DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plcl2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_002932453.1	Gene:	plcl2 / 100489093	XenbaseID:	XB-GENE-949595	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	1133	Identity:	302/1133 - (26%)
Similarity:	483/1133 - (42%)	Gaps:	262/1133 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.::::||||:.....:.|.:...::       |:...::.:
Frog   152 LDADMQSLRWEPSKKDSEKAKIDIKSVKEVRTGKNTDIFRSNGIYDQIS-------EDCAFSIIY 209

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGL-IKLAYSLAQL-------NGSAIMFLQKAHTKLCLQVD 162
            |.::.::..|   ....|:|.:|..|| ..::|....|       :...|.:|.:...:  |..:
Frog   210 GENYESLDLV---ANSADVANVWVTGLRYLISYGKHTLDMIESFQDNMRISWLSQMFRE--LDEE 269

  Fly   163 KSGRIP-------VKNI------IKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFY 214
            .:|.||       :||:      .|:..:.||.:|..||.            |..|:|   ::|.
Frog   270 NTGDIPLCKAVQFIKNLNPGLKNSKIELKFKELQKSKEKV------------STEVTK---DEFI 319

  Fly   215 NLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQ 279
            .::..|..|.|:  .|..:..:|.::.:....|:.||...|....:.|.:        :.::|::
Frog   320 EVFHELCTRPEI--YFLLVQFSSNKEYLDTKDLMMFLEAEQGMAHVTEEI--------SLDIIKK 374

  Fly   280 YEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTG 344
            |||:| ..:.|.|||||...|||..|..|..|....:|.||.||:|||:||:||||||...|..|
Frog   375 YEPSK-GQETGSLSLDGLTSYLMSPDCSIFDPEHKKICQDMAQPLSHYYINASHNTYLIEDQFRG 438

  Fly   345 KSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVIL 409
            .|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|:|.|.:.|...||||:||
Frog   439 PSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIEIINKYAVYASEYPLIL 503

  Fly   410 SFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKNKKKHHH 471
            ..||||:.:||..:..:.::|.||.|       :...||.:   ||.|..|:.|::||.||
Frog   504 CLENHCSVKQQKVMVQHMKKILGDKL-------YTTSPNSEESYLPSPESLKGKLLIKGKK---- 557

  Fly   472 HHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSA 536
                                                               .|.|         .
Frog   558 ---------------------------------------------------LNSD---------C 562

  Fly   537 AGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISA 601
            :|..|                     |.:.|||.|..:......|.|.......|..:...|:|.
Frog   563 SGIEG---------------------DVTDEDEGLEMSQRVGKDGEEQQNTAPVKRVQLCKELSD 606

  Fly   602 LVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSS 666
            ||:..:.:.|:.|:.:.:..:.:|:.||:|..|.....|.|.:||||||..|||::|:..|.|||
Frog   607 LVSICKSVQFTDFQISFQNQKYWEVCSFNEVAAGKYANENPGDFVNYNKRYLSRIFPSPMRIDSS 671

  Fly   667 NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG 731
            |..||.:|..|||:||:|:||..|.|.||:|.|..|...||:|:|..||..........:.:|.|
Frog   672 NMNPQDYWKCGCQIVAMNYQTPGLMMDLNIGWFRQNGNCGYVLRPSIMREEVSFFSANTKDSVPG 736

  Fly   732 IIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDE 788
            :....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||.||::||
Frog   737 VSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVHQNGDNPIFDE 799

  Fly   789 EPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            . |.| ::.||||..:|....::   |.:.||...:|...|.||||||.|:|..|..:..||||:
Frog   800 S-FEF-QINLPELTMVRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLQSLTGDILPHASLFV 862

  Fly   851 CVVV----------------------KDYVPDDLSNFAEALANPIKYQSELEKRDIQ-LSVLTDE 892
            .|.:                      :||        |......||...|:.|..|| :...||
Frog   863 HVAITNRRGGGKPHKRGLSVRKAKKSRDY--------ASLRTLLIKSVDEVFKNAIQPIRDATD- 918

  Fly   893 AEALGSADEDLSKSFV-FVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGE 956
                  ..|::..:.| |.::.|    |.||.:|      |..|.|.:....           |.
Frog   919 ------LRENMQNTVVSFKELCG----LSPVANL------RQCIMALSTRLA-----------GP 956

  Fly   957 DSISIVAPSIQHQH---SLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEK-------R 1011
            |:..:|..::..|:   .|..:|...::::.::   .|.::......|.:...|.||       .
Frog   957 DNTPVVVMNLNEQYPTMELQGTVPEVMKRILAA---YDSIIQNSKTLIENADGVYEKIVQCQKTA 1018

  Fly  1012 LEMEKKLESLRKKHD-KEKIKIAGQKS-----SPLEGKKP--KFAITNKL--VKRLSNKSLNC-- 1064
            :|..:.|.|:..|.. ||:..:...:|     :.|:|:..  |:|.|..|  :|::...:::|
Frog  1019 MEFHENLSSIGAKEGLKERKMLKAVESFTWNITILKGQADLLKYAKTEALENLKQIHYAAVSCGL 1083

  Fly  1065 ------LSPHSEPGVEIPACPLDLGDSS 1086
                  .:..|:|...:.|.|...||.:
Frog  1084 HRPNTGNAEASKPRRSLEAIPEKAGDET 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	22/111 (20%)
		PLN02222	213..850	CDD:177868	207/650 (32%)
		EF-hand_like	225..317	CDD:286375	25/91 (27%)
		PI-PLCc_beta	317..702	CDD:176533	125/387 (32%)
		C2_PLC_like	736..855	CDD:175974	47/151 (31%)
plcl2	XP_002932453.1	PH_PLC_eta	130..238	CDD:270170	20/95 (21%)
		EFh_PI-PLC	258..400	CDD:333715	41/169 (24%)
		EF-hand motif	258..287	CDD:320029	7/30 (23%)
		EF-hand motif	294..325	CDD:320029	10/45 (22%)
		EF-hand motif	330..358	CDD:320029	6/29 (21%)
		EF-hand motif	367..399	CDD:320029	14/40 (35%)
		PI-PLCc_PRIP_metazoa	411..707	CDD:176539	125/387 (32%)
		C2_PLC_like	739..867	CDD:175974	47/131 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010