DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCD3

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_024306322.1	Gene:	PLCD3 / 113026	HGNCID:	9061	Length:	834	Species:	Homo sapiens

Alignment Length:	819	Identity:	237/819 - (28%)
Similarity:	348/819 - (42%)	Gaps:	234/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 AQLWTDGLIKLAYSL------AQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKED- 182
            ||.|..||.||...|      .:|:.....:|.:|.:.   |..|.....:|:::::...:..|
Human   160 AQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSN---QDSKMSFKEIKSLLRMVNVDMNDM 221

  Fly   183 -------------RKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIV 234
                         ..|:|.|                   :.|:|   .:.|.:|.|:|.:|....
Human   222 YAYLLFKECDHSNNDRLEGA-------------------EIEEF---LRRLLKRPELEEIFHQYS 264

  Fly   235 GNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLR 299
            |..  :.:|..:|:|||.....:.         |..|||::|||.||.|:...|...::||||:.
Human   265 GED--RVLSAPELLEFLEDQGEEG---------ATLARAQQLIQTYELNETAKQHELMTLDGFMM 318

  Fly   300 YLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVEL 364
            ||:..:...:..:...:..||:||::||||:||||||||..|:.|.||.|.|.:....|||||||
Human   319 YLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVEL 383

  Fly   365 DFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCRE 429
            |.|.|...||||.||:|...:|..:||::|:.:.||..|.||||||.||||...|||.:|.:...
Human   384 DCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCT 448

  Fly   430 IFGDMLLDKPLDSHPLEPN-MDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKL 493
            |.||||:.:.|||    || .:||.|..|:.::::|.||                  .|||.
Human   449 ILGDMLVTQALDS----PNPEELPSPEQLKGRVLVKGKK------------------LPAAR--- 488

  Fly   494 TTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTG 558
                                                                       |:|...
Human   489 -----------------------------------------------------------SEDGRA 494

  Fly   559 SSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGA----------EISALVNYVQPIHFSS 613
            .||.:...||:                 |:.::|.||.|          |:|||..|.......:
Human   495 LSDREEEEEDD-----------------EEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRT 542

  Fly   614 FENAEKKNRCYEMSSFDEKQATTLLKE-------------------------RP----------- 642
            ...|....:..::||..|::|..|::|                         ||
Human   543 LHPAPNAPQPCQVSSLSERKAKKLIREAGQKRVRSGGRVTWGRAWALFPGGYRPGLWVRDPRSLS 607

  Fly   643 ---------IEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGI 698
                     ..||.:|..||:||||.|.|.:|:|:.||..||:|||||||||||....|.||.|.
Human   608 RSHPNSAPGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGR 672

  Fly   699 FEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRA-------NTFV 756
            |..|.:.||:|||..:|:.|...||    ...|....|:||.||:.|.|....|       :..|
Human   673 FLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLV 733

  Fly   757 EVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEE-PFVFKKVVLPELASIRIAAYE----EGGKLI 816
            .::::|:|||..|::  |..|.:||.||.:.:. .|..:   .||||.:|....:    .....:
Human   734 RIEIHGVPADCARQE--TDYVLNNGFNPRWGQTLQFQLR---APELALVRFVVEDYDATSPNDFV 793

  Fly   817 GHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVK 855
            |...||:..|..||||::|.|:.|..::.|:||:.:.::
Human   794 GQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	9/25 (36%)
		PLN02222	213..850	CDD:177868	217/704 (31%)
		EF-hand_like	225..317	CDD:286375	26/91 (29%)
		PI-PLCc_beta	317..702	CDD:176533	138/440 (31%)
		C2_PLC_like	736..855	CDD:175974	40/130 (31%)
PLCD3	XP_024306322.1	PH_PLC_delta	65..181	CDD:270169	8/20 (40%)
		EFh_PI-PLCdelta3	186..324	CDD:320048	39/173 (23%)
		EF-hand motif	186..215	CDD:320048	5/31 (16%)
		EF-hand motif	222..251	CDD:320048	5/50 (10%)
		EF-hand motif	255..287	CDD:320048	9/42 (21%)
		EF-hand motif	291..324	CDD:320048	15/32 (47%)
		PI-PLCc_delta3	336..676	CDD:176567	138/440 (31%)
		C2_PLC_like	705..832	CDD:175974	40/131 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750