DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcd3

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001099315.3	Gene:	Plcd3 / 287745	RGDID:	1310903	Length:	785	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	231/754 - (30%)
Similarity:	348/754 - (46%)	Gaps:	147/754 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 AQLWTDGLIKLAYSL------AQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDR 183
            ||.|..||.||...|      .:|:.....:|.:|.:      |:..::..|.|..|......|.
  Rat   156 AQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADS------DQDSKMSFKEIKSLLRMVNVDM 214

  Fly   184 K-----RVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMS 243
            .     |:.|..|.:.  :.:::...:..|        .:.|.:|.|:|.:|....|..  :.:|
  Rat   215 NDMYAYRLFKECDHSN--NERLEGAEIEAF--------LRRLLKRPELEEIFRRYSGED--RVLS 267

  Fly   244 IAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPI 308
            .::|:|||.....|.         |..|.|::|||.||.|:...|...::||||:.||:..:...
  Rat   268 ASELLEFLEDQGEDG---------ATLACAQKLIQTYELNETAKQHELMTLDGFMMYLLSPEGAA 323

  Fly   309 MAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEE 373
            :..:...:..||.||::||||:||||||||..|:.|.||.|.|.:....||||||||.|.|...|
  Rat   324 LNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFTQGCRCVELDCWEGPGGE 388

  Fly   374 PVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDK 438
            |||.||:|...:|..:||::|:.:.||..|.||||||.||||...||..:|.:.|.|.||||:.:
  Rat   389 PVIYHGHTLTSKILFRDVIQAVRDHAFTLSPYPVILSLENHCGLEQQIVMARHLRNILGDMLVTQ 453

  Fly   439 PLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKA 503
            .|||...|   :||.|..|:.::::|.||                  .|||.|
  Rat   454 ALDSQNPE---ELPSPEQLKCRVLVKGKK------------------LPAARN------------ 485

  Fly   504 AQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSED 568
                      |||                               :|....:|    .|.|....:
  Rat   486 ----------EDG-------------------------------RILSDRED----EDEDEEEAE 505

  Fly   569 ESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQ 633
            |:|...            |:.::..:...|:||||.|.......:.|.:....:..::.|..|::
  Rat   506 EALETA------------EQRKRAKQISPELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERK 558

  Fly   634 ATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGI 698
            |....:|....||.:|..||:||||.|.|..|:|:.||..||:|||||||||||....|.||.|.
  Rat   559 ARKFTREAGTSFVRHNTQQLTRVYPLGLRMTSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGR 623

  Fly   699 FEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTD---KRANTFVE--- 757
            |..|.:.||:|||.::|:.:...||    ...|....|:::.||:.|.|..   ::.|:.|:
  Rat   624 FLINGQCGYVLKPAYLRQLNTTFDP----ECPGPPRTTLTVQVLTAQQLPKLNVEKPNSIVDPLV 684

  Fly   758 -VDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE----EGGKLIG 817
             |::||:|.|...|:  |..|.:||.||.: |:...| ::..|||..:|....:    .....:|
  Rat   685 RVEIYGVPEDCAHKE--TDYVLNNGFNPCW-EQTLQF-QLRAPELVLVRFVVEDYDTTSPNDFVG 745

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            ...||:..|..||||::|.|:.|..::.|:||:.:.:::
  Rat   746 QFTLPLNSLKQGYRHIHLLSKDGASLSPATLFVHIRIEN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	9/25 (36%)
		PLN02222	213..850	CDD:177868	210/647 (32%)
		EF-hand_like	225..317	CDD:286375	26/91 (29%)
		PI-PLCc_beta	317..702	CDD:176533	134/384 (35%)
		C2_PLC_like	736..855	CDD:175974	39/129 (30%)
Plcd3	NP_001099315.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750