DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcz1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_006506962.1	Gene:	Plcz1 / 114875	MGIID:	2150308	Length:	689	Species:	Mus musculus

Alignment Length:	666	Identity:	209/666 - (31%)
Similarity:	325/666 - (48%)	Gaps:	101/666 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 DSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILY 265
            |..:..:...|:|..:|:.:..|.|:..:|::...|  ||.:|...|:|||.:.|.:..::.
Mouse    56 DRQNQGRITIEEFRAIYRCIVHREEITEIFNTYTEN--RKILSENSLIEFLTQEQYEMEIDH--- 115

  Fly   266 PYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFIN 330
                 :.:.|:|.:|||.:....:.|:|::||.||:...:..:...:...:..||:.|:|.|||:
Mouse   116 -----SDSVEIINKYEPIEEVKGERQMSIEGFARYMFSSECLLFKENCKTVYQDMNHPLSDYFIS 175

  Fly   331 SSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAI 395
            |||||||...|:.|.|.:..|...|:.||||:|:|.|:|...||::.|||||..::..|.|::||
Mouse   176 SSHNTYLISDQILGPSDIWGYVSALVKGCRCLEIDCWDGSQNEPIVYHGYTFTSKLLFKTVVQAI 240

  Fly   396 AESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRK 460
            .:.||.||:|||:||.||||:|.||..:|:..:..|||.||...|:..|    ..||.|..|:.|
Mouse   241 NKYAFVTSDYPVVLSLENHCSPGQQEVMASILQSTFGDFLLSDMLEEFP----DTLPSPEALKFK 301

  Fly   461 IIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANG 525
            |::||:|                |||                      ||.:||..|..:|
Mouse   302 ILVKNRK----------------VGT----------------------LSETHERIGTDKS---- 324

  Fly   526 DVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDS--------SSEDESLPNTTPNLPSGN 582
                           |.....:::.....|.....|.::        ..|.|:.|:|...:..
Mouse   325 ---------------GQVLEWKEVIYEDGDEDSGMDPETWDVFLSRIKEEREADPSTLSGIAG-- 372

  Fly   583 EPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVN 647
               .:|.:::.:....:|.||.|.:...|.:|:.:....:..|.:|..|.:|..|.|.|..||:.
Mouse   373 ---VKKRKRKMKIAMALSDLVIYTKAEKFRNFQYSRVYQQFNETNSIGESRARKLSKLRVHEFIF 434

  Fly   648 YNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPE 712
            :....::||||...|.|||||.||.|||.|||:|||||||..|.|.|..|.|..|..|||:|||:
Mouse   435 HTAAFITRVYPKMMRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPD 499

  Fly   713 FMRRSDRRLDPFAESTVDGIIAGTVSITVLSG-QFLTDKRANT---FVEVDMYGLPADTVRKKFR 773
            .:|.:....:|......|..:  |::|.::|| |......:||   .|.:::||:|.|.|::  :
Mouse   500 ILRDTTLGFNPNEPEYDDHPV--TLTIRIISGIQLPVSSSSNTPDIVVIIEVYGVPNDHVKQ--Q 560

  Fly   774 TKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE-----GGKLIGHRVLPVIGLCPGYRHV 833
            |:.|::|..:|.:: |.|.| .:.:||||.||.....:     |.:|:|...|||  ||......
Mouse   561 TRVVKNNAFSPKWN-ETFTF-LIQVPELALIRFVVETQQGLLSGNELLGQYTLPV--LCMNKVGN 621

  Fly   834 NLRSEVGQPIALASLF 849
            :.|.....|...|:||
Mouse   622 HERMHTADPRVHATLF 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167
		PLN02222	213..850	CDD:177868	207/654 (32%)
		EF-hand_like	225..317	CDD:286375	22/91 (24%)
		PI-PLCc_beta	317..702	CDD:176533	133/392 (34%)
		C2_PLC_like	736..855	CDD:175974	39/123 (32%)
Plcz1	XP_006506962.1	EF-hand_7	21..73	CDD:372618	3/16 (19%)
		PLN02952	79..614	CDD:178538	197/618 (32%)
		PI-PLCc_GDPD_SF	162..489	CDD:387364	133/392 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750