DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plch2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_031761350.1	Gene:	plch2 / 100487353	XenbaseID:	XB-GENE-988591	Length:	1578	Species:	Xenopus tropicalis

Alignment Length:	1450	Identity:	362/1450 - (24%)
Similarity:	578/1450 - (39%)	Gaps:	365/1450 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVR 71
            ::|.|.:.|:            :|..:||.. .|::|::           ||...:.|.:|::|.
Frog    43 SMQAGTQMIK------------LRGSSKGLVRFYYLDEHKSCIRWRPSRKNEKAKISIDSIQEVC 95

  Fly    72 TGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL---- 132
            .|      |.:::.|....|..|  .....::.:|....::..|:   :..:.|:.|..||
Frog    96 EG------KQSEIFQRYADGSFD--PNCCFSIYYGDHMESLDLVS---SSGEEARTWITGLKYLM 149

  Fly   133 --IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGR--IPVKNIIKLFAQNKEDRKRVEKALDVT 193
              |....||::...:...:|::...    :.||:|.  :.:..:::|..:           |:|
Frog   150 AGISDEDSLSKRQRTRDQWLKQTFD----EADKNGDGCLSINEVLQLMHK-----------LNV- 198

  Fly   194 GLPSGKVDSI--------SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEF 250
            .||..||..:        :.....|::|...||.:                |.|:.:.:..|...
Frog   199 NLPRQKVKQMFKEADTDDNQGTLGFDEFCAFYKMM----------------STRRDLYLLMLTYS 247

  Fly   251 LNKTQRDP----RLNEILYPYANPAR--AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIM 309
            .:|...||    |..|:.....|..:  ..:::.::||...|.::|.|.:|||..|:......|.
Frog   248 NHKDHLDPDDLKRFLEVEQKMINVTKEYCLDIVDKFEPCPENKKQGALGIDGFTNYMRSPAGDIF 312

  Fly   310 APSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEP 374
            .|....:..||..|:|:|||.|||||||.|.||..:|.|::|...|.|||||||:|.|:|...||
Frog   313 NPDHYQVNQDMTLPLSNYFIASSHNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEP 377

  Fly   375 VIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKP 439
            ::.||||...:|..|||:|.|.:.||..::||||||.||||:..||.|:|.|..||.|:.|   .
Frog   378 IVHHGYTLTSKILFKDVIETINKYAFIRNDYPVILSIENHCSVVQQKKMAQYLIEILGEKL---N 439

  Fly   440 LDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD---- 500
            |.....|.:..||.|..||.||::|.|            |.||.:...|....::..:|.|
Frog   440 LSDVVNEDSTKLPSPESLRGKILVKGK------------KLPASISDDAEEGDVSDEDSADEIDD 492

  Fly   501 ------------AKAAQQVGLSASHEDGGV------TRSTANGDVATGTGTGSAAGTAGHAPPLQ 547
                        |...|...::....|..:      .|...|....|   |...:|.....|.|:
Frog   493 DCKLINGDWKASANRKQVENIAKKKLDSLLKESKIRDREDPNNFTVT---TLPPSGKLSQKPELK 554

  Fly   548 QIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEK------------------------ 588
            :     |.|:||..      :.:|..|.....||.||.|.|
Frog   555 K-----KCSSGSKG------ERALSKTEEEAESGEEPSPNKRHSRSLIGSFSKHKKKGGKIKKCS 608

  Fly   589 --------------------------AQKET-EAGAEISALVNYVQPIHFSSFENAEKKNRC-YE 625
                                      .||:| :....:|.||.|.:.:   ...:.|.:..| ::
Frog   609 SLEEGDESLDRQGSLARASVHYSRINRQKKTMKLSRALSDLVKYTKSV---GIHDVETEISCSWQ 670

  Fly   626 MSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDL 690
            :|||.|.:|..:|:::|.:||.:|:|||||:||:..|.||||:.||.||||||||||||:|:...
Frog   671 VSSFSETKAHQILQQKPAQFVRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQLVALNYQSEGR 735

