Protein Alignment Plc21C and pll-1

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_741068.1
• Gene: pll-1 / 187273
• WormBaseID: WBGene00004045
• Length: 1075
• Species: Caenorhabditis elegans
• Alignment Length: 1160
• Identity: 270/1160 - (23%)
• Similarity: 431/1160 - (37%)
• Gaps: 294/1160 - (25%)

  Fly    20 LQDGEKFIRWDDDSGTGTPVTMR----VDAKGFFLYWVDQNNELDILDIA--TIRDVRTGQYAK- 77
            :|.|..|::.     .||....|    :||...::.|...|.:.....||  .||::|.|:..:
 Worm    82 MQTGSDFVKL-----RGTNRQFRRFFSLDADLSYIRWTPTNKKPHKARIAIDEIREIRLGKNTEL 141

  Fly    78 -RPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
             |..|    ::.|    |..||...::.:|.::..:..:   .:..|.|.:|..||:.|..:..:
 Worm   142 LRSSD----EVFT----DLQEECLFSIIYGDNYETLDLI---ASSGDDANIWVTGLMALTSNKYE 195

  Fly   142 LNGSAIMF-----------LQKAHTKLCLQVDKSGRIPVKNIIK--LFAQNKEDRKRVEKALDVT 193
            ...|:..|           ..:..||      |:|.:..:...|  |...::....|:...|...
 Worm   196 CKPSSSQFATLRERWIESVFDEFDTK------KNGHLDEQTAFKAILHINSRISHHRLTNKLKEV 254

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQ--- 255
            .:.:.:.:...:.|..|.|   |||.:..|.||..|   :|..:.:..:|...|..||...|
 Worm   255 TIGAEESERGKIEKSHFVD---LYKEIGTRPEVYFL---MVRYANKDYLSCQDLRLFLETEQGMV 313

  Fly   256 ---RDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLC 317
               .|              ..:.||:||||.....:...:::|||..:|...|..:..|:...:.
 Worm   314 GVTTD--------------NCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGVFDPNHRVVT 364

  Fly   318 DDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFW-----NGRTEEPVIV 377
            .||.||.|.|||:||..:||...|| |.||.:.:...|...||.:|.|.|     :|.| ||::.
 Worm   365 MDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWDPNEADGDT-EPMVQ 427

  Fly   378 HGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDS 442
            :|.|...:|.....|..|.|.||:.|.||::|....||:...|...|.......|..|.....|.
 Worm   428 NGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAAMLIVTHLGTRLYLPKNDP 492

  Fly   443 HPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQV 507
            ...:...:.|.|...:.:|:|..||
 Worm   493 TNWDDEKNCPTPWDFQNRILIVGKK---------------------------------------- 517

  Fly   508 GLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLP 572
                                                          .|:..:...:.|.||:||.
 Worm   518 ----------------------------------------------LDNPDTDSGEVSEEDDSLA 536

  Fly   573 NTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFS-------------SFENAEKKNRCY 624
            :||           .:..|..:...|:|.||    |:.|:             |...:.:||
 Worm   537 STT-----------RRKSKRIQLCKELSDLV----PVFFNVKTLNDLLSTAPGSTTMSSRKN--- 583

  Fly   625 EMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLD 689
             ::|..|.....|:.....||....::...||:|..:|.||||..||.|||.|.|:|.||:||..
 Worm   584 -LASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCLNYQTPG 647

  Fly   690 LAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR--- 751
            |.|.|..|.|..|...||:|||:.|:.     |.|..|.........:.:.:||||.|...|
 Worm   648 LMMDLQEGKFSDNGGCGYVLKPQVMKD-----DMFVPSDRVPTSPQILHLRILSGQQLPRPRGSN 707

  Fly   752 -----ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE 811
                 |:.||.|:::|||.|...:  ||:|||::.:||.:||. |.| :|.:||||.:|....::
 Worm   708 AKGDSADPFVVVEVFGLPGDCAEE--RTRTVRNDSINPSFDES-FQF-QVSVPELALVRFLVLDD 768

  Fly   812 ---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD----------------- 856
               |...||...:|...|.|||||:.|.:..|.|:..|:||:.|.:.:
 Worm   769 DYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITNRRGGGKAKKRGMSVKRK 833

  Fly   857 --------------YVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSF 907
                          .|.|........||.....::.||...|.    ..|...||.|
 Worm   834 NSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMID----WQEECGLGPA-------- 886

  Fly   908 VFVQVGGQKKELRPVES------LATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSIS--IVAP 964
                 |..::.:|.:.|      :.:||...|:.|:|                 |.|::  .:..
 Worm   887 -----GTIRQGIRLIHSRMITLAVNSSPPPSPTTSSA-----------------ESSVTPLFIID 929

  Fly   965 SIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEK 1029
            |.:|.:....::.|...|::.|...:..::|..:..:.....:..|   :|..:..:.:.|: |.
 Worm   930 SDEHGYPAIVTMGTLPDQLQRSFNKLKNLIAHCVTTLSQSDQLLSK---IEDSIRRISECHE-EL 990

  Fly  1030 IKIAGQKSSPLEGKKPKFAITNKLVK-RLSNKSLNCLSPHSEPGVEIPACPLDLG 1083
            .|:..:  :.|:|:|...|..|.... ||....||.::...|...::.....|.|
 Worm   991 SKLCAE--AGLKGQKATRAAENFTWNLRLLKAQLNLMNKSQEEAQDVVTQVFDTG 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	29/132 (22%)
		EFh_PI-PLC21	151..305	CDD:320043	35/161 (22%)
		EF-hand motif	151..180	CDD:320043	6/30 (20%)
		EF-hand motif	187..216	CDD:320043	4/28 (14%)
		EF-hand motif	225..255	CDD:320043	8/29 (28%)
		EF-hand motif	272..305	CDD:320043	10/32 (31%)
		PI-PLCc_beta	317..702	CDD:176533	100/402 (25%)
		C2_PLC_like	736..855	CDD:175974	48/129 (37%)
		PTZ00121	<981..>1253	CDD:173412	20/104 (19%)
pll-1	NP_741068.1	PH_PLC_eta	82..191	CDD:270170	29/124 (23%)
		EFh_PRIP	210..352	CDD:320036	35/167 (21%)
		EF-hand motif	210..239	CDD:320036	6/34 (18%)
		EF-hand motif	246..279	CDD:320036	8/35 (23%)
		EF-hand motif	283..310	CDD:320036	8/29 (28%)
		EF-hand motif	319..352	CDD:320036	10/32 (31%)
		PI-PLCc_eukaryota	364..660	CDD:176501	100/402 (25%)
		C2_PLC_like	687..815	CDD:175974	48/131 (37%)