DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and Plcd1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001280577.1 Gene:Plcd1 / 18799 MGIID:97614 Length:782 Species:Mus musculus


Alignment Length:878 Identity:262/878 - (29%)
Similarity:402/878 - (45%) Gaps:205/878 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EKFIRWDDDSGTGTPVTMRVDAKGFFLYW-----VDQNNELDILDIATIRDVRTG-------QYA 76
            |:|.:..:|..|               .|     |.::.|..:..|..|::||.|       ::|
Mouse    65 ERFYKLQEDCKT---------------IWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFA 114

  Fly    77 KRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            :...:::...||....::||           |.:       ..:..|: |.|..||.|:      
Mouse   115 RDIPEDRCFSIVFKDQRNTL-----------DLI-------APSPADV-QHWVQGLRKI------ 154

  Fly   142 LNGSAIMFLQKAHTKLCLQVDKSGRIP--------VKNIIKLFAQNKEDRKRVEKALDVTGLPSG 198
                               :|:||.:.        :.:.::...:||:::...::..|.....:.
Mouse   155 -------------------IDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNV 200

  Fly   199 KVDSISVSK------------FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFL 251
            :||.....|            .:.|:....|:.||||:|::|.|....|::  :.:|:.:||.||
Mouse   201 QVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSA--ETLSVEKLVTFL 263

  Fly   252 NKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDL 316
            ...||:..        |.||.|..||::|||::....:.|::.||||.||:..|....:.:...:
Mouse   264 QHQQREEE--------AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRV 320

  Fly   317 CDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYT 381
            ..||:||:|||.::|||||||...||||.||.|.|.:.|..||||:|||.|:|..:||:|.||||
Mouse   321 YQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYT 385

  Fly   382 FVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLE 446
            |..:|...|||.||.:.|||.|.||||||.||||:..||..:|::.|.|.|.||||:|||.    
Mouse   386 FTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDG---- 446

  Fly   447 PNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSA 511
            ....||.|..|:.||::|.||.                                           
Mouse   447 VTTSLPSPEQLKEKILLKGKKL------------------------------------------- 468

  Fly   512 SHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSS--EDESLPNT 574
                ||:.               .|.|            ::..::|..||.|.::  |||::.:.
Mouse   469 ----GGLL---------------PAGG------------ENGPEATDVSDEDEAAEMEDEAVRSQ 502

  Fly   575 TPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRC-YEMSSFDEKQATTLL 638
            ..:.|.         :.:.:...|:|.:|.|.:.:||..|.:.....:. |||:||.|.:|..||
Mouse   503 VQHKPK---------EDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLL 558

  Fly   639 KERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNA 703
            :|....||.:|...|||:||||.|.||||:.|...||.|||:|||||||....|.:.||.|:.|.
Mouse   559 QESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNG 623

  Fly   704 RSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVE----VDMYG 762
            ..||:|||.|:|..|...:..|.:.........:.:.::|||.|  .:|..|:.|:    |:::|
Mouse   624 GCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHG 688

  Fly   763 LPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIR--IAAYEEGGK--LIGHRVLPV 823
            :..|...:  :|..:.:||.||.:|.| |.| .|.:|:||.:|  :..|:...|  .||...:|.
Mouse   689 VGQDVASR--QTAVITNNGFNPRWDTE-FEF-VVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 749

  Fly   824 IGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            ..|..|||||:|.|:.|.....|:||:.:.::|
Mouse   750 NSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 24/132 (18%)
EFh_PI-PLC21 151..305 CDD:320043 42/173 (24%)
EF-hand motif 151..180 CDD:320043 3/36 (8%)
EF-hand motif 187..216 CDD:320043 5/40 (13%)
EF-hand motif 225..255 CDD:320043 9/29 (31%)
EF-hand motif 272..305 CDD:320043 13/32 (41%)
PI-PLCc_beta 317..702 CDD:176533 143/387 (37%)
C2_PLC_like 736..855 CDD:175974 41/128 (32%)
PTZ00121 <981..>1253 CDD:173412
Plcd1NP_001280577.1 PH_PLC_delta 48..165 CDD:270169 27/158 (17%)
EFh_PI-PLCdelta1 170..309 CDD:320047 39/148 (26%)
EF-hand motif 170..199 CDD:320047 3/28 (11%)
EF-hand motif 206..235 CDD:320047 3/28 (11%)
EF-hand motif 239..270 CDD:320047 11/32 (34%)
EF-hand motif 276..309 CDD:320047 13/32 (41%)
PI-PLCc_delta 321..622 CDD:176535 143/387 (37%)
C2_PLC_like 654..781 CDD:175974 41/130 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.