  Fly   691 AMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR---- 751
            .:|||...|..|...||:|||:.|.:.  ..:|.:|..:.|.:...:.:.::|||.|...:
Frog   736 MLQLNRAKFNSNGNCGYVLKPKCMCQG--AFNPNSEDPLPGQLKKQLVLRIISGQQLPKPKDSML 798

  Fly   752 ------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE 810
                  .:.||||::.|||.|..::  :|:.|.|||.||:: ||..|| .|.:||::.||...::
Frog   799 GDRGEIIDPFVEVELIGLPVDCFKE--QTRVVDDNGFNPMW-EETLVF-TVHMPEISLIRFLVWD 859

  Fly   811 E---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEA---- 868
            .   |...||.|.|....:.||||||.|     :.:..||:|:.|.:.| :...:...|..
Frog   860 HDPIGRDFIGQRTLSFSSMMPGYRHVYL-----EGMEEASIFVHVAIND-ISGKVKQAAGLKGLF 918

  Fly   869 LANPIKYQSELE---------KRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVES 924
            |.||  .|:.|:         |..|...:|...|.|               ...||:|..:....
Frog   919 LRNP--KQASLDSHAAGQLHRKHSISSHILRRTASA---------------PTKGQQKNKKGFPE 966

  Fly   925 LATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVST---------SI 980
            :|...|.    :::...|.|...|.:...|.|......:|::..:...:..:::         ||
Frog   967 IAIDSKE----NSSDGPSEDRETDDSSLPRFEKDPESASPALPSRDGTNVELNSKGLKDPRQLSI 1027

  Fly   981 RQVESSQFDVDLVLAEPL---EKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEG 1042
            .:..||...::.:..|||   ||    .|...:.:......||......||.   ..:.|||
Frog  1028 YRSASSLCSLETIKEEPLFAKEK----PSTSPQPVACFTSCESTACDQYKES---QSECSSP--- 1082

  Fly  1043 KKPKFAITNKLVKRLSNKSL-----------NCLSPHSEPGVEIPACPLDLGDSSEESAAADA-G 1095
                 |||::.|:|.|..::           |.|.||:             |..:...|..|. |
Frog  1083 -----AITSENVQRPSKLNVEPAIIKVLAISNGLHPHN-------------GKLNPGKAYNDRNG 1129

  Fly  1096 EDLA--GGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKAS 1158
            :.|:  .|.|........|.::..........|.:.|:|.          :|.:|..|: .:.||
Frog  1130 KVLSSVSGKSDCTNLINSSLIKPGLSLLADVSRNVNEQYQ----------VKANQAAQS-SIHAS 1183

  Fly  1159 LDKVTGEVM------HQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTF 1217
            ...|...:|      |  |.:.:..:|:|......|.:..|  .:...|||..|
Frog  1184 NTSVANRIMCTNLPDH--QTSSKPNMKHLIVPPVQRSQYDR--PDSKPSVVHAG----------- 1233

  Fly  1218 DRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLFHGP------------HH 1270
                     :|..||.|    :|:...:.|..|.|.:....:....::...            :.
Frog  1234 ---------KHTPVRRA----KSEGYVVSDCSALSLNSTCQSPVAEVYSDATVNDRIWSKLELNS 1285

  Fly  1271 HGCTGSGSSALSGNNLTLNL 1290
            |..:.|.||:.|.|:..::|
Frog  1286 HRDSMSSSSSKSSNDTVIDL 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/142 (19%)
		PLN02222	213..850	CDD:177868	228/729 (31%)
		EF-hand_like	225..317	CDD:286375	20/97 (21%)
		PI-PLCc_beta	317..702	CDD:176533	153/458 (33%)
		C2_PLC_like	736..855	CDD:175974	44/131 (34%)
plch2	XP_031761350.1	PH_PLC_eta	44..150	CDD:270170	24/128 (19%)
		EFh_PI-PLCeta2	168..308	CDD:320051	33/171 (19%)
		PI-PLCc_GDPD_SF	320..747	CDD:417475	153/458 (33%)
		C2_PLC_like	777..901	CDD:175974	44/132 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010