DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and PLCH1

DIOPT Version :9

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_005247295.1 Gene:PLCH1 / 23007 HGNCID:29185 Length:1705 Species:Homo sapiens


Alignment Length:1272 Identity:321/1272 - (25%)
Similarity:530/1272 - (41%) Gaps:280/1272 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
Human    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||                   
Human    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:        
Human   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|   
Human   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            ::|.:...|     ..::|:::|.::.|..|..|.::||..::......|..|...::..|||||
Human   257 KMNNVTTDY-----CLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
Human   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            :||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.||||.|....:|:...:   .||.
Human   382 RDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD------------------ 500
            |..|:.||::|.||..:|            :|..|...:::..:|.|                  
Human   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 496

  Fly   501 --------------AKAAQ------------QVGLSASHEDGGVTRSTANGDVATGTGTGSAAGT 539
                          .|.:|            :..|.|:|| |.......:.||       ..:|.
Human   497 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHE-GLNAHLKQSPDV-------KESGK 553

  Fly   540 AGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVN 604
            ..|...|.......|.:|.|.....|::||.....:.....|......:.:|..:...|:|.||.
Human   554 KSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVV 618

  Fly   605 YVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFM 669
            |...:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||||.
Human   619 YTNSV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFN 680

  Fly   670 PQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIA 734
            |..:|||||||||||:|:....||||...|:.|...||:|||:.|.:.  ..:||:...:.....
Human   681 PLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKG--TFNPFSGDPLPANPK 743

  Fly   735 GTVSITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEE 789
            ..:.:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||:: ||
Human   744 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW-EE 805

  Fly   790 PFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLC 851
            ...| .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:|:.
Human   806 TLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVH 864

  Fly   852 VVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGG-- 914
            :.:.:.    ...::..:.||                                 |:..:...|  
Human   865 ITINEI----YGKWSPLILNP---------------------------------SYTILHFLGAT 892

  Fly   915 QKKELRPVESLAT-SPKHRPSISAA---AAMSV-DVTVDRTDG----GRGEDSISIVAPSIQHQH 970
            :.::|:.::.|.. :|:|..|.:.:   ...|: |..:.||..    ||.:..:     ..|...
Human   893 KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKM-----GFQEMV 952

  Fly   971 SLDQSVSTSIRQVESSQFDVDLVL--------AEPLEKILDHK-------SVKEKRLEMEKKLES 1020
            .:..|||.:.|       |.|.||        |.|:...:|..       .|.|...::|.|..|
Human   953 EIKDSVSEATR-------DQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENS 1010

  Fly  1021 LRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDS 1085
            |.:..|       |::......|.|.|...|   |:||:.|...|  |.:         ...||:
Human  1011 LAEDKD-------GRRKGKASIKDPHFLNFN---KKLSSSSSALL--HKD---------TSQGDT 1054

  Fly  1086 SEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYH---EAIYSAAEKV--LK 1145
            ...:|......:..|.||...||| .|...|.|:|.....:.|..|.|   :.:.:..:.:  :|
Human  1055 IVSTAHMSVTGEQLGMSSPRGGRT-TSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVK 1118

  Fly  1146 TSQTGQTKQLKASLDKVTGEVMHQLQEARRN-EVKNL 1181
            ..:.|..:........::|.|:     :..| |:|||
Human  1119 IKEKGNPEDFVEGKSILSGSVL-----SHSNLEIKNL 1150

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 27/145 (19%)
PLN02222 213..850 CDD:177868 215/693 (31%)
EF-hand_like 225..317 CDD:286375 18/91 (20%)
PI-PLCc_beta 317..702 CDD:176533 142/428 (33%)
C2_PLC_like 736..855 CDD:175974 43/131 (33%)
PLCH1XP_005247295.1 PH-like 34..140 CDD:302622 24/114 (21%)
EFh 158..224 CDD:238008 14/88 (16%)
EF-hand_7 159..220 CDD:290234 12/83 (14%)
PLN02228 239..884 CDD:177873 213/726 (29%)
EF-hand_like 239..310 CDD:286375 16/78 (21%)
PI-PLCc_eta1 310..713 CDD:176569 142/428 (33%)
AANH_like <453..554 CDD:294206 18/120 (15%)
C2_PLC_like 743..867 CDD:175974 43/132 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151868
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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