DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K21B and vav-1

DIOPT Version :9

Sequence 1:NP_001259817.1 Gene:Pi3K21B / 33203 FlyBaseID:FBgn0020622 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_001359918.1 Gene:vav-1 / 181153 WormBaseID:WBGene00006887 Length:1007 Species:Caenorhabditis elegans


Alignment Length:532 Identity:102/532 - (19%)
Similarity:193/532 - (36%) Gaps:130/532 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 AKSILHGKPDGSFLVRDALSMKGEYTLTLMKDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYY 96
            |..::..|..|:....:..:.|..|.::.:     .:.|...:|.|.|...|.....|:.|....
 Worm   508 ANKVMAAKTTGASARTNTFTYKNAYVMSEL-----TIDKNASLDVKSGGTITRRTQYVIIMTRDR 567

  Fly    97 KENS----LSMYNKTLDITLSNPIVRAREDEESQPHGDLCLLSNEFI------------RTCQLL 145
            .||:    |:.|.|. :.|.:|.:......:.:....|....:|..:            .||.:.
 Worm   568 NENNEITQLTFYFKN-EATRNNWMTALLLSKSNVSP
TDYLRDTNHKVAFHSFRVDVKNPATCDVC 631

  Fly   146 QNLEQNLENKRNSFNAIREELQEKKLHQSVFGNTEKIFRNQIKLNESFMKAPADAPSTEAGGA-- 208
            ..|.:.|:     :...:.|.....:|:...|         :|..|:..|:..:..|:::...  
 Worm   632 DKLMKGLQ-----YQGYKCESCNMSMHKECLG---------LKKCEAVRKSTHETRSSQSFNCNR 682

  Fly   209 -------GDGANAAASAAANANARRS-----------------LQEHKQTLLNLLDALQAKGQV- 248
                   ||      ...||:|:..|                 :|.|.:....|::.....|.| 
 Worm   683 PRFHIHEGD------IVVANSNSTPSDLSYLQFAKGDRIEVIKMQGHNRFTGCLINNRNRTGLVH 741

  Fly   249 LNHYMENKKKEELLL---ERQINALKPEL----------QILQLRKDKYIERLKGFNLKDDDLKM 300
            |:|..:::....:.|   :....::.|.:          ::|.....:.:....|.....:....
 Worm   742 LDHVSQSRTTSMIGLSPIDSPAGSIAPRVVRNESTVLPNKLLSDGSSRSLSGPHGSRSSRNSSSS 806

  Fly   301 ILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYALSIA 364
            .:....|...:..:.|:.:  .:|.||.:.:.:|..||..|||.|:||||:| :::....|:|::
 Worm   807 TINGSMDSVPRQQDYVNTE--ISEFLWYMGEMERAKAESTLKGTPNGTFLVRYSKNRKQTAISLS 869

  Fly   365 CKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWP---------- 419
            .||.|:|.:|.:.|.|..:.....|:.:...||::|.:|:|.|....|.|.|:.|          
 Worm   870 YKNDVKHMIIEQNSDGKVYLDEDYIFNSTVELVQYYRSNNLIEIFAALDTCLKNPYSQCKVFKAV 934

  Fly   420 -------------VLYWKNNPLQVQMIQLQEE--------------MDLEYEQAATLRP--PPMM 455
                         .|.:|...:.|.:..:.|:              ..|.|     ::|  |...
 Worm   935 HDYDAPSPNNEGKFLSFKTGDIVVLLDTVGEDRGWWKGQVNNKSGFFPLSY-----VKPYDPATE 994

  Fly   456 GSSAPI-PTSRS 466
            |||:|: |||.|
 Worm   995 GSSSPVTPTSSS 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K21BNP_001259817.1 SH2_nSH2_p85_like 14..123 CDD:198195 19/94 (20%)
PI3K_P85_iSH2 129..302 CDD:293063 30/224 (13%)
iSH2_PI3K_IA_R 138..303 CDD:304922 28/216 (13%)
SH2_cSH2_p85_like 320..422 CDD:198184 35/125 (28%)
vav-1NP_001359918.1 CH 38..149 CDD:237981
RhoGEF 241..435 CDD:238091
PH_Vav 453..602 CDD:269930 19/99 (19%)
C1 616..657 CDD:237996 6/45 (13%)
SH3 693..746 CDD:388381 11/52 (21%)
SH2_Vav_family 825..925 CDD:198193 34/101 (34%)
SH3 927..987 CDD:214620 6/64 (9%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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