DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcg1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_067255.2	Gene:	Plcg1 / 18803	MGIID:	97615	Length:	1302	Species:	Mus musculus

Alignment Length:	1223	Identity:	285/1223 - (23%)
Similarity:	419/1223 - (34%)	Gaps:	489/1223 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LDIATIRDVRTGQYAKRPKD-NKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIA 125
            :||..|:::|.|   |..:| ::.::.....|.   :.....:.:|.:| .:..::...|..|..
Mouse    73 IDIREIKEIRPG---KTSRDFDRYQEDPAFRPD---QSHCFVILYGMEF-RLKTLSLQATSEDEV 130

  Fly   126 QLWTDGLI--------------------KLAYS-----------------LAQLNGSA--IMFLQ 151
            .:|..||.                    |..||                 |:|:|...  :.||:
Mouse   131 NMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLR 195

  Fly   152 KAHTKLCLQVDKSGRIPVKNIIKLF------AQNKEDRKRVEKALDVTGLPSG-KVDSISVSKFQ 209
            :..|.|   ..:||.|......:|:      ||...|.    ..|:...|.:| :.:...||..:
Mouse   196 ERLTDL---EQRSGDITYGQFAQLYRSLMYSAQKTMDL----PFLETNALRTGERPEHCQVSLSE 253

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            |:.|  |.:|..:...|:||                |:.||:....||| |.||..||
Mouse   254 FQQF--LLEYQGELWAVDRL----------------QVQEFMLSFLRDP-LREIEEPY------- 292

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLD-LC-DDMDQPMSHYFINSSHNTYL 337
                             ..||..:.:|...:|.:. .|:|| :| |.|:.|:|||:|:|||||||
Mouse   293 -----------------FFLDELVTFLFSKENSVW-NSQLDAVCPDTMNNPLSHYWISSSHNTYL 339

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ||.|.:.:||:|.|.:||..||||:|||.|:|....|||.||:|...:|...|||..|.|.||..
Mouse   340 TGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVA 404

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK 467
            ||||||||.|:||:..||..:|.:.|::.||.||.||:|.    ....||.|..|||||:||:||
Mouse   405 SEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDI----AADGLPSPNQLRRKILIKHKK 465

  Fly   468 ------------------------------------KHHHHHHH--------------------- 475
                                                .|..:.|:
Mouse   466 LAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNE 530

  Fly   476 --------------------HHHKKPA-----------------QVGTPAA-------------- 489
                                .|.|..|                 :.|.|..
Mouse   531 DEEEPKEASSSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDY 595

  Fly   490 ------NNKL--------------------------------------TTANSVDAKAAQQVGLS 510
                  |.|:                                      ...|..:.:.::.|..:
Mouse   596 TLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT 660

  Fly   511 ASHED-----GGVTRSTANGDVATGTGTGS-----------------AAGTAGHAPPLQQ----- 548
            .:||.     ..:||:.|...:......|:                 |.|...|....|:
Mouse   661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVM 725

  Fly   549 ------------------------------IRQSSKDSTGSSDSD-------------------- 563
                                          |.:.:.:..|:::.|
Mouse   726 LGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMP 790

  Fly   564 -------------SSSEDE---------------------------------------------- 569
                         :..|||
Mouse   791 TFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVL 855

  Fly   570 --SLPNTTPNLPSGN------EPP----------------------PEKAQKETEAGA------- 597
              ...:...|.|.|:      :.|                      |..||...:..|
Mouse   856 EPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQ 920

  Fly   598 -------------------------------EISALVNYVQPIHFSSFENAEKKNRCY-EMSSFD 630
                                           |:|.||.|.:|:.|.. |....:..|| :||||.
Mouse   921 DWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSFP 984

  Fly   631 EKQATTLL-KERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQL 694
            |.:|...: |.:..:|:.||:.||||:||.|.|.||||:.|...|..|.|||||||||.|..||:
Mouse   985 ETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQM 1049

  Fly   695 NLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN---TFV 756
            |..:|......||:|:|..||  |...|||.:|::.|:....:.|.||..:.|......   .||
Mouse  1050 NQALFMAGGHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFV 1112

  Fly   757 EVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE----GGKLIG 817
            |:::.|...|:.::|  |:.|.|||:||::..:||.| ::..||.|.:|...|||    ....:.
Mouse  1113 EIEVAGAEYDSTKQK--TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLA 1174

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVP----DDLSNFA 866
            ....||.||..|||.|.|::...:.:.||||.:.:   |..|    .|||.|:
Mouse  1175 QATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKI---DIFPAKENGDLSPFS 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	21/120 (18%)
		PLN02222	213..850	CDD:177868	241/1003 (24%)
		EF-hand_like	225..317	CDD:286375	21/92 (23%)
		PI-PLCc_beta	317..702	CDD:176533	165/743 (22%)
		C2_PLC_like	736..855	CDD:175974	40/125 (32%)
Plcg1	NP_067255.2	PH_PLC_gamma	29..151	CDD:270168	15/84 (18%)
		PH	<71..142	CDD:278594	15/75 (20%)
		PI-PLCc_gamma	319..>466	CDD:176534	79/150 (53%)
		PH-like	489..>523	CDD:302622	2/33 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..545		0/22 (0%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	8/103 (8%)
		SH2_C-SH2_PLC_gamma_like	663..765	CDD:198186	11/101 (11%)
		SH3_PLCgamma1	791..850	CDD:212903	3/58 (5%)
		PHsplit_PLC_gamma	<864..933	CDD:270054	8/68 (12%)
		PH	<872..929	CDD:278594	5/56 (9%)
		PLCYc	954..1069	CDD:128454	52/115 (45%)
		C2_PLC_like	1087..1211	CDD:175974	40/129 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750