DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and Plch1

DIOPT Version :9

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_017446352.2 Gene:Plch1 / 310463 RGDID:1561991 Length:1703 Species:Rattus norvegicus


Alignment Length:1518 Identity:356/1518 - (23%)
Similarity:599/1518 - (39%) Gaps:388/1518 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
  Rat    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||                   
  Rat    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:        
  Rat   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|   
  Rat   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            :::.:...|     ..::|:::|.::.|..|..|.::||..::......:..|...::..|||||
  Rat   257 KMSNVTLDY-----CLDVIKKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
  Rat   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            |||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.||.|.|   .|.|........||.
  Rat   382 KDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKL---DLSSVDTGECRQLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD------------------ 500
            |..|:.||::|.||..:|            :|..|...:::..:|.|                  
  Rat   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 496

  Fly   501 --------------AKAAQ------------QVGLSASHEDGGVTRSTANGDVATGTGTGSAAGT 539
                          .|.:|            :..|.|:|| |.......|.||       ..:|.
  Rat   497 HQVESFIRKKLDSLLKESQIRDKEDPDSFTVRALLKATHE-GLNAHLKQNLDV-------KESGK 553

  Fly   540 AGHAPPLQQIRQSSKDSTGSSDSDSSS---EDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISA 601
            ..|...|.......|..|..|.|.|.|   |:::|.|  |....|......:.::..:...|:|.
  Rat   554 KSHGRSLMANFGKHKQKTPKSRSKSYSTDDEEDTLQN--PGKEGGQLYRLGRRRRTMKLCRELSD 616

  Fly   602 LVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSS 666
            ||.|...:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||
  Rat   617 LVVYTNSV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSS 678

  Fly   667 NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG 731
            ||.|..:|||||||||||:|:....||:|...|:.|...||:|||:.|.:.  ..:|.:...:..
  Rat   679 NFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKG--TFNPLSGDPLPA 741

  Fly   732 IIAGTVSITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLY 786
            .....:.:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||::
  Rat   742 NPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW 804

  Fly   787 DEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASL 848
             ||...| .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:
  Rat   805 -EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASI 862

  Fly   849 FLCVVVKDYVPDDLSNFAEALANP----IKYQSELEKRDIQ-LSVLTDEAEALGSADED------ 902
            |:.:.:.:.    ...::..:.||    :.:....:.|.:| |..|.::....||::.:      
  Rat   863 FVHITINEI----FGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHGSSENNSHYVRK 923

  Fly   903 ------LSKSFVFVQVGGQKK---------------------------------ELRPVESLATS 928
                  :.:........|:||                                 :|||| |:...
  Rat   924 RSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVCEATRDQDGVLRRTTRSLQLRPV-SMPVD 987

  Fly   929 PKHRPSIS---AAAAMSVD-----VTVDRTDGGRGEDSI------------SIVAPSIQHQHSLD 973
            .....::|   :.||.:.|     :..|:.||.:|..:|            |..:.::.|:.:.:
  Rat   988 KNLLGALSLPISEAAKNTDGKENYLAEDKDDGRKGPATIKDPHFSNFNKKLSSSSSALLHKDAKN 1052

  Fly   974 QSVSTSIRQVESSQFDVDLVLAEPLEKILDHKS-------------VKEKRLEMEKKLESLRKKH 1025
            |..:.|:...|...     .|.....:|..|.:             ...|.|.::...:.|:..|
  Rat  1053 QGPTASVSNPEQCG-----GLGLKSGRIKPHMTNDCQENRSPQNFLSPRKHLALDPATKGLQDLH 1112

  Fly  1026 -------DKEKIK-IAGQKSSP--------------LEGKKPKFAITNKLVKRLSNKSLNCLSPH 1068
                   ::|:.| ..|:||:.              |||.|.|.......  .||:.|..|   .
  Rat  1113 GMRTDEKEQERAKGFVGRKSTQSESVLSQSSLEVENLEGSKAKGRAATSF--SLSDVSALC---S 1172

  Fly  1069 SEPGVEIPACPLD--LGDSSEESAAADAGEDLAGGS-SSLDGRTQESRLRSACREYTSQYRELQE 1130
            ..|.:...|...|  :.|...:....:|.|  :|.| |:|.|:.:||.                 
  Rat  1173 DIPDLHSTAILQDTEISDLINDVTLTNANE--SGSSISALIGQFEESN----------------- 1218

  Fly  1131 KYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRN---EVKNLATVHRDRDELI 1192
              |.|..:...::|.||.|.:...|..:|.         ||...:|   :.|:.|:......||.
  Rat  1219 --HRANVAVVSRLLSTSGTSEGVALPVALG---------LQTPIKNGFSQGKHKASFLCSSPELN 1272

  Fly  1193 RMK----REVASSVVERGV--------------AERVRLKQTFDRRTDELQKQHDSVRNALAE-- 1237
            :..    .::|::.|..||              :::.:.:.|    .|.|....|:......:  
  Rat  1273 KPSSAETTKLANNTVACGVIGSPISTPKPGDDASDKAKTRVT----EDNLPDSPDAFPGQFPQSP 1333

  Fly  1238 -HRSKARQIL------------DKEAESRSCVSSNGFLVLFHGPHHHGCTGSGSSALSGNNLTLN 1289
             |....||::            |..|:...|::|.               .|....:.|::.:|:
  Rat  1334 THGEDHRQVMSSPALSMPLAMEDTTADPALCINSE---------------ESSLVEIDGDSESLS 1383

  Fly  1290 L---DAGAAGSHSAISPAKSHNS 1309
            |   |.|.......:||.|...|
  Rat  1384 LTACDYGEEALSQLVSPLKLQQS 1406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 27/145 (19%)
PLN02222 213..850 CDD:177868 216/696 (31%)
EF-hand_like 225..317 CDD:286375 16/91 (18%)
PI-PLCc_beta 317..702 CDD:176533 146/431 (34%)
C2_PLC_like 736..855 CDD:175974 43/131 (33%)
Plch1XP_017446352.2 PH-like 34..140 CDD:418428 24/114 (21%)
EFh_PI-PLCeta1 158..298 CDD:320050 30/172 (17%)
EF-hand motif 158..187 CDD:320050 6/31 (19%)
EF-hand motif 194..223 CDD:320050 7/48 (15%)
EF-hand motif 228..256 CDD:320050 6/29 (21%)
EF-hand motif 265..298 CDD:320050 8/37 (22%)
PI-PLCc_eta1 310..714 CDD:176569 146/431 (34%)
C2_PLC_like 744..868 CDD:175974 43/132 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345387
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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