DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and LOC100496658

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_017950677.1 Gene:LOC100496658 / 100496658 XenbaseID:XB-GENE-29083287 Length:1301 Species:Xenopus tropicalis


Alignment Length:1289 Identity:295/1289 - (22%)
Similarity:450/1289 - (34%) Gaps:485/1289 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 TGTPVT----------------MRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNK 83
            |||.:|                :|:|.:....:...:..|.|| |:..|:::|.|   |..:|.:
 Frog    32 TGTVLTLFYQKKSQRPERRTFQLRMDTRQVVWFRTTEKVEGDI-DVREIKEIRPG---KNSRDFE 92

  Fly    84 LRQIVTLGPQDTLEEKTVTVC----HGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNG 144
            ..      |:|| .:...|:|    :|:|| .:..|:......:...||..||..:.....:..|
 Frog    93 RY------PEDT-RKLDATLCFIILYGTDF-RLKTVSAAAFSEEEVNLWISGLNWVVADTLKAPG 149

  Fly   145 SAIMFLQKAHTKLCLQVDKS--GRIPVKNIIKLFAQNKEDRKRV-------EKALDVTGLPSGKV 200
            .  :.:::...|....||::  |.:.||::..|..|   ...||       :|.|:        :
 Frog   150 P--LQIERWLGKQFNAVDRAREGSVTVKDLKALLPQ---VNYRVPNMRFLRDKMLE--------I 201

  Fly   201 DSISVSKF-QFEDFYNLYKYLTQRSEVERLFDSI-VGNSKRKCM---SIAQLVEFLNKTQRDPRL 260
            ::.|...| .|..|||...:..|:|.:|:|..|. :.|..|..:   |:.....||...|::...
 Frog   202 EARSELTFPHFVLFYNNLMFDAQKSIIEQLELSFPLRNVDRPSLCQISLYDFQRFLQFDQKEAWA 266

  Fly   261 NEILYPYANPARAKELIQQYEPNKFNAQKGQ-----LSLDGFLRYLMGDDNPIMAPSKLD--LCD 318
            .:|     |..|.      |..|......|.     |.||.||.||...:|.|| .|:.:  :.:
 Frog   267 GDI-----NKVRG------YLCNYLKDSDGDVCEPILQLDEFLTYLFSKENMIM-DSRFEQVVPE 319

  Fly   319 DMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFV 383
            :|..|:|.|:|:|||||||||.|.:.:||:|.|.:||..||||:|||.|:|..:.|:|.||:|..
 Frog   320 EMTYPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDDLPIIYHGHTLT 384

  Fly   384 PEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPN 448
            .:|...|||..|.::||.|||||||||.|:||:..||..:|:|.|::||||||.||:|.:..|  
 Frog   385 SKIKFLDVLHTIKDNAFVTSEYPVILSIEDHCSVVQQRNMAHYFRKVFGDMLLTKPVDINADE-- 447

  Fly   449 MDLPPPAMLRRKIIIKNKK---------------------------------------------- 467
              ||.||.|::||:||:||                                              
 Frog   448 --LPSPAQLKKKILIKHKKLVEGNLYEEVSTASYSENDISNSIKNGILYLEDPIDHTWSPHYFVL 510

  Fly   468 ----------------------------------------------------------------- 467
                                                                             
 Frog   511 TSNKIYYSEETSRYQSNDEDEEMEPKEEFNNNELHFSEKWFHGKLGGGRDGRQIAEKLLHEYCTE 575

  Fly   468 ------------------------------KHHHHHHH------------------------HHH 478
                                          :|...|..                        |:.
 Frog   576 TGGKDGTFLVRESETFVGDYTLSFWRSSRVQHCRIHSRQEAGSTKFYLTDNLVFDSLYGLISHYR 640

  Fly   479 KKPAQ-----------VGTPAAN------------------------------------------ 490
            :.|.:           |..|.|:                                          
 Frog   641 EVPLRCNEFEMRLTDPVPQPNAHESKEWYHANLTRLQAEHMLMRVPRDGAFLLRKRSETSSFAIS 705

  Fly   491 ----------------------------------------------------------------- 490
                                                                             
 Frog   706 FRAEGKIKHCRIQQEGRLFMLGSSAEFESLVDLISYYEKHPLYRKMRLRYPINEEALEKMGTAEL 770

  Fly   491 -----------------NKLTTANSV-----DAKAAQQVGL---------SASHEDGGVTRSTAN 524
                             ||:.|:...     |.||.::..|         :...:|||..|....
 Frog   771 DYDALFEGRTPHVYVEANKMPTSRCTVKALYDYKAQREDELTFCKQAIIHNVDKQDGGWWRGDYG 835

