DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and sl

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster

Alignment Length:	1249	Identity:	274/1249 - (21%)
Similarity:	415/1249 - (33%)	Gaps:	506/1249 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEK 99
            |.||   |.|.:|             .:.:..||::|.|:::|.      .::.....|.....|
  Fly    59 TQTP---RTDYEG-------------AIQLREIREIRVGKHSKE------FRLFADDCQRFESSK 101

  Fly   100 TVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKS 164
            ...:.||:.|...:|.....:..: |..|..|   |.|.:....|:...          ||:|:.
  Fly   102 CFVILHGNHFKLKSFSVVALSEIE-ADNWVRG---LRYMVKDTLGAPYP----------LQIDRW 152

  Fly   165 GR---IPVKNIIKLFAQNKEDRKRVEKA------LDVTGLPSGKVDSISVSKF------------ 208
            .|   ..::|:      |....|..|::      .|.....:|....::..||
  Fly   153 LRREYYQIENV------NTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKH 211

  Fly   209 --QFEDFYNLY-KYLTQRSEVERLFDSIVGN----SKRKCMSIAQLVEFLNKTQRDPRLNEILYP 266
              :|:||..|| |.|........|..|.|.|    ..::.:..|:|.:||...|||...:||
  Fly   212 DLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEI--- 273

  Fly   267 YANPARA---KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLD-LCDDMDQPMSHY 327
             ::.|.|   ::.:|..|.   :.|:..|:...|:.:|....|.:. .||.| :..||:.|:|.|
  Fly   274 -SSAAIASFIRDFVQDVER---DVQEPYLTFPEFVDFLFSKQNDLW-NSKYDQVFMDMNLPLSSY 333

  Fly   328 FINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVL 392
            :|.|||||||||.|.:.:||.|.|.:.|..||||:|||.|||....|.|.||:|...:|...||:
  Fly   334 WIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVI 398

  Fly   393 EAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAML 457
            :.|.:.||.:||||||||.|.:|:..||..:|....|:||||||.:|.|.:    ...||.|..|
  Fly   399 KTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN----EQHLPSPYQL 459

  Fly   458 RRKIIIKNKK-----------------KH-----------HHHHHHHHHKKPAQVGT-------- 486
            |||||:|:||                 .|           |..:...:.:|..:.|.
  Fly   460 RRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVD 524

  Fly   487 -----------------PAANNKLTTANSVDAKAAQQVGLSAS---------------------- 512
                             .:..|:....||.|    ...|||:|
  Fly   525 KSWNLYQFVLTHQELIYSSEINESRNGNSED----DDFGLSSSCSLNSNMQQKQKDTSANDELHF 585

  Fly   513 -------------------------------------------------------------HEDG 516
                                                                         ||:|
  Fly   586 GENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENG 650

  Fly   517 GV--------------------------------------------------------------- 518
            .:
  Fly   651 SIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGL 715

  Fly   519 -----------------------------------------------------------TRS--- 521
                                                                       ||:
  Fly   716 YRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLY 780

  Fly   522 --------------------TANGDVATGTGTGSAAGTAG------------------------- 541
                                .|.||.:.|.....|:...|
  Fly   781 RNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSF 845

  Fly   542 ---------------------------HAPP--LQQIRQSSKD--STGSSDSDSSSEDESLPNTT 575
                                       |.|.  ::.|..:::|  |.....:|..::...:....
  Fly   846 PKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAV 910

  Fly   576 PNLPSGNEP--------------------------------------------PPEKAQKETEA- 595
            .:|...|:|                                            ..|:.:||..|
  Fly   911 ASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTAR 975

  Fly   596 -GAEISALVNYVQPIHFSS----FENAEKKNRCYEMSSFDEKQATTLLKERPIE-FVNYNKHQLS 654
             ..|:|.|:.|.:.:.|..    |:         |||||.|.:|.....::..: |::|:::|:|
  Fly   976 VAKEMSDLIIYFRSVPFREHSWIFQ---------EMSSFPETKAEKQFFQQNTQLFLSYHRNQIS 1031

  Fly   655 RVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDR 719
            ||||.|.|.|||||.|..|||.|.|::|||:||.|.|||||...|..|.:.||:|||.||:.
  Fly  1032 RVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKS--- 1093

  Fly   720 RLDPFAEST--VDGIIAGTVSITVLSGQ--FLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDN 780
              |.|..:.  .||:....|||.:::.:  |...|..|..:.|::.|...|| ..|:||| |.:|
  Fly  1094 --DSFNPNNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDT-GVKYRTK-VNEN 1154

  Fly   781 GMNPLYDEE-PFVFKKVVLPELASIRIAAYEEG----GKLIGHRVLPVIGLCPGYRHVNLRSEVG 840
            |.||:::|. .|   .|..|:.|.:|....:|.    ...|.....|:..:..|||.|.||::..
  Fly  1155 GFNPVWNESCEF---NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFS 1216

  Fly   841 QPIALASLFLCVVV 854
            :.:.|:||.:.:.:
  Fly  1217 EELELSSLLINIKI 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	22/109 (20%)
		PLN02222	213..850	CDD:177868	237/1042 (23%)
		EF-hand_like	225..317	CDD:286375	25/99 (25%)
		PI-PLCc_beta	317..702	CDD:176533	158/772 (20%)
		C2_PLC_like	736..855	CDD:175974	37/126 (29%)
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	23/123 (19%)
		PI-PLCc_gamma	323..>470	CDD:176534	75/150 (50%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	2/99 (2%)
		SH3_PLCgamma	828..880	CDD:212759	2/51 (4%)
		PLCYc	981..1091	CDD:128454	51/118 (43%)
		C2_PLC_like	1109..1215	CDD:175974	34/110 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456393
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2757
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850