DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcl1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001108135.1	Gene:	Plcl1 / 227120	MGIID:	3036262	Length:	1096	Species:	Mus musculus

Alignment Length:	1157	Identity:	301/1157 - (26%)
Similarity:	475/1157 - (41%)	Gaps:	294/1157 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TMRVDAKGFFLYWVDQNNELD--ILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVT 102
            |:..|.:.  |.|.....:|:  .|||:.|:::|.|:..:..::|.|...:       .|:...:
Mouse   137 TLDTDLQA--LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCAFS 192

  Fly   103 VCHGSDFVNMTFVNFCCTRRDIAQLWTDGL-------------------------IKLAYSLAQL 142
            :.||.::.::..|   ....|:|.:|..||                         :|..:..|.:
Mouse   193 ILHGENYESLDLV---ANSADVANIWVSGLRYLVSRSKQPLDFIEGNQNTPRFMWLKTVFEAADV 254

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            :|:.|| |:....:|..|::     |.....|:..:.||.:|..||.               .::
Mouse   255 DGNGIM-LEDTSVELIKQLN-----PTLKESKIRLKFKEIQKSKEKL---------------TTR 298

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPAR 272
            ...|:|...:..|..|.||..|...|..|  ::.:....|:.||...|....:.|.:
Mouse   299 VTEEEFCEAFCELCTRPEVYFLLVQISKN--KEYLDANDLMLFLEAEQGVTHITEDM-------- 353

  Fly   273 AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYL 337
            ..::|::||.::...|||.|::|||.:||:..:..|..|.:..:..||.||:|||:||:||||||
Mouse   354 CLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 418

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ...|..|.:.:..|.:.|..|||.:|||..:|...||::.:.......:..:.|||.|.:.||..
Mouse   419 IEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMHLSFRSVLEVINKFAFVA 483

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK 467
            ||||:||...|||:..||..:|...:::||:.|..:.    ||.....||.|..|:..||:|.||
Mouse   484 SEYPLILCLGNHCSLPQQKVMAQQMKKVFGEKLYTEA----PLSSESYLPSPEKLKNMIIVKGKK 544

  Fly   468 KHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTG 532
                              .|:.::.|                     :|.||......:::
Mouse   545 ------------------LPSESDLL---------------------EGEVTDEDEEAEMS---- 566

  Fly   533 TGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGA 597
                             |:.|.|..|.                              ||......
Mouse   567 -----------------RRMSGDYNGE------------------------------QKHIWLCR 584

  Fly   598 EISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTR 662
            |:|.||:..:.:....||.:.|....:||.||.|.:|:.:..|.|.:||||||..||||||:..|
Mouse   585 ELSDLVSICKSVQHRDFELSMKTQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRVYPSAMR 649

  Fly   663 FDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAES 727
            .||||..||.|||.|||:||:||||....|.|:.|.|..|...||:|:|..||..........:.
Mouse   650 IDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKG 714

  Fly   728 TVDGIIAGTVSITVLSGQ-FLTDKRA-------NTFVEVDMYGLPADTVRKKFRTKTVRDNGMNP 784
            .|.|:....:.|.::||| |...|.|       :.:|.|:::|:|||...:  |||||:.|..||
Mouse   715 IVPGVSPLVLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCCEQ--RTKTVQQNSDNP 777

  Fly   785 LYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALA 846
            ::| |.|.| :|.||||..:|....::   |.:.||...:|...|.||||||.|||.||..:...
Mouse   778 IFD-ETFEF-QVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHV 840

  Fly   847 SLFLCVVVKDY----VPDDLSNFAEALANPIKYQSELEKRDIQLSVLTD--------EAEALGSA 899
            :||:.:.:.:.    .|...| .:..:...::..:.|  |:|.|..:.|        ..||: ..
Mouse   841 TLFVHIAITNRSGGGKPQKRS-LSVRMGKKVREYTML--RNIGLKTIDDIFKIAVHPLREAI-DM 901

  Fly   900 DEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIV-- 962
            .|::..:.|.|      |||..:..:|:..:...::|:..     :|.|.|      .|:|:|
Mouse   902 RENMQNAIVSV------KELCGLPPIASLKQCLLTLSSRL-----ITSDST------PSVSLVMK 949

  Fly   963 -----------APSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEK 1016
                       .|.:|.            |.:.:    .||::.|....|....:|:||.::.:|
Mouse   950 DCFPYLEPLGAIPDVQK------------RMLAA----YDLMIQESRVLIEMADTVQEKIVQCQK 998

  Fly  1017 K-LESLRKKHDKEKIKIAGQKSSPLEGKKPKFAI--------------------TNKLVKRLSNK 1060
            . :|...:.|:      .|.|.. |:|:|...||                    .|:.|:.:...
Mouse   999 AGMEFHEELHN------LGAKEG-LKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQI 1056

  Fly  1061 SLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQES 1112
            .|.|||           |.|..|.              .|||.:...|:.|:
Mouse  1057 QLACLS-----------CGLSKGP--------------GGGSEAKGKRSLEA 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	24/131 (18%)
		PLN02222	213..850	CDD:177868	205/647 (32%)
		EF-hand_like	225..317	CDD:286375	24/91 (26%)
		PI-PLCc_beta	317..702	CDD:176533	121/384 (32%)
		C2_PLC_like	736..855	CDD:175974	49/129 (38%)
Plcl1	NP_001108135.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		Interaction with PPP1C. /evidence=ECO:0000250	83..222		22/96 (23%)
		PH_PLC_eta	116..224	CDD:270170	22/98 (22%)
		PH	119..224	CDD:278594	22/98 (22%)
		EF-hand_like	316..397	CDD:286375	24/90 (27%)
		PLN02228	331..851	CDD:177873	198/625 (32%)
		PI-PLCc_PRIP_metazoa	399..689	CDD:176539	121/383 (32%)
		Interaction with GABA A beta subunit. /evidence=ECO:0000250	544..568		6/83 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..569		5/60 (8%)
		C2_PLC_like	721..849	CDD:175974	49/131 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1067..1096		6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750