  Fly   525 G----------------------------------------------DVATGTGTGSAAGTAG-- 541
            |                                              ||.:.....|..|.:.  
 Frog   836 GKKQLWFPANYVEETTSAMSPDQDEGSFYFGQSVENSPLGNFLKGFIDVPSCHIVSSKDGRSSRP 900

  Fly   542 -----HAPPLQQIRQSSKDSTGSSDSDSSSED------ESLPNTTPNLPSGNEPPPEKAQKETEA 595
                 |:   ||:...|:....::|:.....|      |:..|....:..|     :..::..:.
 Frog   901 YVFTIHS---QQMSHPSQSLDVAADTQEELNDWIGKIREATQNADARMQEG-----KIMERRKKI 957

  Fly   596 GAEISALVNYVQPIHFSSFENAEKKNRCY-EMSSFDEKQATTLL-KERPIEFVNYNKHQLSRVYP 658
            ..|:|.||.|.:|:.|.. |....:..|| :||||.|.:|.... :.:..:|:.||:.|||||||
 Frog   958 ALELSELVVYCRPVPFDE-EKIGTEKACYRDMSSFPETKAEKYANRSKGKKFLQYNRRQLSRVYP 1021

  Fly   659 AGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDP 723
            .|.|.||||:.|...|..|.|||||||||.|..||||..:|....:|||:|:|:.||  |...||
 Frog  1022 KGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQLNQALFMLGGQSGYVLQPDIMR--DDLFDP 1084

  Fly   724 FAESTVDGIIAGTVSITVLSGQFLTDKRAN---TFVEVDMYGLPADTVRKKFRTKTVRDNGMNPL 785
            |.::::..:...||.:.:|..:.|.....:   .|:||::.|...|  ..|.::..|.|||:||:
 Frog  1085 FDKNSLKIVEPITVQLQILGARHLPKNGRSIVCPFIEVEVCGSEFD--NSKSKSDVVADNGLNPV 1147

  Fly   786 YDEEPFVFKKVVLPELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALA 846
            :..:.||| .:..||.|.:|...|||    ....:......|.||..|||.|.||:...:.:.||
 Frog  1148 WMMKQFVF-DITNPEFAFLRFVVYEEDMFSDPNFLAQATFSVKGLKTGYRSVPLRNSYSEELELA 1211

  Fly   847 SLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSAD 900
            ||.:.:.:.:...:|..|...::       .:|..|..:||......|...:.|
 Frog  1212 SLLVHIEIVNAKEEDDENLYTSI-------QQLRDRASELSSQVSSYERANNCD 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 28/129 (22%)
EFh_PI-PLC21 151..305 CDD:320043 42/172 (24%)
EF-hand motif 151..180 CDD:320043 8/30 (27%)
EF-hand motif 187..216 CDD:320043 7/29 (24%)
EF-hand motif 225..255 CDD:320043 8/33 (24%)
EF-hand motif 272..305 CDD:320043 11/37 (30%)
PI-PLCc_beta 317..702 CDD:176533 162/759 (21%)
C2_PLC_like 736..855 CDD:175974 39/125 (31%)
PTZ00121 <981..>1253 CDD:173412
LOC100496658XP_017950677.1 PH_PLC_gamma 30..151 CDD:270168 29/132 (22%)
EFh_PI-PLCgamma1_like 156..305 CDD:320046 42/170 (25%)
EF-hand motif 156..185 CDD:320046 8/31 (26%)
EF-hand motif 193..220 CDD:320046 8/34 (24%)
EF-hand motif 226..261 CDD:320046 9/34 (26%)
EF-hand motif 271..305 CDD:320046 11/39 (28%)
PI-PLCc_gamma 318..>453 CDD:176534 72/138 (52%)
PH-like 487..>523 CDD:473070 0/35 (0%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 4/103 (4%)
SH2_C-SH2_PLC_gamma_like 663..766 CDD:198186 0/102 (0%)
SH3_PLCgamma 796..849 CDD:212759 9/52 (17%)
PH-like <860..941 CDD:473070 11/83 (13%)
PLCYc 962..1077 CDD:128454 54/115 (47%)
C2_PLC_like 1095..1219 CDD:175974 39/126 (31%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.