DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plch2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_008762618.2	Gene:	Plch2 / 313756	RGDID:	1304675	Length:	1570	Species:	Rattus norvegicus

Alignment Length:	1435	Identity:	345/1435 - (24%)
Similarity:	552/1435 - (38%)	Gaps:	434/1435 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVR 71
            |:|:|.:.::            :|..:||.. .|::|::           ||...:.|.:|::|.
  Rat   191 AMQEGTQMVK------------LRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVS 243

  Fly    72 TGQYAKRPKDNKLRQIVTLGPQDTLEEK-TVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL--- 132
            .|:.:         :|....|..:.:.. ..::.:||...::..|:   ...:.|:.|..||
  Rat   244 EGRQS---------EIFQRYPDSSFDPNCCFSIYYGSHRESLDLVS---PSSEEARTWVTGLRYL 296

  Fly   133 ---IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKS--GRIPVKNIIKLFAQNKEDRKRVEKALDV 192
               |....|||:...:...:|::...    :.||:  |.:.:..:::|..:           |:|
  Rat   297 MAGISDEDSLARRQRTRDQWLKQTFD----EADKNGDGSLSISEVLQLLHK-----------LNV 346

  Fly   193 TGLPSGKVDSI--------SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVE 249
             .||..:|..:        ......||:|...||.::.|.::..|.  :..::.:..:..:.|..
  Rat   347 -NLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM--LTYSNHKDHLDASDLQR 408

  Fly   250 FLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKL 314
            ||...|   :::.:..     ...:.:|:|:||...|..||.|.:|||..|.......|..|...
  Rat   409 FLEVEQ---KMSGVTL-----ESCQSIIEQFEPCLENKSKGVLGIDGFTNYTRSPAGDIFNPEHH 465

  Fly   315 DLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHG 379
            .:..||.||:|||||.|||||||.|.||..:|.|::|...|.|||||||:|.|:|...||::.||
  Rat   466 RVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHG 530

  Fly   380 YTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHP 444
            ||...:|..|||:|.|.:.||..:|||||||.||||:..||.|:|.|..:|.||.|   .|.|..
  Rat   531 YTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKL---DLSSVS 592

  Fly   445 LEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGL 509
            .|....||.|.||:.||::|.|            |.||.:...|...:::..:|.|
  Rat   593 GEDATMLPSPQMLKGKILVKGK------------KLPANISEDAEEGEVSDEDSAD--------- 636

  Fly   510 SASHEDGGVTRSTANGDVATG-------------------------------TGTGSAAGTAGHA 543
              ..||   .....|||.:|.                               ..|.|.:|..||.
  Rat   637 --EIED---DCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFTVSTLSPSGKLGHK 696

  Fly   544 PPLQQIRQSSKDSTGSSDSDSSSE-----------------------------DESLPNTTPNLP 579
            ...::.:..:::...|.:....|.                             ||||  .:|...
  Rat   697 AEAKKAQSKAEEDVESGEDTGVSRRNSRLLMSSFSKRKKKGSKIKKVASVEEGDESL--DSPGSQ 759

  Fly   580 SGNEPPPEKAQKETEAGAEISALVNYVQPI--HFSSFENAEKKNRCYEMSSFDEKQATTLLKERP 642
            |......:|..|.:.|   :|.||.|.:.:  |....|....    :::|||.|.:|..:|:::|
  Rat   760 SRGTARQKKTMKLSRA---LSDLVKYTKSVGTHDVEMEVVSS----WQVSSFSETKAHQILQQKP 817

  Fly   643 IEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGY 707
            .:::.:|:|||||:||:..|.||||:.||.|||||||:||||:|:....:|||...|..|...||
  Rat   818 AQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGY 882

  Fly   708 LLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR----------ANTFVEVDMYG 762
            :|||:.|.:.  ..:|.:|..:.|.:...:::.::|||.|...|          .:.||||::.|
  Rat   883 VLKPQCMCQG--VFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIG 945

  Fly   763 LPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVI 824
            ||.|.  .|.:|:.|.|||.||:: ||..|| .|.:||:|.:|...::.   |...||.|.|...
  Rat   946 LPVDC--SKEQTRVVDDNGFNPMW-EETLVF-TVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFS 1006

  Fly   825 GLCPGYRHV-----------------NLRSEVGQPIALASLFLCVVVKDYVPDDLSNFA------ 866
            .:.||||||                 ::..:|.|.:.|..|||    :...|..|.:.|
  Rat  1007 SMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFL----RGPKPGSLDSHAAGQPLP 1067

  Fly   867 ----------EALANPIKYQSELEKRDIQLSVLTDEAEALGSADE-------------------- 901
                      ...:.|.|.|....|...:|::.|.:|.:.|:||:
  Rat  1068 RPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPPSPNPALEAPTQERSGS 1132

  Fly   902 ----------------------------------------------------------------- 901

  Rat  1133 SSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAVPTGPSQEGPQCPVGQGAKVTGPQQT 1197

  Fly   902 DLSKSFVF-VQVGGQKKE----LRP---------------------------------------- 921
            .|..|... ::.||.:::    |||
  Rat  1198 SLGASGTLQLRTGGDREKEEPPLRPHNGGIPHGPREGTSGRQTDSKSRSWAPGHLPVVRRAKSEG 1262

  Fly   922 --VESLATSP-------------------KHRPSISAAAAMS-----VDVTVDRTDGGRGEDSI- 959
              :..|:.:|                   .||.|:|::::||     :|:::......|..:||
  Rat  1263 QVLSELSPTPAVYSDATGSDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIP 1327

  Fly   960 SIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKK 1024
            .:....:..:..|..:....:..|..|:.:.:|.:|..|....|....:    .:..:|..|..:
  Rat  1328 GVSLGRLTPRPCLASAARPDLPPVTKSKSNPNLRVAGGLPLAPDELQPR----PLAPRLTGLHSR 1388

  Fly  1025 HDKEKIKIAGQKSSPLEGKK------------PKFAITNKLVKRLSNKSLNC-LSP----HS--E 1070
            .....:.:.|.:..|:..|.            |.|        :.|..||:| |||    |.  |
  Rat  1389 PPWHHLTLVGLRDCPVSAKSKSLGDLTADDFGPSF--------QGSTGSLSCGLSPLGVVHQVLE 1445

  Fly  1071 PGVEIPACPLDL---------GDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYR 1126
            ||....|....|         ||.:..::...|.:...||.|.|  |...||.:|..|...|:.|
  Rat  1446 PGRRRDALTEQLRWLTGFQHAGDITSPTSLGPAADGSVGGPSFL--RRSSSRSQSRVRAIASRAR 1508

  Fly  1127 ELQEK 1131
            :.||:
  Rat  1509 QAQER 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	26/143 (18%)
		PLN02222	213..850	CDD:177868	229/728 (31%)
		EF-hand_like	225..317	CDD:286375	19/91 (21%)
		PI-PLCc_beta	317..702	CDD:176533	151/446 (34%)
		C2_PLC_like	736..855	CDD:175974	47/148 (32%)
Plch2	XP_008762618.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850