DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plch1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_006501593.1	Gene:	Plch1 / 269437	MGIID:	2683547	Length:	1694	Species:	Mus musculus

Alignment Length:	1391	Identity:	338/1391 - (24%)
Similarity:	571/1391 - (41%)	Gaps:	301/1391 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
Mouse    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||
Mouse    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:
Mouse   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|
Mouse   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            :::.:...|     ..::|.::|.::.|..|..|.::||..::......:..|...::..|||||
Mouse   257 KMSNVTLDY-----CLDIIMKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
Mouse   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            :||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.|..|.|   .|.|........||.
Mouse   382 RDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGILQDKL---DLSSVDTGECRQLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGV 518
            |..|:.||::|.||..:|            :|..|...:::..:|.|  ..:.......|...|.
Mouse   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSAD--EIEDECKFKLHYSNGT 494

  Fly   519 T---------------------RSTANGDVATGTGTGSAA--GTAGHAPPLQQIRQSSKDSTG-- 558
            |                     |...:.|..|......|.  |...|......:::|.|.|.|
Mouse   495 TEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRS 559

  Fly   559 ----------------SSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQ 607
                            |....:..||:||.|  |....|......:.::..:...|:|.||.|..
Mouse   560 LMANFGKHKQKATKSRSKSYSTDDEDDSLQN--PGKEGGQLYRLGRRRRTMKLCRELSDLVVYTN 622

  Fly   608 PIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQL 672
            .:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||||.|..
Mouse   623 SV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 684

  Fly   673 FWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTV 737
            :|||||||||||:|:....||:|...|:.|...||:|||:.|.:.  ..:||:...:.......:
Mouse   685 YWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKG--TFNPFSGDPLPANPKKQL 747

  Fly   738 SITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFV 792
            .:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||:: ||...
Mouse   748 ILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW-EETLT 809

  Fly   793 FKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVV 854
            | .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:|:.:.:
Mouse   810 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 868

  Fly   855 KDYVPDDLSNFAEALANP----IKYQSELEKRDIQ-LSVLTDEAEALGSADEDLSKSFVFVQVGG 914
            .:.    ...::..:.||    :.:....:.|.:| |..|.::.....|::.  :..:|
Mouse   869 NEI----FGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHASSEN--NSHYV------ 921

  Fly   915 QKKEL--RPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVS 977
            :|:.:  |.:...|::|..                     ||.:..:     ..|....:..|||
Mouse   922 RKRSIGDRILRRTASAPAK---------------------GRKKSKV-----GFQEMVEIKDSVS 960

  Fly   978 TSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKL---------ESLRKKHDKEKIKIA 1033
            .:.|       |.|.||......:    .|:...:.::|.|         |:.:....||.. :|
Mouse   961 EASR-------DQDGVLRRTTRSL----QVRPVSMPVDKSLLGALSLPISEAAKDTDGKENC-LA 1013

  Fly  1034 GQKSSPLEG----KKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADA 1094
            |.|....:|    |.|.|:..|   |:||:.|...|  |.              |:::...|:.:
Mouse  1014 GDKDDRRKGAATRKDPHFSNFN---KKLSSSSSALL--HK--------------DANQGPTASVS 1059

  Fly  1095 GEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKV------LKTSQTGQTK 1153
            ..:..||..:...|.:.: :.:.|:|..:..:.|..:.|.|:..|.:.:      :||::....:
Mouse  1060 NPEQCGGRGAKSERIKPN-MTNDCQENHNPPKFLSPRKHLALDPATKGLQERLHGMKTNEKEHAE 1123

  Fly  1154 QLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSV----VERGVAERVRLK 1214
            ........::|.|:.|    ...||:||        |..|.|...|:|.    |....::...|.
Mouse  1124 GFLGEKSMLSGSVLSQ----SSLEVENL--------EGSRAKGRAATSFSLSDVSALCSDIPDLH 1176

  Fly  1215 QTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLFHGPHHHGCTGSGSS 1279
            .|...:..|:....|.|             .|..|.:|.|.:|:   |:......:|....:..|
Mouse  1177 STAILQDTEISNLIDDV-------------TLTNENQSGSSISA---LIGQFEESNHPANVTVVS 1225

  Fly  1280 ALSGNNLTLNLDAGAAGSHSAISPAK 1305
            .||        .:||:||....:|.|
Mouse  1226 HLS--------TSGASGSAPFQTPFK 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/145 (19%)
		PLN02222	213..850	CDD:177868	212/690 (31%)
		EF-hand_like	225..317	CDD:286375	16/91 (18%)
		PI-PLCc_beta	317..702	CDD:176533	141/425 (33%)
		C2_PLC_like	736..855	CDD:175974	43/131 (33%)
Plch1	XP_006501593.1	PH-like	34..140	CDD:388408	24/114 (21%)
		EFh_PI-PLCeta1	158..298	CDD:320050	30/172 (17%)
		EF-hand motif	158..187	CDD:320050	6/31 (19%)
		EF-hand motif	194..223	CDD:320050	7/48 (15%)
		EF-hand motif	228..256	CDD:320050	6/29 (21%)
		EF-hand motif	265..298	CDD:320050	8/37 (22%)
		PI-PLCc_eta1	310..714	CDD:176569	141/425 (33%)
		C2_PLC_like	744..868	CDD:175974	43/132 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750