DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and Plcd4

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_006245198.1 Gene:Plcd4 / 140693 RGDID:621025 Length:830 Species:Rattus norvegicus


Alignment Length:863 Identity:268/863 - (31%)
Similarity:406/863 - (47%) Gaps:172/863 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 IATIRDVRTGQYAKRPKDNK-LRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQL 127
            |:.:..:|.||      |:: ||.:|...|   ||:....|.:|.. .|:..|   ....:.||.
  Rat    63 ISDVERIRKGQ------DSELLRYLVEEFP---LEQGFTIVFNGRR-PNLDLV---ANSVEEAQT 114

  Fly   128 WTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQ---NKEDRKRVEKA 189
            |..||..|...:|::|...             |:|:..|       :.|.|   |::.|....:|
  Rat   115 WMRGLQLLVDLVARMNYQE-------------QLDQMLR-------EWFQQADRNQDSRMSFREA 159

  Fly   190 LDVTGLPSGKVD-SISVSKFQ-----------FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCM 242
            ..:..|.:.::| ..:.|.||           .|:|...||.||:|:|:|.||::.  :|.::.:
  Rat   160 QRLLLLMNVEMDEEYAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENF--SSDKQKL 222

  Fly   243 SIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNP 307
            ::.:.|:||.:.|::...:..|        |.:||.:|||::.......||.||||.||...|..
  Rat   223 TLLEFVDFLREEQKESDHSSDL--------ALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGN 279

  Fly   308 IMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE 372
            |..|..|.:..||.||:|||:|||||||||.|.|..|:||||.|.:.|..||||||:|.|:|...
  Rat   280 IFNPDCLPIYQDMTQPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDG 344

  Fly   373 EPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLD 437
            |||:.||.|....|..||||..:|:.||::|:||:|||.:|||...||..:|::...|.|:.||.
  Rat   345 EPVVYHGRTLTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLS 409

  Fly   438 KPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAK 502
            ..|:...::   .:|.|..||.||::|.|                         ||.|...|::.
  Rat   410 TTLEEQLID---IMPSPEQLRGKILVKGK-------------------------KLRTIEVVESD 446

  Fly   503 AAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSE 567
            ..::    ...:|.|.....|:.::                 .:|...:|.:.::|:...:....
  Rat   447 KEEE----ELEKDEGSDLDPASAEL-----------------DMQSQPESQEQASGNKSKNKKKV 490

  Fly   568 DE--------------SLPNTTPNLPSGNEPPPEK---AQKETEAGAEISALVNYVQPIHFSSFE 615
            .:              ..||:.|.    :...|:|   ....|....::||||.|::...|.||.
  Rat   491 MKCPMSCLLICAHVLAQAPNSIPE----SILLPKKFLLQSSTTILCPDLSALVVYLRTAPFCSFT 551

  Fly   616 NAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQL 680
            ::::....|::|||.|.:|..|::|...|||.:|..||.||||:|.|.||||:.||..||.|||:
  Rat   552 HSKENYHIYDISSFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQM 616

  Fly   681 VALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQ 745
            ||:|.||...||.:..|:|..|..|||:|||||:|.:....:|.  ..|....|..:.:.|:|||
  Rat   617 VAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPM--KPVSLYKAQILVVQVISGQ 679

  Fly   746 FL--TDKRANT-----FVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELAS 803
            .|  .||...|     .|.|::||:|.||  |:..|..|.:||:|| |..|.|.| ::.:||||.
  Rat   680 RLPKVDKTKETTVVDPLVRVELYGVPEDT--KQQETSYVENNGINP-YWGETFYF-QIQVPELAM 740

  Fly   804 IRIAAYE----EGGKLIGHRVLP----------------VIGLCP----------GYRHVNLRSE 838
            :|....:    .....||...||                :..:.|          |||||:|.|:
  Rat   741 LRFVVKDYSRTSRNNFIGQYTLPWTCMKHGETNLRLLANIPTVAPFLIQFFCLFLGYRHVSLLSK 805

  Fly   839 VGQPIALASLFLCVVVKD 856
            .|..:..||:|:...:::
  Rat   806 DGTSLHPASIFVYTCMQE 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 23/81 (28%)
EFh_PI-PLC21 151..305 CDD:320043 44/168 (26%)
EF-hand motif 151..180 CDD:320043 5/31 (16%)
EF-hand motif 187..216 CDD:320043 8/40 (20%)
EF-hand motif 225..255 CDD:320043 8/29 (28%)
EF-hand motif 272..305 CDD:320043 14/32 (44%)
PI-PLCc_beta 317..702 CDD:176533 137/401 (34%)
C2_PLC_like 736..855 CDD:175974 47/155 (30%)
PTZ00121 <981..>1253 CDD:173412
Plcd4XP_006245198.1 PH-like 18..133 CDD:473070 23/82 (28%)
EF-hand_10 153..202 CDD:405477 11/48 (23%)
PLN02228 207..776 CDD:177873 213/637 (33%)
PI-PLCc_GDPD_SF 289..638 CDD:472694 137/401 (34%)
Blue background indicates that the domain is not in the aligned region.

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