DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and plch2a

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_009302541.1	Gene:	plch2a / 100334231	ZFINID:	ZDB-GENE-030131-6367	Length:	1557	Species:	Danio rerio

Alignment Length:	1412	Identity:	368/1412 - (26%)
Similarity:	592/1412 - (41%)	Gaps:	328/1412 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TGTP-VTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVRTGQYAKRPKDNKLRQ 86
            |||. |.:|..:||.. .:::|::           ||...:.|.:||:|..|      |.:::.|
Zfish    88 TGTQMVKLRGGSKGLVRFFYLDEHKSCIRWRPSRKNEKAKISIDSIREVCEG------KQSEIFQ 146

  Fly    87 IVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------IKLAYSLAQLNGS 145
            ..:.|..|  .....::.:|....::..|:   ...:.|:.|..||      |....|||:...:
Zfish   147 RYSDGSFD--PNCCFSIYYGEHMESLDLVS---GTGEEARTWITGLKYLMAGISDEDSLAKRQRT 206

  Fly   146 AIMFLQKAHTKLCLQVDKSGR--IPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSI----- 203
            ...:|::...    :.||:|.  :.:..:::|..:           |:| .||..||..:
Zfish   207 RDQWLKQTFA----EADKNGDGCLSISEVLQLLHK-----------LNV-NLPRQKVKQMFKEAD 255

  Fly   204 ---SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILY 265
               :.....||:|.:.||.::.|.::..|.  :..::.:..:....|..||...|:...:::
Zfish   256 TDDNQGTLGFEEFCSFYKMMSTRRDLYLLM--LTYSNHKDHLDTDDLKRFLETEQKMTNVSK--- 315

  Fly   266 PYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFIN 330
                 ....|::.::||...|...|.|.:|||..|:......|..|...::..||.||:|.|||.
Zfish   316 -----EHCLEIVAKFEPCPENQTSGVLGIDGFTNYMRSPAGDIFNPEHYEVNQDMTQPLSDYFIA 375

  Fly   331 SSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAI 395
            |||||||.|.||..:|.|::|...|.|||||||:|.|:|:..||::.||||...:|..|||:|.|
Zfish   376 SSHNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGQDGEPIVHHGYTLTSKILFKDVIETI 440

  Fly   396 AESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRK 460
            .:.||..::||||||.||||:..||.|:|.|..|:.||.|   .:.|.|.:|:..||.|..|:.|
Zfish   441 NKYAFAKNQYPVILSIENHCSVPQQKKMAQYLTEVLGDKL---DVSSIPADPSGLLPSPEALKGK 502

  Fly   461 IIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD----------------AKAAQQVG- 508
            |:||.|            |.|:.:...|....::..:|.|                .|.|:.|.
Zfish   503 ILIKGK------------KLPSNIDENAEEGDVSDEDSADEMEDDCKLLNGDTSMNRKQAENVAK 555

  Fly   509 ----------------------LSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQI-- 549
                                  ::|....|...:|...|.....|.||..|...|:....:..
Zfish   556 KKLDNLMKESKIRDREDPDSFTITALPPSGKHDKSPLKGKAEDSTDTGDEANIGGNKRLARTFMG 620

  Fly   550 ------RQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQP 608
                  :::||....||..|:.::.||  ::..:....:....:|..|.:.|   :|.|| |::.
Zfish   621 SFSKRKKKTSKVKKSSSFEDTDTDQES--SSGASKAQAHHSRKKKTMKLSRA---LSDLV-YMKS 679

  Fly   609 IHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLF 673
            :....||:   :...:::||..|.:|..|::::|:.|:.:|:.|||||||:..|.|||||.||.|
Zfish   680 VGMPDFES---QGVTWQVSSMSETKAHQLIQQKPVPFMRFNQRQLSRVYPSPYRVDSSNFNPQPF 741

  Fly   674 WNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVS 738
            |||||.|||||:|:....:|||...|..|...||:.||..:  .:...:|.||..:.|.:...:.
Zfish   742 WNAGCHLVALNYQSEGRVLQLNRAKFYCNGNCGYIQKPGCL--CEGSFNPVAEDPLPGRLKKQLI 804

