DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and Plce1

DIOPT Version :9

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_446210.1 Gene:Plce1 / 114633 RGDID:69424 Length:2281 Species:Rattus norvegicus


Alignment Length:1239 Identity:307/1239 - (24%)
Similarity:481/1239 - (38%) Gaps:343/1239 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 NMTFVNF--------CCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRI 167
            ||:|:.|        ..:|:|:..::.      .||: ..|.|| ......:|.|.::.:.:...
  Rat  1193 NMSFIEFVELFKSFSIRSRKDLKDIFD------IYSV-PCNRSA-SESTPLYTNLTIEENTNDLQ 1249

  Fly   168 PVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDS 232
            |   .:.|..:|..|          .||.......:|.::.|..|.......:|..:.:|.....
  Rat  1250 P---DLDLLTRNVSD----------LGLFMKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLG 1301

  Fly   233 IVGNSKRKCMSIAQLVEFLNKTQRDP-RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDG 296
            |.|      :.|.||.:||...|.:. ..:|||          .:||::|||.....:|.||.:|
  Rat  1302 IFG------VGILQLNDFLVNCQGEHCTYDEIL----------SIIQKFEPNISMCHQGLLSFEG 1350

  Fly   297 FLRYLMGDDNPIMAPSKLDLC----DDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLA 357
            |.|:||..||   ..||.|..    .|:..|:|:|:|.||||||||||||.|:||||:|.|.||.
  Rat  1351 FARFLMDKDN---FASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQ 1412

  Fly   358 GCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAK 422
            |||.:|||.|:|....|:|.||:|...:|..|:|:|||..|||.||:.|:|:|.||||:..||.|
  Rat  1413 GCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRK 1477

  Fly   423 IANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTP 487
            :|...:.:||:.|:.|.|.......:..||.|..||||:::||||...|.               
  Rat  1478 MAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQ--------------- 1527

  Fly   488 AANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQS 552
                  |..:.:..||.|...:......||    .||                  .||.....:.
  Rat  1528 ------TPVDILKQKAHQLASMQTQAFTGG----NAN------------------PPPASNEEEE 1564

  Fly   553 SKDSTGSSDSDSSSEDESLPNTTPN--------------LP---------SGNEPP--------- 585
            .::.....|.:|.|:|..|.:...|              :|         |||:..         
  Rat  1565 DEEDEYDYDYESLSDDNILEDRPENKSCADKLQFEYNEEVPKRIKKADNSSGNKGKVYDMELGEE 1629

  Fly   586 ---PEKAQKETEAGAEISALVNYVQPIHF---------SSFENAEKKNR---------------- 622
               |:..::..:...|:|.||.|.|.:.|         .|....|:|:|                
  Rat  1630 FYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSGRGKERKSRKSIFGNNPGRMSPGET 1694

  Fly   623 --------------------------------------CYEMSSFDEKQATTLLKERPIEFVNYN 649
                                                  ||.:||.:|..|..|.:....:.:.:.
  Rat  1695 ASFNRTSGKSSCEGIRQIWEEPPLSPNTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHT 1759

  Fly   650 KHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFM 714
            ..||.|.|||.||.||||..|.:||..|.||||||:||.||.:.||..:||.|...||:|||..:
  Rat  1760 ACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVL 1824

  Fly   715 RRSD----RRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKRANTFVEVDMYGLPADTVRKKFR 773
            ....    ::..|. |..:|.:...|.|:|::|||.:  ::...:..:|||:.|:|.|:..  ||
  Rat  1825 WDKSCPMYQKFSPL-ERDLDAMDPATYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDSCH--FR 1886

  Fly   774 TKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLI-GHRVLPVIGLCPGYRHVNLRS 837
            ||.:..|.:||:::|: |:| :|...:|..:|.|..|.....| ..|::|:..|..||||:.||:
  Rat  1887 TKPIHRNTLNPMWNEQ-FLF-RVHFEDLVFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQLRN 1949

  Fly   838 EVGQPIALASLFLCVVVKDYVPDDLSNFAEALAN-------------------PIKY------QS 877
            ...:.:.::|||:.....:..|...:..|..:.|                   |..:      :.
  Rat  1950 LHNEILEISSLFINSRRMEDNPSGSTRPASLMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEG 2014

  Fly   878 ELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELR--PVESLATSPKHRPSISAAAA 940
            ...|:.:|..:..|:...|.:||..|.:...|  :..:|.|.|  |.:. |..|:          
  Rat  2015 TKAKQLLQQILAVDQDTKLTAADYFLMEEKHF--ISKEKNECRKQPFQR-AVGPE---------- 2066

  Fly   941 MSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFD----VDLVLAEPLEKI 1001
                           ||                      |.|:.:|.|.    |..::.:|.::.
  Rat  2067 ---------------ED----------------------IVQILNSWFPEEGYVGRIVLKPQQET 2094

  Fly  1002 LDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKS---------SPLEG----KKPKFAITNKL 1053
            |:.|::                .||..::.::.::.         ||.:.    |.|:.:....:
  Rat  2095 LEEKNI----------------VHDDREVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDV 2143

  Fly  1054 VKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSAC 1118
            :::...|:....|..:.|.      |.|.      ....:..:|.....||....:|...|...|
  Rat  2144 IQQTLCKAKYSYSILNNPN------PCDY------VLLEEVMKDAPNKKSSTPKSSQRILLDQEC 2196

  Fly  1119 ---------------REYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMH 1168
                           .:...|.:..:|.....|..|:|....|..|.||:.|.:....|..|.:.
  Rat  2197 VFQAQSKWKGAGKFILKLKEQVQASREDKRRGISFASELKKLTKSTKQTRGLTSPPQLVASESVQ 2261

  Fly  1169 QLQE 1172
            ..:|
  Rat  2262 SKEE 2265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 9/41 (22%)
PLN02222 213..850 CDD:177868 226/746 (30%)
EF-hand_like 225..317 CDD:286375 30/92 (33%)
PI-PLCc_beta 317..702 CDD:176533 147/486 (30%)
C2_PLC_like 736..855 CDD:175974 40/121 (33%)
Plce1NP_446210.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
GRF CDC25 domain 529..740
RasGEF 531..710 CDD:279011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1050..1146
PLN02952 1299..1962 CDD:178538 224/729 (31%)
EF-hand_like <1309..1360 CDD:286375 21/60 (35%)
PI-PLCc_epsilon 1372..1812 CDD:176538 147/482 (30%)
PIPLC X domain 1373..1521 74/147 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1547..1572 6/46 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1664..1703 4/38 (11%)
PIPLC Y domain 1734..1824 42/89 (47%)
C2 domain 1839..1923 29/87 (33%)
C2_PLC_like 1847..1963 CDD:175974 40/119 (34%)
RA1 domain 1989..2093 23/153 (15%)
RA2 domain 2114..2217 15/114 (13%)
PLC_epsilon_RA 2116..2215 CDD:176375 15/110 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2239..2281 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345370
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.750

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