DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and plc-3

DIOPT Version :9

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_496205.2 Gene:plc-3 / 174586 WormBaseID:WBGene00004038 Length:1350 Species:Caenorhabditis elegans


Alignment Length:1367 Identity:318/1367 - (23%)
Similarity:484/1367 - (35%) Gaps:508/1367 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ALQDGEKFI------RWDDDSGTGTPVTMRVDAKGFFLYWVDQN---NELDILDIATIRDVRTGQ 74
            |::.|.|..      :||.   ....:|:...::..||..::.:   |:..||||..||:|:|..
 Worm    56 AMEKGHKVCKIAVLKKWDP---AYKQLTLDRYSRQIFLTKLELSAVRNKPTILDIRQIREVQTLN 117

  Fly    75 YA--------KRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDG 131
            |.        |..||   |:||....:..|     .:.:|..|. :::........|..:||:.|
 Worm   118 YKLNTIKVDDKWKKD---REIVNFDSKAIL-----IISYGMGFA-LSYWILLFESEDACKLWSQG 173

  Fly   132 LIKLAYSLAQLNGS-----AIMFLQKAHTKLCLQV-DKSGRIPVKNIIKLFAQNKEDRKRVEKAL 190
            |..|.......:.|     ...||.|....|.... |...|..:|..::...|.|....::::..
 Worm   174 LHNLMMDTRDRDSSPHPLRIERFLHKHFLSLMSPANDAVARKHMKPFVQTSLQFKVQSDQLQQVT 238

  Fly   191 DVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDS----IVGNSKRK--CMSIAQLVE 249
            :         |.::..:|.|..        .|...|..||.|    :....:||  .::....:.
 Worm   239 E---------DQMNSDQFSFAS--------RQLIHVPELFSSRFADLAEKHERKGLVVTFQNFLR 286

  Fly   250 FLNKTQRDPRLNEILYPYANPARAKELIQQY--EPNKFNAQKGQLSLD--GFLRYLMGDDNPIMA 310
            ||:..|.|    |:.   :|..||.|.:.:|  |...:...:.:.|:.  .|..:|...:|.:..
 Worm   287 FLDGKQFD----ELA---SNRTRALEFLNRYFQEDQAYFGDRNEPSMTVFEFCDFLFSRENSLWD 344

  Fly   311 PSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--- 372
            |:...:..||.:|:|||:|.|||||||||.||..:||::.|.|.||.||||:|||.|:|:.:   
 Worm   345 PTNEKVTHDMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIELDCWDGQKKPGS 409

  Fly   373 ----EPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGD 433
                :.||.||||...:|..:|||..|...||.|||||||||.|::|:...|..:|...::|.||
 Worm   410 AEFIDIVIYHGYTMTSKILLRDVLHVIRHYAFVTSEYPVILSIEDNCSVPAQRLLAQELKDILGD 474

  Fly   434 MLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK------------------------------- 467
            .||.:|.:    .....||.||.|::|||:|:||                               
 Worm   475 YLLTQPAN----REEKQLPSPAALKKKIIVKHKKLPIESEDLAAVVKTDEFQDTEIISRECVKKG 535

  Fly   468 ----KHHHHHHHHHH------------------------------KKPAQVGTPAA--------- 489
                |:::.|....|                              .:..:..||:.         
 Worm   536 ILMVKNNNSHEWTSHVFILFPDRLCYLIQTADPENPNDDTVSVSGDEEREEETPSGFGVKPEEMH 600

  Fly   490 ----------------------------------------------------------------- 489
                                                                             
 Worm   601 VTEEWFHGRCERDEAKKRILEHKEKGNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIIDKE 665

  Fly   490 ------NNK----------------LTTAN-----------------------SVDAKAAQQVGL 509
                  :||                ||||:                       :.|.:.|::: |
 Worm   666 KKYYFMDNKVCDTLYELVSYYTRHYLTTAHFKMVLTIPCPQPQPHLNQPWFSATADKEKAEEL-L 729

