DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K21B and Pik3r2

DIOPT Version :9

Sequence 1:	NP_001259817.1	Gene:	Pi3K21B / 33203	FlyBaseID:	FBgn0020622	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_038950364.1	Gene:	Pik3r2 / 29741	RGDID:	68341	Length:	741	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	154/451 - (34%)
Similarity:	218/451 - (48%)	Gaps:	81/451 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 APGSLVD-PNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS-MKGEYTLTLMKDGCEK 67
            ||.:|.: .:...|:.|.||||.|||||....|...|||:||||||.| ::|||||||.|.|..|
  Rat   325 APTALANGGSTPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNK 389

  Fly    68 LIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPHGDLC 132
            |||:.|.|..|||.|...|.||||:|::|:..||:.||..||..|..|:.:.::|:
  Rat   390 LIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQ--------- 445

  Fly   133 LLSNEFIRTC-QLLQNLEQNLENKRNSFNAIRE-------ELQEKKLHQSVFGNTEKIFRNQIKL 189
            ::..:.:... ..|:...|..::|...::.:.|       |||.|:.....|..|.|||..|.:.
  Rat   446 VVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQT 510

  Fly   190 NESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVLNHYME 254
            .|...|...:                       ..||...| |:....||::.:.|.::...:..
  Rat   511 QEKCSKEYLE-----------------------RFRREGNE-KEMQRILLNSERLKSRIAEIHES 551

  Fly   255 NKKKEELL---------LERQINALKPELQILQLRKDKYIERLKGFNLKDDDLKMILQMG----- 305
            ..|.|:.|         :::::|:|||:|  :||||           ::|..|..:.|.|
  Rat   552 RTKLEQDLRAQASDNREIDKRMNSLKPDL--MQLRK-----------IRDQYLVWLTQKGARQRK 603

  Fly   306 FDKWQQLYETVSNQ----------PHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHY 359
            .::|..:.....:|          ||..|..|.:....|..|||||.|...|||||| :...|.|
  Rat   604 INEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCY 668

  Fly   360 ALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420
            |.|:......:||:||.|:||||||.|||:|.:||.||.||.:.||.:|||.||.||..||
  Rat   669 ACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K21B	NP_001259817.1	SH2_nSH2_p85_like	14..123	CDD:198195	56/109 (51%)
		PI3K_P85_iSH2	129..302	CDD:293063	37/189 (20%)
		iSH2_PI3K_IA_R	138..303	CDD:304922	37/181 (20%)
		SH2_cSH2_p85_like	320..422	CDD:198184	53/102 (52%)
Pik3r2	XP_038950364.1	SH3_PI3K_p85beta	7..80	CDD:212842
		RhoGAP	110..321	CDD:413382
		SH2_nSH2_p85_like	337..445	CDD:198195	56/107 (52%)
		iSH2_PIK3R2	450..610	CDD:214019	40/196 (20%)
		SH2_cSH2_p85_like	628..730	CDD:198184	53/102 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338060
Domainoid	1	1.000	94	1.000	Domainoid score	I7275
eggNOG	1	0.900	-	-		E1_KOG4637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3410
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323393at33208
OrthoFinder	1	1.000	-	-		FOG0001513
OrthoInspector	1	1.000	-	-		otm44522
orthoMCL	1	0.900	-	-		OOG6_103810
Panther	1	1.100	-	-	O	PTHR10155
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1082
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760