DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K21B and pik3r3

DIOPT Version :9

Sequence 1:	NP_001259817.1	Gene:	Pi3K21B / 33203	FlyBaseID:	FBgn0020622	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001017229.1	Gene:	pik3r3 / 549983	XenbaseID:	XB-GENE-6464721	Length:	461	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	158/446 - (35%)
Similarity:	228/446 - (51%)	Gaps:	60/446 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQAPGSLVDPNED-------ELRMAPWYWGRISREEAKSILHGKPDGSFLVRDA-LSMKGEYTLT 59
            |:.|.|:...:.|       .|:.|.||||.|||||....|...|||:|||||| ..::|:||||
Frog    39 PKPPKSMTSLSTDGSKENSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLT 103

  Fly    60 LMKDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEE 124
            |.|.|..|||||.|.|.||||.:...||||||:||:|:..||:.||..||:.|..|:.|.::|:
Frog   104 LRKGGNNKLIKIYHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQDQ- 167

  Fly   125 SQPHGDLCLLSNEFIRTC-QLLQNLEQNLENKRNSFNAIRE-------ELQEKKLHQSVFGNTEK 181
                    |:..:.|... :.||......::|...::.:.|       |:|.|:.....|..|.|
Frog   168 --------LVKEDNIDAVGRKLQEYHGQFQDKSKEYDKLYEEYTKTSQEIQMKRTAIEAFNETIK 224

  Fly   182 IFRNQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKG 246
            ||..|....|.:.|...:                     ..|...:.:|.::.::|........|
Frog   225 IFEEQCHTQERYSKEYME---------------------RFNREGNEKEMERIIMNYEKLKSRLG 268

  Fly   247 QVLNHYM---ENKKKEEL---LLERQINALKPELQILQLRK--DKYIERL--KGFNLKD-DDLKM 300
            ::.:..:   ::.||:.|   .:::::|::||:|  :||||  |:|:..|  ||...|. :|...
Frog   269 EIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDL--IQLRKIRDQYLVWLNHKGVRQKRINDWLG 331

  Fly   301 ILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYALSIA 364
            |.....|....:.|...|.||.:|..|.:.|..|..|||:|.|.|.|.|||| :...|.||.|:.
Frog   332 IKNENIDDTYFVSEEDDNLPHYDEKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKKGCYACSVV 396

  Fly   365 CKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420
            ....|:||:||.||.|:|||.|||:|:|||.||.||.:.||.:|||:|...|.:||
Frog   397 ADGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K21B	NP_001259817.1	SH2_nSH2_p85_like	14..123	CDD:198195	59/116 (51%)
		PI3K_P85_iSH2	129..302	CDD:293063	39/191 (20%)
		iSH2_PI3K_IA_R	138..303	CDD:304922	39/183 (21%)
		SH2_cSH2_p85_like	320..422	CDD:198184	52/102 (51%)
pik3r3	NP_001017229.1	SH2_nSH2_p85_like	59..167	CDD:198195	58/107 (54%)
		iSH2_PI3K_IA_R	172..332	CDD:355389	38/182 (21%)
		SH2_cSH2_p85_like	351..454	CDD:198184	52/102 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7333
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3345
OMA	1	1.010	-	-		QHG46664
OrthoDB	1	1.010	-	-		D323393at33208
OrthoFinder	1	1.000	-	-		FOG0001513
OrthoInspector	1	1.000	-	-		otm47559
Panther	1	1.100	-	-	O	PTHR10155
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1082
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080