DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plcg2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_017949009.1	Gene:	plcg2 / 100496686	XenbaseID:	XB-GENE-952431	Length:	1260	Species:	Xenopus tropicalis

Alignment Length:	1224	Identity:	285/1224 - (23%)
Similarity:	437/1224 - (35%)	Gaps:	457/1224 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 WVDQNNELD-ILDIATIRDVRTGQYAK---RPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNM 112
            |...|:::: .||:..|:::|.|:.:|   |.|.::.:           |:...|:.:|:.|| :
Frog    56 WCKTNDKIEGFLDLMEIKEIRPGKNSKDFQRGKCDRCK-----------EDVCFTIFYGNQFV-L 108

  Fly   113 TFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPV-----KNI 172
            ..::......|.|:.|..||..|...:|..:..||  ::....|....||::.:..:     |.|
Frog   109 NTLSLAADSVDDAEKWKCGLTILLEEVASASTPAI--IESWLRKQIYSVDQTRKNSISFRELKTI 171

  Fly   173 IKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK--FQFEDFYNLYKYLTQRSEVERLFDS--- 232
            :.. |..|.:..||.|         .|:..|.:.:  ..||.|:..||.|....: :.:.|.
Frog   172 LSQ-ANFKANSMRVLK---------DKLTEIGIQRDDISFEHFHVFYKKLMFEQQ-KMILDEFRK 225

  Fly   233 -----IVGNSKRKCMSIAQLVEF----LNKTQRDP-----RLNEILYPYANPARAKELIQQYEPN 283
                 |:||..|...|...|.:|    :::.|..|     ::.|.:..:.:..    :.:..||.
Frog   226 DSSVFILGNVDRPDGSAVHLHDFQRFLVHEQQESPAQDLSKVRERMTKFVDDT----MRETAEPF 286

  Fly   284 KFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDL--CDDMDQPMSHYFINSSHNTYLTGHQLTGKS 346
            .|        :|.||.||...:|.|. ..|.|.  ..:|:.|:|||:|.|||||||||.||..:|
Frog   287 LF--------VDEFLTYLFSKENSIW-DEKYDTISVQNMNNPLSHYWIASSHNTYLTGDQLRSES 342

  Fly   347 SVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSF 411
            |.|.|.:||..||||:|||.|:|...:|:|.||:|...:|...||::||.:.||.|||||||||.
Frog   343 STEAYVRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFATSEYPVILSI 407

  Fly   412 ENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD-LPPPAMLRRKIIIKNKK---KHHHH 472
            |.||...||..:|...:|:.|::||.|     |:|...| ||.|..|:.:||||:||   |:...
Frog   408 EEHCCVEQQRHMAKVFKEVLGELLLTK-----PIEATADQLPSPTQLKGRIIIKHKKLETKNPGT 467

  Fly   473 HHHHHHKKPAQVG----------------TPAANNKLTTANSVD--------------------- 500
            :..:|.::....|                ...|.:||:..:.::
Frog   468 NTENHKEEQNLQGELYMWDGIDQKWSSRYCAIAGDKLSYGDEIEQTEDSAAPKRTIDLHLQEKWF 532

  Fly   501 -----------AKAAQQ-------------VGLSASHED---------GGV----TRSTANGDV- 527
                       .|..|:             |..|.|:.|         |.|    .||..:|::
Frog   533 HGRMYNGRFMAEKLLQEYCAEVGGKDGTFLVRQSESYRDDYTLSFWRSGRVQHCRIRSCTDGEII 597

  Fly   528 ------------------------------------------------------ATGTG------ 532
                                                                  :.|..
Frog   598 KYFLTDNLMFDSIYDLIQHYKEYSLRCAEFELRLTDAVPQPNPHLSKDWYYDNLSRGEAEDMLMR 662

  Fly   533 --------------------TGSAAGTAGHA---------------------------------- 543
                                |..|.|...|.
Frog   663 IPRDGAFLIRRREEQDSYAITFRAEGKVKHCRIQRDGRMFVLGTSAYFENLVELVSYYQKHPLYR 727

