DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCL2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001137854.1	Gene:	PLCL2 / 23228	HGNCID:	9064	Length:	1127	Species:	Homo sapiens

Alignment Length:	1136	Identity:	302/1136 - (26%)
Similarity:	490/1136 - (43%)	Gaps:	301/1136 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.:|::||||:.....:.|.:...::       |:...:|.:
Human   165 LDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQIS-------EDCAFSVIY 222

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGLIKL----AYSLAQLNGS---------AIMFLQKAHTKL 157
            |.::.::..|   ....|:|.:|..||..|    .::|..|..|         :.||.:
Human   223 GENYESLDLV---ANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSE------ 278

  Fly   158 CLQVDKSGRIPVKNII-------------KLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQ 209
             :.||..|.|.:.|.:             |:..:.||..|..:||            ...|:|
Human   279 -IDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA------------GTEVTK-- 328

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
             |:|..::..|..|.|:  .|..:..:|.::.:....|:.||...|....:||.:        :.
Human   329 -EEFIEVFHELCTRPEI--YFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEI--------SL 382

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTG 339
            |:|.:|||:|...:||.||:|||..|||..|..|..|....:|.||.||:|||||||||||||..
Human   383 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIE 447

  Fly   340 HQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSE 404
            .|..|.|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|::.|.:.||..||
Human   448 DQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASE 512

  Fly   405 YPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKNK 466
            ||:||..||||:.:||..:..:.:::.||.|       :...||::   ||.|.:|:.||:||.|
Human   513 YPLILCLENHCSIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAK 570

  Fly   467 KKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGT 531
            |                                       :..:.|..:|.||......:::...
Human   571 K---------------------------------------LSSNCSGVEGDVTDEDEGAEMSQRM 596

  Fly   532 GTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAG 596
            |                                 .|:...||..|             .|..:..
Human   597 G---------------------------------KENMEQPNNVP-------------VKRFQLC 615

  Fly   597 AEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGT 661
            .|:|.||:..:.:.|..|:.:.:..:.:|:.||:|..|:....|.|.:||||||..|:||:|:..
Human   616 KELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680

  Fly   662 RFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAE 726
            |.||||..||.||..|||:||:||||..|.|.||:|.|..|...||:|:|..||..........:
Human   681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTK 745

  Fly   727 STVDGIIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMN 783
            .:|.|:....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||..
Human   746 DSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVHQNGDA 808

  Fly   784 PLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIAL 845
            |::||. |.| ::.|||||.:|....::   |.:.||...:|...|..|||||.|:|..|:.:|.
Human   809 PIFDES-FEF-QINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAH 871

  Fly   846 ASLFLCVVV----------------------KDYVP---------DDLSNFAEALANPIKYQSEL 879
            ||||:.|.:                      ::|..         |::...|:.   ||:..::|
Human   872 ASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQP---PIRDATDL 933

  Fly   880 EKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVES--------LATSPKHRPSIS 936
             :.::|.:|:                ||         |||..:.|        ||.||:.
Human   934 -RENMQNAVV----------------SF---------KELCGLSSVANLMQCMLAVSPRF----- 967

  Fly   937 AAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQH---SLDQSVSTSIRQVESSQFDVDLVLAEPL 998
                             .|.|:..:|..::..|:   .|...|...::::.:: :|   ::.:.|
Human   968 -----------------LGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTT-YD---MMIQSL 1011

  Fly   999 EKILDH-KSVKEK-------RLEMEKKLESLRKKHDKEKIKIAGQKS--------SPLEGKKP-- 1045
            :.:::: .:|.||       .:|..:.|.|:..|...::.|:  ||:        :.|:|:..
Human  1012 KALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKL--QKAVESFTWNITILKGQADLL 1074

  Fly  1046 KFAITNKL--VKRLSNKSLNCLSPHSEPGVE 1074
            |:|....|  :|::...:::|  ..::||.|
Human  1075 KYAKNETLENLKQIHFAAVSC--GLNKPGTE 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	25/107 (23%)
		PLN02222	213..850	CDD:177868	212/650 (33%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	127/387 (33%)
		C2_PLC_like	736..855	CDD:175974	47/151 (31%)
PLCL2	NP_001137854.1	PH_PLC_eta	143..251	CDD:270170	23/95 (24%)
		EFh_PRIP2	271..414	CDD:320053	44/174 (25%)
		EF-hand motif	271..300	CDD:320053	7/35 (20%)
		EF-hand motif	307..339	CDD:320053	10/46 (22%)
		EF-hand motif	343..371	CDD:320053	6/29 (21%)
		EF-hand motif	380..414	CDD:320053	16/41 (39%)
		PI-PLCc_PRIP_metazoa	425..721	CDD:176539	127/387 (33%)
		C2_PLC_like	753..881	CDD:175974	47/131 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750