DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcd1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001280577.1	Gene:	Plcd1 / 18799	MGIID:	97614	Length:	782	Species:	Mus musculus

Alignment Length:	878	Identity:	262/878 - (29%)
Similarity:	402/878 - (45%)	Gaps:	205/878 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EKFIRWDDDSGTGTPVTMRVDAKGFFLYW-----VDQNNELDILDIATIRDVRTG-------QYA 76
            |:|.:..:|..|               .|     |.::.|..:..|..|::||.|       ::|
Mouse    65 ERFYKLQEDCKT---------------IWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFA 114

  Fly    77 KRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            :...:::...||....::||           |.:       ..:..|: |.|..||.|:
Mouse   115 RDIPEDRCFSIVFKDQRNTL-----------DLI-------APSPADV-QHWVQGLRKI------ 154

  Fly   142 LNGSAIMFLQKAHTKLCLQVDKSGRIP--------VKNIIKLFAQNKEDRKRVEKALDVTGLPSG 198
                               :|:||.:.        :.:.::...:||:::...::..|.....:.
Mouse   155 -------------------IDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNV 200

  Fly   199 KVDSISVSK------------FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFL 251
            :||.....|            .:.|:....|:.||||:|::|.|....|::  :.:|:.:||.||
Mouse   201 QVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSA--ETLSVEKLVTFL 263

  Fly   252 NKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDL 316
            ...||:..        |.||.|..||::|||::....:.|::.||||.||:..|....:.:...:
Mouse   264 QHQQREEE--------AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRV 320

  Fly   317 CDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYT 381
            ..||:||:|||.::|||||||...||||.||.|.|.:.|..||||:|||.|:|..:||:|.||||
Mouse   321 YQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYT 385

  Fly   382 FVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLE 446
            |..:|...|||.||.:.|||.|.||||||.||||:..||..:|::.|.|.|.||||:|||.
Mouse   386 FTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDG---- 446

  Fly   447 PNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSA 511
            ....||.|..|:.||::|.||.
Mouse   447 VTTSLPSPEQLKEKILLKGKKL------------------------------------------- 468

  Fly   512 SHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSS--EDESLPNT 574
                ||:.               .|.|            ::..::|..||.|.::  |||::.:.
Mouse   469 ----GGLL---------------PAGG------------ENGPEATDVSDEDEAAEMEDEAVRSQ 502

  Fly   575 TPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRC-YEMSSFDEKQATTLL 638
            ..:.|.         :.:.:...|:|.:|.|.:.:||..|.:.....:. |||:||.|.:|..||
Mouse   503 VQHKPK---------EDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLL 558

  Fly   639 KERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNA 703
            :|....||.:|...|||:||||.|.||||:.|...||.|||:|||||||....|.:.||.|:.|.
Mouse   559 QESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNG 623

  Fly   704 RSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVE----VDMYG 762
            ..||:|||.|:|..|...:..|.:.........:.:.::|||.|  .:|..|:.|:    |:::|
Mouse   624 GCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHG 688

  Fly   763 LPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIR--IAAYEEGGK--LIGHRVLPV 823
            :..|...:  :|..:.:||.||.:|.| |.| .|.:|:||.:|  :..|:...|  .||...:|.
Mouse   689 VGQDVASR--QTAVITNNGFNPRWDTE-FEF-VVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 749

  Fly   824 IGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            ..|..|||||:|.|:.|.....|:||:.:.::|
Mouse   750 NSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	24/132 (18%)
		PLN02222	213..850	CDD:177868	226/649 (35%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	143/387 (37%)
		C2_PLC_like	736..855	CDD:175974	41/128 (32%)
Plcd1	NP_001280577.1	PH_PLC_delta	48..165	CDD:270169	27/158 (17%)
		PH	56..155	CDD:278594	24/148 (16%)
		EF-hand_10	185..234	CDD:291454	6/48 (13%)
		PLN02952	239..777	CDD:178538	222/638 (35%)
		EF-hand_like	239..321	CDD:286375	28/91 (31%)
		PI-PLCc_delta	321..622	CDD:176535	143/387 (37%)
		C2_PLC_like	654..781	CDD:175974	41/130 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3066
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.700