  Fly   544 ------PPLQQIRQ---SSKDSTGSSD-------------------------------SDSSS-- 566
                  |..:::.|   :.||.:...|                               ||..|
Frog   728 KMKLRYPVTEELLQRYSTEKDLSAIYDVKNKLYVNPEEISPAMPQGTVKALYNYTAVRSDELSFC 792

  Fly   567 ---------------------------------EDES----------LPNTTP------------ 576
                                             ||.|          |...:|
Frog   793 TGALIHNVSRVSEGWWKGDYGDKIQYFFPSNYVEDISMNASEIIANQLIEDSPLGSMCRGILEMG 857

  Fly   577 ------------------NLPSGNEPPP-------------------------------EKA--Q 590
                              :|.|.|...|                               ||.  :
Frog   858 SYNIRKLLNGKYNKQFVLSLESKNPEEPTVDFAADTIEEFFVWYKHIQQIEQKKGAEDFEKGTLE 922

  Fly   591 KETEAGAEISALVNYVQPIHFSSFENAEKKNRC-----YEMSSFDEKQATTLLKERPIEFVNYNK 650
            |:.|...|:|.||.|.:|       .:|.|.:.     .|:.||.|.:..::.:::.||.:.||:
Frog   923 KQQEIARELSDLVMYCKP-------KSEAKEKLESPDFREIRSFAENKGESIARQKSIELLRYNR 980

  Fly   651 HQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMR 715
            ...:|:||..:|.||||:.|...|..|.|::|||:||.|..||:|..:|.||...||:|:||.||
Frog   981 KAFTRIYPKSSRVDSSNYDPLPLWLCGDQMIALNYQTPDRYMQINNAMFAYNGECGYILQPECMR 1045

  Fly   716 RSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR---ANTFVEVDMYGLPADTVRKKFRTKTV 777
              :...||   |.....:...|:|.||..:.|....   |..||||::.|...|  ..||||..:
Frog  1046 --EESYDP---SDSRRQLQMIVTIKVLGARHLPKPGRGIACPFVEVEVCGGEYD--NNKFRTIVM 1103

  Fly   778 RDNGMNPLY----DEEPFVFKKVVLPELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVN 834
            .|||:||::    .:..|   ::..||:|.:|...|||    ....:....:||..|..|||.|.
Frog  1104 NDNGLNPVWSGSSQQAEF---EIHEPEIAFLRFVVYEEDMFSDPNFLAQCTIPVKCLKTGYRSVP 1165

  Fly   835 LRSEVGQPIALASLFL-CVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLS 887
            |::...:.:.||||.: |.:.|     ||....|..::    ..:|.||...|:
Frog  1166 LKNGYSENLELASLLVYCQIQK-----DLEKVEELYSS----SKQLRKRQTDLT 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	22/96 (23%)
		PLN02222	213..850	CDD:177868	238/1012 (24%)
		EF-hand_like	225..317	CDD:286375	23/110 (21%)
		PI-PLCc_beta	317..702	CDD:176533	158/730 (22%)
		C2_PLC_like	736..855	CDD:175974	42/130 (32%)
plcg2	XP_017949009.1	PH_PLC_gamma	24..141	CDD:270168	22/96 (23%)
		EFh_PI-PLCgamma2	147..300	CDD:320045	37/175 (21%)
		PI-PLCc_gamma	313..>460	CDD:176534	76/151 (50%)
		PH-like	479..>511	CDD:388408	4/31 (13%)
		SH2_N-SH2_PLC_gamma_like	526..627	CDD:199829	11/100 (11%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	7/102 (7%)
		SH3_PLCgamma2	774..828	CDD:212902	4/53 (8%)
		PH-like	<841..910	CDD:388408	5/68 (7%)
		PI-PLCc_GDPD_SF	<917..1032	CDD:387364	42/121 (35%)
		C2_PLC_like	1060..1186	CDD:175974	42/130 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010