Protein Alignment Plc21C and norpA

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_061499950.1
• Gene: norpA / 1281188
• VectorBaseID: AGAMI1_007847
• Length: 1150
• Species: Anopheles gambiae
• Alignment Length: 1350
• Identity: 479/1350 - (35%)
• Similarity: 699/1350 - (51%)
• Gaps: 296/1350 - (21%)

  Fly    14 VEVPQALQDGEKFIRW--DDDSGTGTPVTM-RVDAKGFFLYWVDQNNELDILDIATIRDVRTGQY 75
            :.||:.|..|..|.||  :.|:....|..| :||..|||:||..:..|.|::::..:.|:|.|
Mosquito    11 IPVPEPLLTGCVFDRWTEEKDNNELEPNCMFKVDEYGFFIYWKSEGREGDVIELCQVSDIRAG-- 73

  Fly    76 AKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLA 140
             ..|||.||...:.....:.:|||::|:|.|:|::|:.:.:..|.....|::|.|||.|:.:
Mosquito    74 -GMPKDMKLYNQLCNKHGENVEEKSLTICSGTDYININYQHVVCPDAATAKIWVDGLRKITH--- 134

  Fly   141 QLNGSAIMF-----LQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKV 200
              ||.|..|     |:|...:|...||..|::|||.:.:.||..|.: |.|.:.|...||||||.
Mosquito   135 --NGKANNFCPMTALKKHWMRLGFLVDPRGKVPVKVVARTFASGKTE-KLVYQILSDLGLPSGKN 196

  Fly   201 DSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILY 265
            |.|..:.|.||.||.||..:..|:::|.||.||. ..|...:::.|.:.|||:.|||||||||||
Mosquito   197 DVIEKADFTFEKFYELYHKICPRNDIEELFRSIT-QGKANAINLDQFINFLNEKQRDPRLNEILY 260

  Fly   266 PYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFIN 330
            |..:..||.|:|..||.|....:...|:.||.:||||.|:|..:...:||:..|||||:|||:||
Mosquito   261 PLYDEKRALEIITTYEQNDEAREAKTLTKDGLIRYLMSDENAPVFLDRLDIYMDMDQPLSHYYIN 325

  Fly   331 SSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLE 393
            |||||||:|.|..||||||:|||.|||||||||||.|:|:  .|||:|.||.....:|..|||:.
Mosquito   326 SSHNTYLSGRQFGGKSSVEMYRQTLLAGCRCVELDCWDGKGEDEEPIITHGMAMCTDILFKDVIY 390

  Fly   394 AIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLR 458
            |:.::||.||:|||||||||||...||.|:|.||.||.||:||.:|:..:||||...||||::|:
Mosquito   391 ALRDTAFVTSDYPVILSFENHCCKSQQYKLAKYCDEILGDLLLKEPIPDYPLEPGAVLPPPSLLK 455

  Fly   459 RKIIIKNKKKHHHHHHHHHHKKPA------------------QVGTPAANNKLTTANSVDAKAAQ 505
            |||:||||:           .||.                  :|...|:...:|....::|.||.
Mosquito   456 RKILIKNKR-----------LKPEVEKKELELFLQGEFVIEDEVKEDASAVDVTKIAELEAPAAA 509

  Fly   506 ----QVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSS 566
                .|..:|:.:|||                       ..|||:|.        |||:
Mosquito   510 AAVVPVAAAAASQDGG-----------------------EEAPPVQY--------TGST------ 537

  Fly   567 EDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDE 631
                                      |.....:|::|||.||:.|.||:.|:|||..:.||||.|
Mosquito   538 --------------------------TNVHPWLSSMVNYAQPVKFQSFDYADKKNVHHNMSSFAE 576

  Fly   632 KQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNL 696
            .....|||.:.||||||||.|:||:||.|||.||||:|||:|||||||:|:|||||.||.||||.
Mosquito   577 TTGMNLLKSQAIEFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQTSDLPMQLNQ 641

  Fly   697 GIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMY 761
            |.||||...||||||:||||:||..||||::.|||:||.:.::.|::||||:||:..|:||||||
Mosquito   642 GKFEYNGNCGYLLKPDFMRRADRSFDPFADAPVDGVIAASCAVQVIAGQFLSDKKVGTYVEVDMY 706

  Fly   762 GLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGL 826
            |||:|||||:|||:.|..||:||:|:||||:|:|||||:||.:|...|:|.|||:|.|:||:.||
Mosquito   707 GLPSDTVRKEFRTRMVPANGLNPVYNEEPFLFRKVVLPDLAVLRFGVYDENGKLLGQRILPLDGL 771

  Fly   827 CPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTD 891
            ..||||::||:|...|::|..||..:.:|.||||...:|.:||::|..:....::|       :|
Mosquito   772 QGGYRHISLRTEANFPMSLPMLFCNIELKIYVPDGFEDFMDALSDPRAFMGAAKER-------SD 829

  Fly   892 EAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGE 956
            ..:|:|            ::..|:|                               |:.:..|.|
Mosquito   830 NMKAMG------------IEETGKK-------------------------------DKEEAARKE 851

  Fly   957 DSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESL 1021
            :......|.:     .|.....|:||.:..|                 |:.|::    :|:|:::
Mosquito   852 EQRVTEPPLV-----FDPITVDSLRQEKGFQ-----------------KTAKKQ----QKELDAV 890

  Fly  1022 RKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSS 1086
            :|||.||:..:..|:::.:|          :|||                           |.|.
Mosquito   891 KKKHAKERAGVQKQQNAAIE----------RLVK---------------------------GKSK 918

  Fly  1087 EESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAE---------- 1141
            ||..|..|                   :|...:|..:|:.|:.|::.:..:...:
Mosquito   919 EEIKADPA-------------------VRKLIQEQNAQWTEMAERHKKEEWELLKQQLADQQDIL 964

  Fly  1142 -KVLKTSQTGQTKQLKASLDKVTGEV---MHQLQEARRNEVKNLATVHRDRDELIRMKREVASSV 1202
             |:::|:|..|.|||:|..::...|:   ..::......||.|..|: :.:.|..|..||...:.
Mosquito   965 RKLMETTQAAQMKQLEAKHEREIKELNSRQAKISVETSKEVANDKTL-KTKGEKDRRLREKKQNN 1028

  Fly  1203 VERGVAER--VRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLF 1265
            ::|.:.|:  ..:||  :|..::|:..||.....||....|              :|:||..::
Mosquito  1029 IKRFMDEKKTATIKQ--NREKEKLKVTHDKQLEELANDVQK--------------LSANGCRLI- 1076

  Fly  1266 HGPHHHGCTGSGSSALSGNNLTLNLDAGAAGSHSAIS-----PAKSHNSI 1310
                     .||||:.:..|:.....:|::|..:..:     |.:|.::|
Mosquito  1077 ---------SSGSSSSTSINVEQKSTSGSSGGSTTTTSAPPVPFRSFSTI 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	41/127 (32%)
		EFh_PI-PLC21	151..305	CDD:320043	66/153 (43%)
		EF-hand motif	151..180	CDD:320043	10/28 (36%)
		EF-hand motif	187..216	CDD:320043	14/28 (50%)
		EF-hand motif	225..255	CDD:320043	10/29 (34%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	183/408 (45%)
		C2_PLC_like	736..855	CDD:175974	66/118 (56%)
		PTZ00121	<981..>1253	CDD:173412	56/287 (20%)
norpA	XP_061499950.1	None