DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stip1 and STI1

DIOPT Version :9

Sequence 1:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_014670.1	Gene:	STI1 / 854192	SGDID:	S000005553	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	587	Identity:	210/587 - (35%)
Similarity:	304/587 - (51%)	Gaps:	109/587 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NELKEKGNQALSAEKFDEAVAAYTEAIALDD-QNHVLYSNRSAAFAKAGKFQEALEDAEKTIQLN 68
            :|.|::||.|.:|:.:|:|:..:|:||.:.: .||||||||||.:....||.:||.||.:.:::|
Yeast     6 DEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKIN 70

  Fly    69 PTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQG--RMETTASALSFMQSQGDI-- 129
            |:|.|||:|.|||..||.|..:|...|.:.|:.|.:|....:|  ::..|..|   .|:|.|:
Yeast    71 PSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQA---RQAQPDLGL 132

  Fly   130 --------------------PMDVDPQ------------QA------------------------ 138
                                .|..|||            ||
Yeast   133 TQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLN 197

  Fly   139 -----RSRRAP-SPPPAKPAEPPKPAEPRVEDMT----------------------EEQKNKYFA 175
                 :|...| .|..:|..|..|.|||:.:..|                      :|..:|..|
Yeast   198 MDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEA 262

  Fly   176 RKEKELGNAAYKKKDFETALKHYHAAIE-HDPTDITFYNNIAAVHFERKEYEECIKQCEKGIEVG 239
            .|||..||..||.:.|:.|::||:.|.| |  .|||:.||.||..:|:.|||..|......:|.|
Yeast   263 DKEKAEGNKFYKARQFDEAIEHYNKAWELH--KDITYLNNRAAAEYEKGEYETAISTLNDAVEQG 325

  Fly   240 RESRADFKLIAKSFARIGNTYRKLENYKQAKVYYEKAMSEHRTPEIKTSLSEVEAKIKEEERMAY 304
            ||.|||:|:|:||||||||.|.||.:.|:...||:|:::||||.:|.|.|...|.::|:.|..||
Yeast   326 REMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAY 390

  Fly   305 INPEKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDCDT 369
            :|||||||.:.:|..:|.|.|:..|||.|||.|||.|:|.:.||||||...||.:|...:.||:.
Yeast   391 VNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNK 455

  Fly   370 CIKLDEKFIKGYIRKGKILQGMQQQSKA----QAAYQKALELDPNNAEAIE----GYRQCSMNFQ 426
            .|:.|..|::.||||......:::.:.|    .||..|..|:: |.:.|.|    .|:.....||
Yeast   456 AIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVN-NGSSAREIDQLYYKASQQRFQ 519

  Fly   427 -----RNPQEVLKNAMSDPEIQQILKDPAMRMILEQMQSDPNAVKEHLQNPAIADKIMKLLESGI 486
                 ..|:|..:.||.|||:..|::||.|:.||:|.|.:|.|::||::||.:..||..|:.:||
Yeast   520 PGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGI 584

  Fly   487 IQ 488
            |:
Yeast   585 IR 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	27/63 (43%)
		TPR repeat	7..32	CDD:276809	9/24 (38%)
		TPR repeat	37..67	CDD:276809	16/29 (55%)
		TPR_11	40..103	CDD:290150	29/62 (47%)
		TPR repeat	72..100	CDD:276809	12/27 (44%)
		TPR_11	175..237	CDD:290150	27/62 (44%)
		TPR repeat	175..203	CDD:276809	13/27 (48%)
		TPR_1	181..208	CDD:278916	11/27 (41%)
		TPR_12	205..278	CDD:290160	36/72 (50%)
		TPR repeat	208..238	CDD:276809	12/29 (41%)
		TPR repeat	250..278	CDD:276809	15/27 (56%)
		TPR_1	250..>276	CDD:278916	14/25 (56%)
		TPR_11	309..375	CDD:290150	31/65 (48%)
		TPR repeat	310..338	CDD:276809	13/27 (48%)
		TPR_1	<317..343	CDD:278916	14/25 (56%)
		TPR repeat	343..373	CDD:276809	13/29 (45%)
		TPR_1	378..411	CDD:278916	9/36 (25%)
		TPR repeat	378..406	CDD:276809	8/31 (26%)
		STI1	439..478	CDD:128966	17/38 (45%)
STI1	NP_014670.1	PLN03088	5..>106	CDD:215568	44/99 (44%)
		TPR repeat	5..33	CDD:276809	10/26 (38%)
		TPR repeat	39..69	CDD:276809	16/29 (55%)
		TPR repeat	74..102	CDD:276809	12/27 (44%)
		STI1	138..193	CDD:407696	6/54 (11%)
		3a0801s09	203..>573	CDD:273380	147/372 (40%)
		TPR repeat	262..290	CDD:276809	13/27 (48%)
		TPR repeat	294..324	CDD:276809	12/29 (41%)
		TPR repeat	336..363	CDD:276809	15/26 (58%)
		PLN03088	396..>549	CDD:215568	57/153 (37%)
		TPR repeat	396..424	CDD:276809	13/27 (48%)
		TPR repeat	429..459	CDD:276809	13/29 (45%)
		TPR repeat	464..490	CDD:276809	5/25 (20%)
		STI1	527..581	CDD:407696	24/53 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344098
Domainoid	1	1.000	56	1.000	Domainoid score	I2705
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4965
Inparanoid	1	1.050	271	1.000	Inparanoid score	I598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001589
OrthoInspector	1	1.000	-	-		oto99577
orthoMCL	1	0.900	-	-		OOG6_102012
Panther	1	1.100	-	-	LDO	PTHR22904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1407
SonicParanoid	1	1.000	-	-		X2280
TreeFam	1	0.960	-	-
	14	13.780