DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcg2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_758489.1	Gene:	Plcg2 / 234779	MGIID:	97616	Length:	1265	Species:	Mus musculus

Alignment Length:	1289	Identity:	306/1289 - (23%)
Similarity:	467/1289 - (36%)	Gaps:	466/1289 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELD-ILDIATIRDVRTGQYAKR 78
            ::.:||:.|.....::....|....|:::..:...:.|....:::: .|||..|:::|.|   |.
Mouse    17 QIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEIKEIRPG---KN 78

  Fly    79 PKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
            .||.:..:.|.     ...|...|:.:|:.|| ::.::.....::.|..|..|| |:.:..| ::
Mouse    79 SKDFERAKAVR-----HKAECCFTILYGTQFV-LSTLSLATDSKEDAVKWLSGL-KILHQEA-MS 135

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALD--VTGLP--SGKVDSIS 204
            .|....::....|....||::.|    |.|.|     .:.|.:...::  |:|:.  ..|:..|.
Mouse   136 ASTPTMIESWLRKQIYSVDQTRR----NSISL-----RELKTILPLVNFKVSGIKFLKDKLVEIG 191

  Fly   205 VSK--FQFEDFYNLYKYL---TQRSEVERL-FDS---IVGNSKRKCMSIAQLVEF---------- 250
            ..|  ..||.|:..||.|   .|:|.::.. .||   |:||:.|...|...|.:|
Mouse   192 AQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQE 256

  Fly   251 -----LNKTQR------DPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGD 304
                 |||.:.      |..:.|...|:                        |.:|.||.||...
Mouse   257 LWAQDLNKVRERMTKFIDDTMRETAEPF------------------------LFVDEFLTYLFSR 297

  Fly   305 DNPIMAPSKLDLCD--DMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFW 367
            :|.|. ..|.|..|  ||:.|:|||:|:|||||||||.||..:||.|.|.:||.|||||:|||.|
Mouse   298 ENSIW-DEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCW 361

  Fly   368 NGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFG 432
            :|...:|:|.||:|...:|...||::||.:.||.||.:|||||.|.||:..||..:|...:|:.|
Mouse   362 DGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLG 426

  Fly   433 DMLLDKPLDSHPLEPNMD-LPPPAMLRRKIIIKNKK----------------------------- 467
            ||||.|     |.|.:.| ||.|:.||.|||||:||
Mouse   427 DMLLTK-----PTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGELYMWDS 486

  Fly   468 ------KHH-------------------------------HHHHHHHHKK--------------- 480
                  :|:                               |......|||
Mouse   487 IDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYC 551

  Fly   481 ---PAQVGTPAANNKLT-------------------------------------TANSV------ 499
               .|:.||.......|                                     |.||:
Mouse   552 AETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYYLTDNLTFNSIYALIQH 616

  Fly   500 -------------------------DAKAAQQVGLSASHEDGGVTRSTANGD--VATGTGTGSAA 537
                                     ::|......||....:..:.|...:|.  :....||.|.|
Mouse   617 YREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGTNSYA 681

  Fly   538 -----------------------GTAG--------------HA---------------------- 543
                                   ||:.              ||
Mouse   682 ITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNME 746

  Fly   544 --------------------PPLQQ------------------------IRQSSKDSTG------ 558
                                |.:.|                        |...||:..|
Mouse   747 RDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDY 811

  Fly   559 ---------------SSDSDSSSEDESLPNTTP-----------------NLPSG---------- 581
                           .|..|:...::.:....|                 ..|.|
Mouse   812 GTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFIL 876

  Fly   582 -----NEPPPEKA-------------------------------QKETEAGAEISALVNYVQPIH 610
                 .:||.|.|                               ::......|:|.||.|.:|..
Mouse   877 EPKKQGDPPVEFATDRVEELFEWFQSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTS 941

  Fly   611 FSS--FENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLF 673
            .:.  .||.:.:    |:.||.|.:|.::::::|::.:.||:..|:||||.|.|.||||:.|...
Mouse   942 KTKDHLENPDFR----EIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRL 1002

  Fly   674 WNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVS 738
            |..|.|:|||||||.|..||:|..:|..|.|:||:|:||.||  ..:.||....:...|:. |::
Mouse  1003 WLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMR--SEKYDPMPLESQRKILM-TLT 1064

  Fly   739 ITVLSGQFLTD---KRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLY--DEEPFVFKKVVL 798
            :.||..:.|..   ..|..||||::.|...|:  .||:|..|.|||::|::  .:|...| ::..
Mouse  1065 VKVLGARHLPKLGRSIACPFVEVEICGAEYDS--NKFKTTVVNDNGLSPVWAPTQEKVTF-EIYD 1126

  Fly   799 PELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVP 859
            |.||.:|...|||    ....:.|...|:.|:..|:|.|.|::...:.|.||||.:...::..:.
Mouse  1127 PNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLE 1191

  Fly   860 DDLSNFAEALANPIKYQS--ELEKRDIQLS---VLTDEAEALGSADED-LSKSF 907
            .:     |.|     |.|  :|.:|..:|:   .|.|..:.|..|:.| |.|.|
Mouse  1192 SE-----EEL-----YSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEF 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	26/125 (21%)
		PLN02222	213..850	CDD:177868	248/1019 (24%)
		EF-hand_like	225..317	CDD:286375	25/116 (22%)
		PI-PLCc_beta	317..702	CDD:176533	165/730 (23%)
		C2_PLC_like	736..855	CDD:175974	40/127 (31%)
Plcg2	NP_758489.1	PH_PLC_gamma	22..140	CDD:270168	27/128 (21%)
		PH-like	235..>276	CDD:302622	8/40 (20%)
		PI-PLCc_gamma	311..>458	CDD:176534	80/151 (53%)
		PH-like	475..>512	CDD:302622	1/36 (3%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	11/99 (11%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	13/102 (13%)
		SH3_PLCgamma2	773..827	CDD:212902	4/53 (8%)
		PHsplit_PLC_gamma	<840..909	CDD:270054	7/68 (10%)
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322	43/108 (40%)
		C2_PLC_like	1061..1187	CDD:175974	40/129 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750