DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K21B and Socs36E

DIOPT Version :9

Sequence 1:	NP_001259817.1	Gene:	Pi3K21B / 33203	FlyBaseID:	FBgn0020622	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster

Alignment Length:	297	Identity:	68/297 - (22%)
Similarity:	132/297 - (44%)	Gaps:	63/297 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALSMKGEYTLTLMKDGCEKLIKICHMDR 76
            |:.:::..:.:|||::.|.||:.:|.|||:|:||:||:...:..:::|..|.|.....:|.....
  Fly   464 PDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGH 528

  Fly    77 KYGFIETD--LFN--SVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPHGDLCLLSN- 136
            |:.|...|  :|.  :|..::.:||:.:..|:   .:..|:.|:.| |:....|......::||
  Fly   529 KFSFDCHDPCVFTAPTVTGLLEHYKDPACVMF---FEPCLTIPLHR-RQTFSLQQLSRATIVSNT 589

  Fly   137 --EFIRTCQLLQNLEQNLENKRNSFNAIREELQEKKLHQSV----FGNTEKIFRNQIKLNESFMK 195
              :.|...:|...|:..|:...     .:::|:.|.:.|:.    :||   :.|.:.::..::.:
  Fly   590 SYDGINQMELPGRLKSYLKEYH-----YKQKLRVKPIDQNTPMPYYGN---VXREEQQVGFTYYE 646

  Fly   196 APADAPSTEAGGAGD-----GAN--------------------AAASAAANANARRSLQEHKQTL 235
                  ..|:|...|     |.|                    |:..:|.:::...:||||...|
  Fly   647 ------DVESGSEVDEDDDEGVNIRVSYVQHAEVVAQLQQVTTASGPSAPSSSRSSNLQEHLSRL 705

  Fly   236 LNLLDALQAKGQV---LNHYMENKKKEELLLERQINA 269
            .|.:.|  |.|::   ||.|    :|.....||..|:
  Fly   706 PNRMAA--AFGRMSANLNCY----QKTVATPERHSNS 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K21B	NP_001259817.1	SH2_nSH2_p85_like	14..123	CDD:198195	31/112 (28%)
		PI3K_P85_iSH2	129..302	CDD:293063	35/176 (20%)
		iSH2_PI3K_IA_R	138..303	CDD:304922	33/164 (20%)
		SH2_cSH2_p85_like	320..422	CDD:198184
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	28/101 (28%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10155
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010