DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcb1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_001139302.1	Gene:	Plcb1 / 18795	MGIID:	97613	Length:	1216	Species:	Mus musculus

Alignment Length:	1266	Identity:	507/1266 - (40%)
Similarity:	729/1266 - (57%)	Gaps:	158/1266 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPK 80
            |..:|:.|.||::|||||...||:.:|.|.:|||.||.|||.|.::||::.::|.|.|::||.||
Mouse    18 VSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPK 82

  Fly    81 DNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGS 145
            |.|||:::.:|....||::.:||.:|.|.||::.:|....:.::|:.||:.:..||.:|...|.|
Mouse    83 DPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMS 147

  Fly   146 AIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQF 210
            ...||:||:|||.|||...||||:|||.:||:   .||||||.||:...|||.:.|||....|.
Mouse   148 RDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFS---ADRKRVETALEACSLPSSRNDSIPQEDFT- 208

  Fly   211 EDFYNLY-KYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            .|.|.:: ..|..|.|::.:| |..|...:..:::.|:::|:|..||||||||||||.....:.:
Mouse   209 PDVYRVFLNNLCPRPEIDNIF-SEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTG 339
            .||::||||...|:|||:|:|||:|||.|::|.:::|.||||.:||.||:||||||||||||||.
Mouse   273 VLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTA 337

  Fly   340 HQLTGKSSVEIYRQCLLAGCRCVELDFWNGRT--EEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            .||.|.||||:|||.||:||||||||.|.|||  |||||.||:|...||..|:|:|||||.||||
Mouse   338 GQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKT 402

  Fly   403 SEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNK 466
            |.:|::||||||. :|:||||:|.|||.||||.||.:||:.:|||..:.||.|..|..||::|||
Mouse   403 SPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNK 467

  Fly   467 KKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGT 531
            ||.|........||.::    .|:|..:.::||
Mouse   468 KKSHKSSEGSGKKKLSE----QASNTYSDSSSV-------------------------------- 496

  Fly   532 GTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAG 596
                              .:.|....|.:|::|..:|:.......::..|.      |..|..|.
Mouse   497 ------------------FEPSSPGAGEADTESDDDDDDDDCKKSSMDEGT------AGSEAMAT 537

  Fly   597 AEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGT 661
            .|:|.||||:||:.|.|||.::|:|:.:|||||.|.:....|.:.|:|||.|||.||||:||.||
Mouse   538 EEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGT 602

  Fly   662 RFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAE 726
            |.||||:|||||||||||:|||||||:|||||:|:|::|||.:|||.||||||||.|:..|||.|
Mouse   603 RVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTE 667

  Fly   727 STVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPF 791
            ..||||:|.|:|:.::|||||:||:..|:|||||:|||.||.||.|:|||.:.|.:||:::|||.
Mouse   668 GIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPI 732

  Fly   792 VFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            ||||||||.||.:||||||||||.||||:|||..:.|||.::.||:|..||:.|.::|:.:.|||
Mouse   733 VFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKD 797

  Fly   857 YVPDDLSNFAEALANPIKYQSELEKRDIQLSVLT--DEAEALGSADEDLSKSFVFVQVGGQKKEL 919
            ||||..::..|||:|||:|.:.:|:|..||:.||  ||.|.                    |||.
Mouse   798 YVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEV--------------------KKEA 842

  Fly   920 RPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVE 984
            .|.|:.:.:|....:               |....|.:..:.:||....|....|....|::...
Mouse   843 DPGETSSEAPSETRT---------------TPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPA 892

  Fly   985 SSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAI 1049
            .::..:..||.|     ::.::::|  |:.:|....|:|||.||
Mouse   893 KTEDLIQSVLTE-----VEAQTIEE--LKQQKSFVKLQKKHYKE--------------------- 929

  Fly  1050 TNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRL 1114
            ...||||...|:...:..|:....||....|....:.|:||..|:.:.....|........|..|
Mouse   930 MKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDL 994

  Fly  1115 RSACREYTSQYREL------------QEKYHEAIYSAAE----------KVLKTSQTGQTKQLKA 1157
            .:...|.|.:..:|            ||:|:...|...|          .|.:..|..|.|:||.
Mouse   995 AALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKE 1059

  Fly  1158 SLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTD 1222
            ..:|...|:..::.:.|:.::....:  :|:.::...|.|:..|.::..|....||::...:|.:
Mouse  1060 ICEKEKKELKKKMDKKRQEKITEAKS--KDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQE 1122

  Fly  1223 ELQKQHDSVRNALAEHRSKARQILDKEAESR 1253
            :|.::|:.:|..:.:.:.|.:..|::|.:.:
Mouse  1123 KLVEKHNEIRQQILDEKPKLQTELEQEYQDK 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	52/124 (42%)
		PLN02222	213..850	CDD:177868	322/640 (50%)
		EF-hand_like	225..317	CDD:286375	42/91 (46%)
		PI-PLCc_beta	317..702	CDD:176533	185/387 (48%)
		C2_PLC_like	736..855	CDD:175974	69/118 (58%)
Plcb1	NP_001139302.1	PH_PLC_beta	22..148	CDD:270167	52/125 (42%)
		PLN02952	216..784	CDD:178538	319/628 (51%)
		EF-hand_like	224..314	CDD:286375	41/90 (46%)
		PI-PLCc_beta	316..643	CDD:176533	185/386 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..534		15/124 (12%)
		C2_PLC_like	677..796	CDD:175974	69/118 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..891		16/91 (18%)
		DUF1154	903..939	CDD:284131	14/63 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	967..989		5/21 (24%)
		PLC-beta_C	1003..1172	CDD:285865	29/153 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1095		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1173..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841988
Domainoid	1	1.000	203	1.000	Domainoid score	I2951
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22876
Inparanoid	1	1.050	882	1.000	Inparanoid score	I401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47559
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		otm42693
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	1	1.100	-	-	LDO	PTHR10336
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3114
SonicParanoid	1	1.000	-	-		X1825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800