Protein Alignment Plc21C and plcl2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_002932453.1
• Gene: plcl2 / 100489093
• XenbaseID: XB-GENE-949595
• Length: 1113
• Species: Xenopus tropicalis
• Alignment Length: 1133
• Identity: 302/1133 - (26%)
• Similarity: 483/1133 - (42%)
• Gaps: 262/1133 - (23%)

  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.::::||||:.....:.|.:...::       |:...::.:
 Frog   152 LDADMQSLRWEPSKKDSEKAKIDIKSVKEVRTGKNTDIFRSNGIYDQIS-------EDCAFSIIY 209

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGL-IKLAYSLAQL-------NGSAIMFLQKAHTKLCLQVD 162
            |.::.::..|   ....|:|.:|..|| ..::|....|       :...|.:|.:...:  |..:
 Frog   210 GENYESLDLV---ANSADVANVWVTGLRYLISYGKHTLDMIESFQDNMRISWLSQMFRE--LDEE 269

  Fly   163 KSGRIP-------VKNI------IKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFY 214
            .:|.||       :||:      .|:..:.||.:|..||.            |..|:|   ::|.
 Frog   270 NTGDIPLCKAVQFIKNLNPGLKNSKIELKFKELQKSKEKV------------STEVTK---DEFI 319

  Fly   215 NLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQ 279
            .::..|..|.|:  .|..:..:|.::.:....|:.||...|....:.|.:        :.::|::
 Frog   320 EVFHELCTRPEI--YFLLVQFSSNKEYLDTKDLMMFLEAEQGMAHVTEEI--------SLDIIKK 374

  Fly   280 YEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTG 344
            |||:| ..:.|.|||||...|||..|..|..|....:|.||.||:|||:||:||||||...|..|
 Frog   375 YEPSK-GQETGSLSLDGLTSYLMSPDCSIFDPEHKKICQDMAQPLSHYYINASHNTYLIEDQFRG 438

  Fly   345 KSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVIL 409
            .|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|:|.|.:.|...||||:||
 Frog   439 PSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIEIINKYAVYASEYPLIL 503

  Fly   410 SFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKNKKKHHH 471
            ..||||:.:||..:..:.::|.||.|       :...||.:   ||.|..|:.|::||.||
 Frog   504 CLENHCSVKQQKVMVQHMKKILGDKL-------YTTSPNSEESYLPSPESLKGKLLIKGKK---- 557

  Fly   472 HHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSA 536
                                                               .|.|         .
 Frog   558 ---------------------------------------------------LNSD---------C 562

  Fly   537 AGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISA 601
            :|..|                     |.:.|||.|..:......|.|.......|..:...|:|.
 Frog   563 SGIEG---------------------DVTDEDEGLEMSQRVGKDGEEQQNTAPVKRVQLCKELSD 606

  Fly   602 LVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSS 666
            ||:..:.:.|:.|:.:.:..:.:|:.||:|..|.....|.|.:||||||..|||::|:..|.|||
 Frog   607 LVSICKSVQFTDFQISFQNQKYWEVCSFNEVAAGKYANENPGDFVNYNKRYLSRIFPSPMRIDSS 671

  Fly   667 NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG 731
            |..||.:|..|||:||:|:||..|.|.||:|.|..|...||:|:|..||..........:.:|.|
 Frog   672 NMNPQDYWKCGCQIVAMNYQTPGLMMDLNIGWFRQNGNCGYVLRPSIMREEVSFFSANTKDSVPG 736

  Fly   732 IIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDE 788
            :....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||.||::||
 Frog   737 VSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVHQNGDNPIFDE 799

  Fly   789 EPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            . |.| ::.||||..:|....::   |.:.||...:|...|.||||||.|:|..|..:..||||:
 Frog   800 S-FEF-QINLPELTMVRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLQSLTGDILPHASLFV 862

  Fly   851 CVVV----------------------KDYVPDDLSNFAEALANPIKYQSELEKRDIQ-LSVLTDE 892
            .|.:                      :||        |......||...|:.|..|| :...||
 Frog   863 HVAITNRRGGGKPHKRGLSVRKAKKSRDY--------ASLRTLLIKSVDEVFKNAIQPIRDATD- 918

  Fly   893 AEALGSADEDLSKSFV-FVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGE 956
                  ..|::..:.| |.::.|    |.||.:|      |..|.|.:....           |.
 Frog   919 ------LRENMQNTVVSFKELCG----LSPVANL------RQCIMALSTRLA-----------GP 956

  Fly   957 DSISIVAPSIQHQH---SLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEK-------R 1011
            |:..:|..::..|:   .|..:|...::::.::   .|.::......|.:...|.||       .
 Frog   957 DNTPVVVMNLNEQYPTMELQGTVPEVMKRILAA---YDSIIQNSKTLIENADGVYEKIVQCQKTA 1018

  Fly  1012 LEMEKKLESLRKKHD-KEKIKIAGQKS-----SPLEGKKP--KFAITNKL--VKRLSNKSLNC-- 1064
            :|..:.|.|:..|.. ||:..:...:|     :.|:|:..  |:|.|..|  :|::...:::|
 Frog  1019 MEFHENLSSIGAKEGLKERKMLKAVESFTWNITILKGQADLLKYAKTEALENLKQIHYAAVSCGL 1083

  Fly  1065 ------LSPHSEPGVEIPACPLDLGDSS 1086
                  .:..|:|...:.|.|...||.:
 Frog  1084 HRPNTGNAEASKPRRSLEAIPEKAGDET 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	22/111 (20%)
		EFh_PI-PLC21	151..305	CDD:320043	40/166 (24%)
		EF-hand motif	151..180	CDD:320043	7/41 (17%)
		EF-hand motif	187..216	CDD:320043	6/28 (21%)
		EF-hand motif	225..255	CDD:320043	6/29 (21%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	125/387 (32%)
		C2_PLC_like	736..855	CDD:175974	47/151 (31%)
		PTZ00121	<981..>1253	CDD:173412	26/131 (20%)
plcl2	XP_002932453.1	PH_PLC_eta	130..238	CDD:270170	20/95 (21%)
		EFh_PI-PLC	258..400	CDD:333715	41/169 (24%)
		EF-hand motif	258..287	CDD:320053	7/30 (23%)
		EF-hand motif	294..325	CDD:320053	10/45 (22%)
		EF-hand motif	330..358	CDD:320053	6/29 (21%)
		EF-hand motif	367..399	CDD:320053	14/40 (35%)
		PI-PLCc_PRIP_metazoa	411..707	CDD:176539	125/387 (32%)
		C2_PLC_like	739..867	CDD:175974	47/131 (36%)