DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcd1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_006244125.1	Gene:	Plcd1 / 24655	RGDID:	3346	Length:	783	Species:	Rattus norvegicus

Alignment Length:	903	Identity:	271/903 - (30%)
Similarity:	407/903 - (45%)	Gaps:	228/903 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EKFIRWDDDSGTGTPVTMRVDAKGFFLYW-----VDQNNELDILDIATIRDVRTG-------QYA 76
            |:|.:..:|..|               .|     |.::.|..:..|..|::||.|       ::|
  Rat    39 ERFYKLQEDCKT---------------IWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFA 88

  Fly    77 KRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            :...:::...||....::||           |.:..:..:        ||.|..||.|:.:.
  Rat    89 RDIPEDRCFSIVFKDQRNTL-----------DLIAPSPAD--------AQHWVQGLRKIIHH--- 131

  Fly   142 LNGSAIMFLQKAH-TKLCL-QVDKSGRIPVKNIIKLFAQNKEDRKRVE---KALDVTGLPSG--- 198
             :||.....:..| ...|| :.||:            ..||.:.|.::   |.|::. :..|
  Rat   132 -SGSMDQRQKLQHWIHSCLRKADKN------------KDNKMNFKELKDFLKELNIQ-VDDGYAR 182

  Fly   199 ----KVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPR 259
                :.|.......:.|:....||.||||:|::|.|:...|::  :.:|:.:||.||...||:..
  Rat   183 KIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSA--ETLSVERLVTFLQHQQREEE 245

  Fly   260 LNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPM 324
                    |.||.|..||::|||::....:.|::.||||.||:..|....:.:...:..|||||:
  Rat   246 --------AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPL 302

  Fly   325 SHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAK 389
            |||.::|||||||...||||.||.|.|.:.|..||||:|||.|:|..:||:|.|||||..:|...
  Rat   303 SHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFC 367

  Fly   390 DVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPP 454
            |||.||.:.|||.|.||||||.||||:..||..:|.:.|.|.|.||||:|||.    ....||.|
  Rat   368 DVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPMLLDQPLDG----VTSSLPSP 428

  Fly   455 AMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVT 519
            ..|:.||::|.||.                                               ||:
  Rat   429 EQLKGKILLKGKKL-----------------------------------------------GGL- 445

  Fly   520 RSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSS--EDESLPNTTPNLPSGN 582
                   :..|...||                   ::|..||.|.::  |||::.:...:.|.
  Rat   446 -------LPAGGENGS-------------------EATDVSDEDEAAEMEDEAVRSQVQHKPK-- 482

  Fly   583 EPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRC-YEMSSFDEKQATTLLKERPIEFV 646
                   :.:.:...|:|.::.|.:.:||..|.:.....:. |||:||.|.:|..||:|....||
  Rat   483 -------EDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFV 540

  Fly   647 NYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKP 711
            .:|...|||:||||.|.||||:.|...||.|||:|||||||....|.:.||.|:.|...||:|||
  Rat   541 RHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

  Fly   712 EFMRRSDRRLDPFAESTVDGIIAG------TVSITVLSGQFL--TDKRANTFVE----VDMYGLP 764
            .|:|      ||........:..|      .:.:.::|||.|  .:|..|:.|:    |:::|:.
  Rat   606 AFLR------DPNTTFNSRALTQGPWWAPKRLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVG 664

  Fly   765 ADTVRKKFRTKTVRDNGM---------------------------NPLYDEEPFVFKKVVLPELA 802
            .||..:  :|..:.:||:                           ||.:|.| |.| :|.:|:||
  Rat   665 RDTASR--QTAVITNNGIVCVGSALGQAAGTVGPAVDMVSDLLGFNPRWDME-FEF-EVTVPDLA 725

  Fly   803 SIR--IAAYEEGGK--LIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            .:|  :..|:...|  .||...:|...|..|||||:|.|:.|.....|:||:.:.::|
  Rat   726 LVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	24/132 (18%)
		PLN02222	213..850	CDD:177868	230/682 (34%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	144/387 (37%)
		C2_PLC_like	736..855	CDD:175974	42/155 (27%)
Plcd1	XP_006244125.1	PH_PLC_delta	22..139	CDD:270169	26/137 (19%)
		PH	30..130	CDD:278594	24/124 (19%)
		EF-hand_10	159..208	CDD:291454	9/49 (18%)
		PLN02952	213..778	CDD:178538	225/671 (34%)
		EF-hand_like	213..295	CDD:286375	28/91 (31%)
		PI-PLCc_delta	295..596	CDD:176535	144/387 (37%)
		C2_PLC_like	628..782	CDD:175974	42/157 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750