  Fly   510 SASHEDGGV---TRST--------------------------------------------ANGDV 527
            |...|||..   |.||                                            ||.:.
 Worm   730 SLVPEDGAFLIRTSSTDSSVYVLSLKVDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREF 794

  Fly   528 ATG---------------TGTGSAAGTAGHAPPLQQI-----RQSSKDSTGSSDSDSS------- 565
            ..|               |...:.|.|.|....|:.:     .::.:...|::|.:.|       
 Worm   795 VRGISLRFPVNEKDISHLTAELAEARTPGCYMDLKDLDKEVQARALRPYRGTADDELSFPANVII 859

  Fly   566 ---SEDESL-----PNTTPNLPSGN--EPPPEKA------------------------------- 589
               .::|.|     .:.|...||.:  |..|||.                               
 Worm   860 TVLRKEEGLWRGRYGSLTGWFPSAHVQEILPEKVSTSETSNYNTIELAGTLIERIHDADRPNVIR 924

  Fly   590 ------------------------------------------------QKETEAGAEISALVNYV 606
                                                            :||....||:|.||.|.
 Worm   925 ISQSNQHWMNKQYYLLAASSSEEADGWQNNLFELTRSVNTKMSILRTKEKEKRIAAELSNLVVYC 989

  Fly   607 QPIHFSSFENAEKKNRC-YEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMP 670
            |.:   .|:.|...|.. |||.||.|.:...|:::..:.|   |..:||||||.|:|..|:|:.|
 Worm   990 QAV---PFDPAHIYNDAFYEMCSFVEGKLDKLVEKGLLPF---NSRKLSRVYPNGSRITSNNYSP 1048

  Fly   671 QLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAG 735
            ...|||||.:||||:||.|..||||.|.|..|.|.||||||::|...|  .||............
 Worm  1049 VPMWNAGCHMVALNYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDD--FDPTNTEKFATAYPI 1111

  Fly   736 TVSITVLSGQFLTDKRAN-----TFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKK 795
            .:::.|:.|:.|:.|..|     .|||:::.|:|.||  |.|:|||:..||:||::: :.|.| :
 Worm  1112 RLNVQVIGGRHLSRKDKNKGICSPFVEIEIIGMPCDT--KVFQTKTIASNGLNPIWN-QTFTF-E 1172

  Fly   796 VVLPELASIRIAAYEEG-------GKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVV 853
            :..||:|.||... |:|       ...||..|.||..:..|:|.|.|:::..:.:.|:||.:.|.
 Worm  1173 IQCPEVALIRFHV-EDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSSLLVDVQ 1236

  Fly   854 VKDYVPDDL----SNFAEA--LANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQV 912
            :.......|    |:|.:|  || |:....::...|   |:..:.|..|.::..|.|        
 Worm  1237 MCSREGTQLIRSSSHFLQASRLA-PVFAHRKITNGD---SIPREMAPRLRTSATDRS-------- 1289

  Fly   913 GGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVS 977
                         ..||.:  |.|.|..:|         |.||.            |.|:|.:..
 Worm  1290 -------------LDSPTN--SESRATLLS---------GQRGS------------QDSMDSAAE 1318

  Fly   978 TS 979
            ||
 Worm  1319 TS 1320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 32/141 (23%)
PLN02222 213..850 CDD:177868 244/1013 (24%)
EF-hand_like 225..317 CDD:286375 22/101 (22%)
PI-PLCc_beta 317..702 CDD:176533 167/739 (23%)
C2_PLC_like 736..855 CDD:175974 43/130 (33%)
plc-3NP_496205.2 PH-like 74..191 CDD:302622 29/128 (23%)
EF-hand_like 278..350 CDD:286375 16/78 (21%)
PI-PLCc_gamma 351..>494 CDD:176534 69/146 (47%)
SH2_N-SH2_PLC_gamma_like 600..696 CDD:199829 6/95 (6%)
SH2_C-SH2_PLC_gamma_like 710..813 CDD:198186 13/103 (13%)
SH3 833..886 CDD:214620 8/52 (15%)
PLCYc 983..1092 CDD:128454 54/114 (47%)
C2_PLC_like 1110..1222 CDD:175974 39/116 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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