DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K21B and PIK3R1

DIOPT Version :9

Sequence 1:NP_001259817.1 Gene:Pi3K21B / 33203 FlyBaseID:FBgn0020622 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_852664.1 Gene:PIK3R1 / 5295 HGNCID:8979 Length:724 Species:Homo sapiens


Alignment Length:449 Identity:148/449 - (32%)
Similarity:232/449 - (51%) Gaps:70/449 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 RPQAPGSLVD---PNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDA-LSMKGEYTLTLMK 62
            :|..|.::.:   .|...|:.|.||||.|||||....|....||:|||||| ..|.|:|||||.|
Human   310 KPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRK 374

  Fly    63 DGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQP 127
            .|..|||||.|.|.||||.:...|:||||:||:|:..||:.||..||:.|..|:.:.::|:    
Human   375 GGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQ---- 435

  Fly   128 HGDLCLLSNEFIRTC-QLLQNLEQNLENKRNSFNAIRE-------ELQEKKLHQSVFGNTEKIFR 184
                 ::..:.|... :.|.......:.|...::.:.|       |:|.|:.....|..|.|||.
Human   436 -----VVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE 495

  Fly   185 NQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVL 249
            .|.:..|.:.|...:....|..                      ::..|.:::..|.|:::   :
Human   496 EQCQTQERYSKEYIEKFKREGN----------------------EKEIQRIMHNYDKLKSR---I 535

  Fly   250 NHYMENKKK-EELL---------LERQINALKPELQILQLRK--DKYIERL--KGFNLKDDDLKM 300
            :..:::::: ||.|         :::::|::||:|  :||||  |:|:..|  ||...|    |:
Human   536 SEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL--IQLRKTRDQYLMWLTQKGVRQK----KL 594

  Fly   301 ILQMGFDKWQQLYETVSNQ---PHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYAL 361
            ...:|.:..:..|..|.:.   ||.:|..|.:..:.|..||.:|:|...||||:| :...|.||.
Human   595 NEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC 659

  Fly   362 SIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420
            |:.....|:||:|.:|:||:|||.|||:|::||.||.||.:.||.:|||:|..||.:||
Human   660 SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K21BNP_001259817.1 SH2_nSH2_p85_like 14..123 CDD:198195 56/109 (51%)
PI3K_P85_iSH2 129..302 CDD:293063 37/194 (19%)
iSH2_PI3K_IA_R 138..303 CDD:304922 37/186 (20%)
SH2_cSH2_p85_like 320..422 CDD:198184 48/102 (47%)
PIK3R1NP_852664.1 SH3_PI3K_p85alpha 5..79 CDD:212843
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 80..108
RhoGAP_p85 114..302 CDD:239853
SH2_nSH2_p85_like 325..435 CDD:198195 56/109 (51%)
iSH2_PIK3R1 440..600 CDD:214017 37/190 (19%)
SH2_cSH2_p85_like 617..720 CDD:198184 48/102 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 95 1.000 Domainoid score I7410
eggNOG 1 0.900 - - E1_KOG4637
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 227 1.000 Inparanoid score I3483
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323393at33208
OrthoFinder 1 1.000 - - FOG0001513
OrthoInspector 1 1.000 - - otm40387
orthoMCL 1 0.900 - - OOG6_103810
Panther 1 1.100 - - LDO PTHR10155
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1082
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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