  Fly   739 ITVLSGQFLTDKR----------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVF 793
            :.|:|||.|...:          .:.||||::.|||.|..::  :|:.|.|||.||:: ||..||
Zfish   805 LKVISGQQLPKPKDSMLGDRGEIIDPFVEVEIIGLPVDCCKE--QTRVVDDNGFNPMW-EETLVF 866

  Fly   794 KKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVK 855
             .:.:||.|.||...::.   |...||.|.:....:.||||||.|     :.:..||:|:.|.|
Zfish   867 -TLHMPENALIRFLVWDHDPIGQDFIGQRTIAFNSMIPGYRHVYL-----EGMEEASIFVHVAV- 924

  Fly   856 DYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELR 920
                :|:::.|.|::. ||   .|..|:.:.:.|...|.||      |::...|   |...  ||
Zfish   925 ----NDITSKARAVSG-IK---GLFHRNPKQASLDSHAAAL------LNRKSTF---GAHL--LR 970

  Fly   921 PVESLATSPKHRPSISAA-AAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVE 984
            ...|..|  |.:|.:... ..:|:| |.|.:..|..|:..|...|.:.|..  |.:.:.|..|..
Zfish   971 RTASAPT--KGQPKVKRGFPEISID-TKDCSSDGASEERESEEGPLVHHNG--DTASAKSWGQGT 1030

  Fly   985 SSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAI 1049
            :.|.               |...:::..|::....||... ..|.|....|::||
Zfish  1031 NGQL---------------HPDDRKENSEVQSPTPSLNAS-CLESITENFQENSP---------- 1069

  Fly  1050 TNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESA--AADAGEDLA------------- 1099
                  ..|.:|....|||         |||    ||..:|  |:..||:|:
Zfish  1070 ------STSTQSPVDTSPH---------CPL----SSPSTAITASSNGENLSPVKNNEDILKSFA 1115

  Fly  1100 ---------GGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQL 1155
                     .|:|.::.....:.|...|...|.      ..:|.|....|::.: .:|||.|.::
Zfish  1116 LTQSTSGKDSGNSPVNSSISTNYLDIGCDTPTF------PTFHRADGEVAQETV-INQTGLTLEI 1173

  Fly  1156 KASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRR 1220
            .|      |:....:|.::|.:.                                  ||..|||
Zfish  1174 DA------GKEPTAIQSSQRIQA----------------------------------LKAVFDR- 1197

  Fly  1221 TDELQKQHDSVRNALAEHRSKARQILDKEAESRSCV-------SSNGFLVLFHGPHHHGCTGSGS 1278
             |..:.....:|..:...:|:.:.   |:|:..|.|       :.|..|.....|..|..:.|.|
Zfish  1198 -DIGRSMQTGLRTPVRRSKSEGQM---KKADGPSVVPEVCTDATLNDRLWSKLDPSSHRDSVSSS 1258

  Fly  1279 SALSGNNLTLNLD-----------AGAAGSHS--AISPAKSHNSIAA 1312
            |::|.|:..::|.           ..||..:|  ..|...:|.|:.|
Zfish  1259 SSISSNDTVIDLSLPNLSRKSLTCLSAARDYSDKQASLTNNHRSVIA 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	29/128 (23%)
		PLN02222	213..850	CDD:177868	221/696 (32%)
		EF-hand_like	225..317	CDD:286375	17/91 (19%)
		PI-PLCc_beta	317..702	CDD:176533	149/431 (35%)
		C2_PLC_like	736..855	CDD:175974	44/131 (34%)
plch2a	XP_009302541.1	PH_PLC_eta	86..192	CDD:270170	25/114 (22%)
		EFh	210..276	CDD:238008	16/81 (20%)
		EF-hand_7	211..272	CDD:290234	14/76 (18%)
		PLN02952	252..910	CDD:178538	220/697 (32%)
		EF-hand_like	280..361	CDD:286375	17/90 (19%)
		PI-PLCc_GDPD_SF	362..770	CDD:301322	149/431 (35%)
		C2_PLC_like	800..924	CDD:175974	44/132 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586429
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750