DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K21B and Pik3r2

DIOPT Version :9

Sequence 1:NP_001259817.1 Gene:Pi3K21B / 33203 FlyBaseID:FBgn0020622 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_032867.2 Gene:Pik3r2 / 18709 MGIID:1098772 Length:722 Species:Mus musculus


Alignment Length:450 Identity:155/450 - (34%)
Similarity:215/450 - (47%) Gaps:88/450 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 APGSLVDPNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS-MKGEYTLTLMKDGCEKL 68
            :|.||.|        |.||||.|||||....|...|||:||||||.| ::|||||||.|.|..||
Mouse   315 SPPSLQD--------AEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKL 371

  Fly    69 IKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPHGDLCL 133
            ||:.|.|..|||.|...|.||||:|::|:..||:.||..||..|..|:.:.::|:         :
Mouse   372 IKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQ---------V 427

  Fly   134 LSNEFIRTC-QLLQNLEQNLENKRNSFNAIRE-------ELQEKKLHQSVFGNTEKIFRNQIKLN 190
            :..:.|... ..|:...|..::|...::.:.|       |||.|:.....|..|.|||..|.:..
Mouse   428 VKEDSIEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQ 492

  Fly   191 ESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVLNHYMEN 255
            |...|...:                       ..||...| |:....||::.:.|.::...:...
Mouse   493 EKCSKEYLE-----------------------RFRREGNE-KEMQRILLNSERLKSRIAEIHESR 533

  Fly   256 KKKEELL---------LERQINALKPELQILQLRKDKYIERLKGFNLKDDDLKMILQMG-----F 306
            .|.|:.|         :::::|:|||:|  :||||           ::|..|..:.|.|     .
Mouse   534 TKLEQDLRAQASDNREIDKRMNSLKPDL--MQLRK-----------IRDQYLVWLTQKGARQRKI 585

  Fly   307 DKWQQLYETVSNQ----------PHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYA 360
            ::|..:.....:|          ||..|..|.:....|..|||||.|...|||||| :...|.||
Mouse   586 NEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYA 650

  Fly   361 LSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420
            .|:......:||:||.|:||||||.|||:|.:||.||.||.:.||.:|||.||.||..||
Mouse   651 CSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K21BNP_001259817.1 SH2_nSH2_p85_like 14..123 CDD:198195 55/109 (50%)
PI3K_P85_iSH2 129..302 CDD:293063 38/189 (20%)
iSH2_PI3K_IA_R 138..303 CDD:304922 38/181 (21%)
SH2_cSH2_p85_like 320..422 CDD:198184 52/101 (51%)
Pik3r2NP_032867.2 SH3_PI3K_p85beta 7..80 CDD:212842
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..108
RhoGAP 111..289 CDD:295372
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..319 1/3 (33%)
SH2_nSH2_p85_like 316..426 CDD:198195 59/117 (50%)
PI3K_P85_iSH2 430..589 CDD:293063 40/195 (21%)
iSH2_PIK3R2 431..591 CDD:214019 41/196 (21%)
SH2_cSH2_p85_like 609..712 CDD:198184 52/101 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834481
Domainoid 1 1.000 94 1.000 Domainoid score I7446
eggNOG 1 0.900 - - E1_KOG4637
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 225 1.000 Inparanoid score I3488
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323393at33208
OrthoFinder 1 1.000 - - FOG0001513
OrthoInspector 1 1.000 - - otm42458
orthoMCL 1 0.900 - - OOG6_103810
Panther 1 1.100 - - O PTHR10155
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1082
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.760

Return to query results.
Submit another query.