DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plcl1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_012826838.2 Gene:plcl1 / 100495595 XenbaseID:XB-GENE-6468167 Length:1059 Species:Xenopus tropicalis


Alignment Length:1180 Identity:297/1180 - (25%)
Similarity:483/1180 - (40%) Gaps:323/1180 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQ 126
            |||:.|:::|.|:..:..::|.|...:       .|:..:::.||.::.::..|   ....|:|.
 Frog   122 LDISAIKEIRLGKNTETFRNNGLADQI-------CEDSALSIIHGENYESLDLV---ANSADVAN 176

  Fly   127 LWTDGL-------------------------IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGR 166
            :|..||                         :...:..|.::|:.|| |:....:|..|::    
 Frog   177 IWVSGLRYLVSHSKQPLDSVEGGQNTPRLQWLNSVFEAADVDGNGIM-LEDTAVELIKQLN---- 236

  Fly   167 IPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFD 231
             |.....|:..:.||.:|..||.            :..|:|   |:||..:..|..|.||..|..
 Frog   237 -PAIKEAKVRLKFKEIQKSKEKL------------TTRVTK---EEFYEAFCELCTRPEVYFLLV 285

  Fly   232 SIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDG 296
            .|..|  ::.:....|:.||...|...::.|.:        ..::||:||.::....||.|::||
 Frog   286 QISKN--KEYLDANDLMLFLESEQGMTQVTEEM--------CLDIIQKYELSQEGCLKGFLTIDG 340

  Fly   297 FLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRC 361
            |.:||:..:..:..|....:|.||.||:|||:|||||||||...|..|.:.:..|.:.|...||.
 Frog   341 FTQYLVSHECDVFDPVHKKVCQDMAQPLSHYYINSSHNTYLIEDQFRGPADINGYVRALKLSCRS 405

  Fly   362 VELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANY 426
            :|||..:|...||:|.:..:....:..::|:|.|.:.||.:||:|:||...|||:.:||..:..:
 Frog   406 IELDVSDGPDNEPIICNRNSMTSSLAFRNVIEVINKYAFISSEFPLILCIGNHCSVQQQKVMVQH 470

  Fly   427 CREIFGDMLL-DKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAAN 490
            .::|||..|. ::||   |||..  ||.|..|::|||:|.||                       
 Frog   471 IKKIFGSKLFTERPL---PLESY--LPSPEKLKKKIIVKGKK----------------------- 507

  Fly   491 NKLTTANSVDAKAAQQVGLSASHE--DGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSS 553
                              |.:.::  :|.||......:::                     |:.|
 Frog   508 ------------------LPSDYDLLEGEVTDEDEEAEMS---------------------RRMS 533

  Fly   554 KDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAE 618
            :|..|.                              |:......|:|.||:..:.:.:..|:...
 Frog   534 EDYFGE------------------------------QRLITLCKELSDLVSICKSVQYRDFDVTM 568

  Fly   619 KKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVAL 683
            |.....|:.||.|.||:.:..|.|.:||||||..||||||:..|.||||..||.|||.|||:||:
 Frog   569 KSQNYGEICSFSESQASRIANEYPEDFVNYNKKFLSRVYPSPMRIDSSNLNPQDFWNCGCQIVAM 633

  Fly   684 NFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQ-FL 747
            |:||....|.||:..|..|...||:|:|..||..........:..|.|:....:.|.::||| |.
 Frog   634 NYQTPGPMMDLNIAWFMQNGGCGYVLRPSIMRDEISYFSANTKGMVPGVSPQVLHIKIISGQNFP 698

  Fly   748 TDKRA-------NTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIR 805
            ..|.|       :.::.::::|:|||...:  |||||:.||.||::||. |.| ::.|||||.:|
 Frog   699 KPKGACAKGDVIDPYICIEIHGIPADCAEQ--RTKTVQQNGDNPIFDES-FEF-QINLPELAMVR 759

  Fly   806 IAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVV------------- 854
            ....::   |.:.||...:||..|.||||||.|||.||..:..|.||:.|.:             
 Frog   760 FMVLDDDYIGDEFIGQYTIPVDCLQPGYRHVPLRSFVGDTLEHAKLFVHVAITNRGGGGKAQKKG 824

  Fly   855 ---------KDY---------VPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADE 901
                     ::|         ..||:...|   .:|::..|::.                    |
 Frog   825 LSARIGKKAREYTMLRNTGLKTVDDIFKLA---IHPLREASDVR--------------------E 866

  Fly   902 DLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSI 966
            ::..:.|         .|:.:..:.||...:..|.:.|...|:           .||..:|..::
 Frog   867 NMQNALV---------SLKELCGVPTSASLKQCILSLATRLVN-----------SDSTPLVFLNM 911

  Fly   967 QHQHSLDQSVSTSIRQVESSQFDV-DLVLAEPLEKILDHKSVKEKRLEMEKK----LESLRKKHD 1026
            :..:...:.|. :|..|:...... :|::.|.........::.:|.|:.:|.    .|.|.....
 Frog   912 KDNYPYLEPVG-AIPDVQKKLLTAYELMIQESRTLFESADTIHDKILQCQKTGMEFHEELHSLGT 975

  Fly  1027 KEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAA 1091
            ||.||          |:|             .||::                             
 Frog   976 KEGIK----------GRK-------------LNKAI----------------------------- 988

  Fly  1092 ADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQ-L 1155
                |..|...:.|.|  |...|::|..|.|...:::|:   ..:.|...|...|:...::|: |
 Frog   989 ----ESFAWNVTVLKG--QGDLLKNAKNEATENMKQIQQ---ACVSSGLGKASSTTADAKSKRGL 1044

  Fly  1156 KASLDKVTGE 1165
            .|..:|.|||
 Frog  1045 AAIEEKDTGE 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 18/107 (17%)
EFh_PI-PLC21 151..305 CDD:320043 38/153 (25%)
EF-hand motif 151..180 CDD:320043 4/28 (14%)
EF-hand motif 187..216 CDD:320043 7/28 (25%)
EF-hand motif 225..255 CDD:320043 8/29 (28%)
EF-hand motif 272..305 CDD:320043 12/32 (38%)
PI-PLCc_beta 317..702 CDD:176533 121/387 (31%)
C2_PLC_like 736..855 CDD:175974 51/151 (34%)
PTZ00121 <981..>1253 CDD:173412 36/191 (19%)
plcl1XP_012826838.2 PH_PLC_eta 79..187 CDD:270170 17/74 (23%)
EFh_PRIP1 207..349 CDD:320052 43/172 (25%)
EF-hand motif 207..236 CDD:320052 7/29 (24%)
EF-hand motif 243..275 CDD:320052 11/46 (24%)
EF-hand motif 279..307 CDD:320052 8/29 (28%)
EF-hand motif 316..349 CDD:320052 12/40 (30%)
PI-PLCc_PRIP_metazoa 361..652 CDD:176539 121/387 (31%)
C2_PLC_like 684..812 CDD:175974 51/131 (39%)

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