DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plcd1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_031759597.1 Gene:plcd1 / 100488677 XenbaseID:XB-GENE-1013054 Length:784 Species:Xenopus tropicalis


Alignment Length:839 Identity:270/839 - (32%)
Similarity:394/839 - (46%) Gaps:164/839 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 TMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVC 104
            |:..|:|.||     ::.|.....:..|.|||||.     :..::::.....|.|        :|
 Frog    72 TVWYDSKKFF-----KSQESQAFSVDDIEDVRTGH-----QTEEMQRFAAGTPPD--------LC 118

  Fly   105 HGSDFVNM-TFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKA----HTKLCLQ---V 161
            ....|... ..:|...|....|..|..|..|:..:...:|.:     ||.    |:  ||:   .
 Frog   119 FSIIFKGQRKNLNLIATDEKEAAHWVSGFNKILATSKAMNQT-----QKVQHWIHS--CLRKADK 176

  Fly   162 DKSGRIPVKNIIKLFAQ------NKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYL 220
            ||..|:.:|. :|.|.|      ::...|::.:..|.:  .||.::...:.:|        ||.|
 Frog   177 DKDNRMTLKE-LKGFLQEVNIETDESYAKQIFQHCDKS--QSGTLEGEEIEEF--------YKIL 230

  Fly   221 TQRSEVERLFDSIV--GNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPN 283
            |:|.|::.:|.:..  ||    .||...|:.||.:.||:.         |....||.||.:|||:
 Frog   231 TEREEIDVIFATYADGGN----FMSSDNLIRFLQQEQRES---------AGAEYAKSLIDKYEPS 282

  Fly   284 KFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSV 348
            :...::..::.||||.||:.||..:...:...:..||.||:|||||:|||||||...||.|.||.
 Frog   283 EQAKKQEAMTKDGFLIYLLSDDGNLFNAAHRKVYQDMKQPLSHYFISSSHNTYLMEDQLAGPSST 347

  Fly   349 EIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFEN 413
            |.|.:.|..||||||||.|:|...||:|.||||...:|..|||:.||.:.|||||.||||||.||
 Frog   348 EAYIRALSKGCRCVELDCWDGPNSEPIIYHGYTLTSKILFKDVIAAIKKYAFKTSPYPVILSLEN 412

  Fly   414 HCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHH 478
            ||...||.|:||:.:.|.|||||..||:....|    .|.|..|:.||::|.||.          
 Frog   413 HCTLEQQIKMANHMKSILGDMLLLAPLEGKLKE----FPSPEELKGKILVKGKKL---------- 463

  Fly   479 KKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHA 543
                        |||                     :..|.|.:.||                  
 Frog   464 ------------NKL---------------------EESVRRQSGNG------------------ 477

  Fly   544 PPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQP 608
                          |:...|.|.|||:.......:.|..:....||  :.:...|:|..|.|.:.
 Frog   478 --------------GAEAEDVSDEDEAAEMADEAVRSKVQEAKRKA--KLKLAKELSDTVVYCKS 526

  Fly   609 IHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLF 673
            :||..|:.|.:....|||||..|.:|..|..:...:|:.:|..||:|:||.|.|.||||:.|...
 Frog   527 VHFGGFDYALEHQSFYEMSSLAEDKALKLANDSGNKFIKHNTRQLTRIYPDGFRTDSSNYGPVEL 591

  Fly   674 WNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG--IIAGT 736
            ||.|||:|||||||....|.|..|.|:.|...||:|||:|:|:||.|.:|  .|..||  .....
 Frog   592 WNVGCQIVALNFQTPCPEMDLYQGRFQDNGACGYVLKPQFLRQSDSRFNP--RSIQDGEWWTPKK 654

  Fly   737 VSITVLSGQFL--TDKRANTFVE----VDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKK 795
            :.|.|:|||.|  .:|:.::.|:    ::::|:..|...|  .|:.:::||.||.::|. |.| :
 Frog   655 LHIMVISGQQLPKVNKKPSSIVDPVIRMEIHGVERDKGHK--HTQVMKNNGFNPTWNEN-FEF-E 715

  Fly   796 VVLPELASIRIAAYEEG----GKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            :.:|.||.:|:...:..    ...||...:|:..|..||||::|.|:.|.....|:||:
 Frog   716 IDVPALAVLRVVVEDHDAATRNDFIGQFTVPLTSLKLGYRHIHLLSKSGDQYPSATLFV 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 23/105 (22%)
EFh_PI-PLC21 151..305 CDD:320043 47/168 (28%)
EF-hand motif 151..180 CDD:320043 12/41 (29%)
EF-hand motif 187..216 CDD:320043 4/28 (14%)
EF-hand motif 225..255 CDD:320043 9/31 (29%)
EF-hand motif 272..305 CDD:320043 13/32 (41%)
PI-PLCc_beta 317..702 CDD:176533 146/384 (38%)
C2_PLC_like 736..855 CDD:175974 37/125 (30%)
PTZ00121 <981..>1253 CDD:173412
plcd1XP_031759597.1 PH_PLC_delta 44..161 CDD:270169 23/111 (21%)
EF-hand_10 181..230 CDD:405477 12/59 (20%)
PLN02228 234..781 CDD:177873 225/641 (35%)
PI-PLCc_delta 316..620 CDD:176535 146/384 (38%)
Blue background indicates that the domain is not in the aligned region.

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