DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K21B and PIK3R2

DIOPT Version :10

Sequence 1:NP_477270.2 Gene:Pi3K21B / 33203 FlyBaseID:FBgn0020622 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_005018.2 Gene:PIK3R2 / 5296 HGNCID:8980 Length:728 Species:Homo sapiens


Alignment Length:445 Identity:159/445 - (35%)
Similarity:222/445 - (49%) Gaps:62/445 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PQA-PGSLVDPN---EDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS-MKGEYTLTLMK 62
            |:| |.|.|..|   ...|:.|.||||.|||||....|...|||:||||||.| ::|||||||.|
Human   307 PKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRK 371

  Fly    63 DGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQP 127
            .|..||||:.|.|..|||.|...|.|||::||:|:..||:.||..||..|..|:.:.::|:    
Human   372 GGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQ---- 432

  Fly   128 HGDLCLLSNEFIRTC-QLLQNLEQNLENKRNSFNAIRE-------ELQEKKLHQSVFGNTEKIFR 184
                 ::..:.:... ..|:...|..::|...::.:.|       |||.|:.....|..|.|||.
Human   433 -----IVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFE 492

  Fly   185 NQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVL 249
            .|.:..|...|...:                       ..||...| |:....||::.:.|.::.
Human   493 EQGQTQEKCSKEYLE-----------------------RFRREGNE-KEMQRILLNSERLKSRIA 533

  Fly   250 NHYMENKKKEELL---------LERQINALKPELQILQLRK--DKYIERL--KGFNLKDDDLKMI 301
            ..:....|.|:.|         :::::|:|||:|  :||||  |:|:..|  ||...|..:..:.
Human   534 EIHESRTKLEQQLRAQASDNREIDKRMNSLKPDL--MQLRKIRDQYLVWLTQKGARQKKINEWLG 596

  Fly   302 LQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYALSIAC 365
            ::...:....|.|...:.||..|..|.:....|..|||||.|...|||||| :...|.||.|:..
Human   597 IKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV 661

  Fly   366 KNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420
            ....:||:||.|:||||||.|||:|.:||.||.||.:.||.:|||.||.||..||
Human   662 DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K21BNP_477270.2 SH2_nSH2_p85_like 14..123 CDD:198195 56/109 (51%)
PI3K_P85_iSH2 120..303 CDD:465121 42/203 (21%)
SH2_cSH2_p85_like 320..422 CDD:198184 53/102 (52%)
PIK3R2NP_005018.2 SH3_PI3K_p85beta 7..80 CDD:212842
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..117
RhoGAP 110..296 CDD:470621
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..279
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..320 6/12 (50%)
SH2_nSH2_p85_like 322..432 CDD:198195 56/109 (51%)
iSH2_PIK3R2 437..597 CDD:214019 41/185 (22%)
SH2_cSH2_p85_like 615..717 CDD:198184 53/102 (52%)
Blue background indicates that the domain is not in the aligned region.

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