|...||:     .||...|.|:..|         |...:...:
Zfish   157 S------QK---KTEHWIYSSLRKADKNL-----DNKMSLKEVKSFLKDINVEVHEDYAEMLFKE 207

  Fly   200 VDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRK--CMSIAQLVEFLNKTQRDPRLNE 262
            .|..:....:..:..:.||.||:|.|:    |.|.|...:.  .||...|:.||...||:.
Zfish   208 CDKSNGGFLEGNEIEHFYKILTKREEI----DVIYGEYAKTDGLMSANDLLNFLLTEQREE---- 264

  Fly   263 ILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHY 327
                 .:...|.:||::||.::....|.|::.||||.||...:..|...:...:..||:||:|||
Zfish   265 -----VSQNDALQLIEKYELDENAKAKQQMTQDGFLMYLHQPEGLIFNQAHKSVYHDMNQPLSHY 324

  Fly   328 FINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVL 392
            ||:|||||||...||.|.||.|.|.:.||.||||||||.|:|...||||.||||...:|..|||:
Zfish   325 FISSSHNTYLMEDQLKGPSSTEAYIRALLKGCRCVELDCWDGSDGEPVIYHGYTLTSKILFKDVI 389

  Fly   393 EAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPL-DSHPLEPNMDLPPPAM 456
            :||.|.||||||||||||.||||...||..:|.:...|.|..|:.||| |..|    ..||.|..
Zfish   390 KAIKEYAFKTSEYPVILSLENHCGVEQQKIMAQHLTSILGSALVTKPLGDQMP----TCLPAPEE 450

  Fly   457 LRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRS 521
            |:.:.|:|.|:
Zfish   451 LKGRFIVKGKR------------------------------------------------------ 461

  Fly   522 TANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPP 586
                                    |.::..:..|.:..:|.:|.||:|.        ..|:|...
Zfish   462 ------------------------LDKLENAFSDESKMADEESVSEEED--------DEGDEENN 494

  Fly   587 EKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKH 651
            ||.....:...|:|.:|.|.:.:.|...|::.:|:..|||:||.|.:|..|.:|...|::.:|..
Zfish   495 EKKSGSLKLAKELSDIVIYCKSVPFHGLEDSREKHSFYEMASFKEGKALKLAEESATEYIRHNTD 559

  Fly   652 QLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRR 716
            :|||:||.|.|.||||:.|...||||||:|||||||..|.|.||.|:|..|.||||:|||.::|.
Zfish   560 KLSRIYPGGMRTDSSNYNPVPMWNAGCQIVALNFQTPCLEMDLNQGLFYQNGRSGYILKPSYLRE 624

  Fly   717 SDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVE----VDMYGLPADTVRKKFRTK 775
            .|...||...:....:...|:.:.|:|.|.|  ..||.:..|:    |.:||:||||.  ...|.
Zfish   625 RDTEFDPITLTKGPWLKRKTLHVMVISAQQLPKVGKRESAIVDPIVKVQVYGVPADTA--AVETS 687

  Fly   776 TVRDNGMNPLYDEEPFVFK-KVVLPELASIR--IAAYE--EGGKLIGHRVLPVIGLCPGYRHVNL 835
            .:::||.||:::|.   |: :|.:|:||.:|  |..|:  ...:.||...||...|..||.||.|
Zfish   688 YIKNNGFNPMWNEN---FQLEVCVPDLALVRFLIEDYDSTSDNEFIGQYTLPFNSLRNGYHHVPL 749

  Fly   836 RSEVGQPIALASLFLCVVVKD 856
            .::.|..::.|.||:.::|.|
Zfish   750 LTQDGNLLSSAGLFVHIMVVD 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/128 (21%)
		PLN02222	213..850	CDD:177868	228/650 (35%)
		EF-hand_like	225..317	CDD:286375	25/93 (27%)
		PI-PLCc_beta	317..702	CDD:176533	144/385 (37%)
		C2_PLC_like	736..855	CDD:175974	43/129 (33%)
plcd1b	XP_005163413.1	PH_PLC_delta	44..159	CDD:270169	27/135 (20%)
		PH	48..150	CDD:278594	22/116 (19%)
		EF-hand_10	179..228	CDD:291454	8/48 (17%)
		PLN02228	232..764	CDD:177873	223/639 (35%)
		EF-hand_like	233..314	CDD:286375	25/93 (27%)
		PI-PLCc_delta1	314..610	CDD:176566	144/385 (37%)
		C2_PLC_like	643..768	CDD:175974	43/129 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750