DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcl2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_038908.2	Gene:	Plcl2 / 224860	MGIID:	1352756	Length:	1128	Species:	Mus musculus

Alignment Length:	855	Identity:	257/855 - (30%)
Similarity:	387/855 - (45%)	Gaps:	182/855 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.:|::||||:.....:.|.:.:.::       |:...:|.:
Mouse   166 LDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQIS-------EDCAFSVIY 223

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGLIKL----AYSLAQLNGS---------AIMFLQ-----K 152
            |.::.::..|   ....|:|.:|..||..|    .::|..|..|         :.||.:     .
Mouse   224 GENYESLDLV---ANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGL 285

  Fly   153 AHTKLCLQVD---------KSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKF 208
            .|..||..|.         |:.:|.:|            .|.:.|:.|..|....|
Mouse   286 GHITLCHAVQCIRNLNPGLKTSKIELK------------FKELHKSKDKAGTEITK--------- 329

  Fly   209 QFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARA 273
              |:|..::..|..|.|:  .|..:..:|.::.:....|:.||...|....:||.:        :
Mouse   330 --EEFIEVFHELCTRPEI--YFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEI--------S 382

  Fly   274 KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            .|:|.:|||:|...:||.||:|||..|||..|..|..|....:|.||.||:|||||||||||||.
Mouse   383 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLI 447

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTS 403
            ..|..|.|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|::.|.:.||..|
Mouse   448 EDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFAS 512

  Fly   404 EYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKN 465
            |||:||..||||:.:||..:..:.::|.||.|       :...|||:   ||.|.:|:.||:||.
Mouse   513 EYPLILCLENHCSIKQQKVMVQHMKKILGDKL-------YTTSPNMEESYLPSPDVLKGKILIKA 570

  Fly   466 KKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATG 530
            ||                                       :..:.|..:|.||......:::..
Mouse   571 KK---------------------------------------LSSNCSGVEGDVTDEDEGAEMSQR 596

  Fly   531 TGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEA 595
            .|                                 .|:...||..|             .|..:.
Mouse   597 MG---------------------------------KENVEQPNHVP-------------VKRFQL 615

  Fly   596 GAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAG 660
            ..|:|.||:..:.:.|..|:.:.:..:.:|:.||:|..|:....|.|.:||||||..|:||:|:.
Mouse   616 CKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSP 680

  Fly   661 TRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFA 725
            .|.||||..||.||..|||:||:||||..|.|.||:|.|..|...||:|:|..||..........
Mouse   681 MRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANT 745

  Fly   726 ESTVDGIIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGM 782
            :.:|.|:....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||.
Mouse   746 KDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVNQNGD 808

  Fly   783 NPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIA 844
            .|::||. |.| ::.|||||.:|....::   |.:.||...:|...|..|||||.|:|..|:.:|
Mouse   809 APIFDES-FEF-QINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLA 871

  Fly   845 LASLFLCVVV 854
            .||||:.|.:
Mouse   872 HASLFVHVAI 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	25/107 (23%)
		PLN02222	213..850	CDD:177868	214/650 (33%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	129/387 (33%)
		C2_PLC_like	736..855	CDD:175974	47/130 (36%)
Plcl2	NP_038908.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..129
		PH_PLC_eta	144..252	CDD:270170	23/95 (24%)
		EFh_PRIP2	272..415	CDD:320053	43/175 (25%)
		EF-hand motif	272..301	CDD:320053	6/28 (21%)
		EF-hand motif	308..340	CDD:320053	9/54 (17%)
		EF-hand motif	344..372	CDD:320053	6/29 (21%)
		EF-hand motif	381..415	CDD:320053	16/41 (39%)
		PI-PLCc_PRIP_metazoa	426..722	CDD:176539	129/387 (33%)
		C2_PLC_like	754..882	CDD:175974	47/132 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1128
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750