DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stip1 and Hop3

DIOPT Version :9

Sequence 1:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001031620.1	Gene:	Hop3 / 826849	AraportID:	AT4G12400	Length:	558	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	225/555 - (40%)
Similarity:	322/555 - (58%)	Gaps:	72/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTIQLNPT 70
            |.|.|||.|.|:..:..|:..:||||.|...||:|||||||::|...:::|||.||:|||:|.|.
plant     4 EAKSKGNAAFSSGDYATAITHFTEAINLSPTNHILYSNRSASYASLHRYEEALSDAKKTIELKPD 68

  Fly    71 WPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQGRMETTASALS-------------- 121
            |.|||||.|||..||:.|.:|.::|.:||:.||:|.:|..|..:.:.|.:|
plant    69 WSKGYSRLGAAFIGLSKFDEAVDSYKKGLEIDPSNEMLKSGLADASRSRVSSKSNPFVDAFQGKE 133

  Fly   122 -------------------FMQSQGDI---PMDVDPQQARSR---------------RAPSPPPA 149
                               |:::..:|   |.:::......|               .:......
plant   134 MWEKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLYMKDKRVMKALGVLLNVKFGGSSGEDTEM 198

  Fly   150 KPAEPPKPAEPRVE--DMTEEQKNKYFARKEKEL-----GNAAYKKKDFETALKHYHAAIEHDPT 207
            |.|:..|..||.:|  ::|||::.|. .||||.|     ||.|||||||..|::||..|:|.|..
plant   199 KEADERKEPEPEMEPMELTEEERQKK-ERKEKALKEKGEGNVAYKKKDFGRAVEHYTKAMELDDE 262

  Fly   208 DITFYNNIAAVHFERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARIGNTYRKL----ENYKQ 268
            ||::..|.|||:.|..:|||||:.|:|.:|.|||.|:|||:||::..|.|:...|:    ::::.
plant   263 DISYLTNRAAVYLEMGKYEECIEDCDKAVERGRELRSDFKMIARALTRKGSALVKMARCSKDFEP 327

  Fly   269 AKVYYEKAMSEHRTPEIKTSLSEVEAKIKEEERMAYINPEKAEEEKEQGNLFFKKGDYSTAVKHY 333
            |...::||::|||.|:....|::.|...||.|:..|.:|..||||:|:||.|||:..|..|||||
plant   328 AIETFQKALTEHRNPDTLKKLNDAEKVKKELEQQEYFDPTIAEEEREKGNGFFKEQKYPEAVKHY 392

  Fly   334 TEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDCDTCIKLDEKFIKGYIRKGKILQGMQQQSKAQ 398
            :|||||||:|.:.|||||||||||.|...||||.:.||:||..|.|||.|||.|...|::..||.
plant   393 SEAIKRNPNDVRAYSNRAACYTKLGALPEGLKDAEKCIELDPSFTKGYSRKGAIQFFMKEYDKAM 457

  Fly   399 AAYQKALELDPNNAEAIEGYRQCSMNFQR------NPQEVLK---NAMSDPEIQQILKDPAMRMI 454
            ..||:.|:.||.|.|.::|.|:|.....:      .|:|:.:   .||.|||:|.||.||.||.:
plant   458 ETYQEGLKHDPKNQEFLDGVRRCVEQINKASRGDLTPEELKERQAKAMQDPEVQNILSDPVMRQV 522

  Fly   455 LEQMQSDPNAVKEHLQNPAIADKIMKLLESGIIQI 489
            |...|.:|.|.:||::||.:.:||.||:.:||:|:
plant   523 LVDFQENPKAAQEHMKNPMVMNKIQKLVSAGIVQV 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	32/62 (52%)
		TPR repeat	7..32	CDD:276809	10/24 (42%)
		TPR repeat	37..67	CDD:276809	18/29 (62%)
		TPR_11	40..103	CDD:290150	34/62 (55%)
		TPR repeat	72..100	CDD:276809	14/27 (52%)
		TPR_11	175..237	CDD:290150	34/66 (52%)
		TPR repeat	175..203	CDD:276809	18/32 (56%)
		TPR_1	181..208	CDD:278916	16/31 (52%)
		TPR_12	205..278	CDD:290160	31/76 (41%)
		TPR repeat	208..238	CDD:276809	14/29 (48%)
		TPR repeat	250..278	CDD:276809	7/31 (23%)
		TPR_1	250..>276	CDD:278916	5/29 (17%)
		TPR_11	309..375	CDD:290150	43/65 (66%)
		TPR repeat	310..338	CDD:276809	18/27 (67%)
		TPR_1	<317..343	CDD:278916	18/25 (72%)
		TPR repeat	343..373	CDD:276809	19/29 (66%)
		TPR_1	378..411	CDD:278916	15/32 (47%)
		TPR repeat	378..406	CDD:276809	12/27 (44%)
		STI1	439..478	CDD:128966	18/38 (47%)
Hop3	NP_001031620.1	TPR_11	2..67	CDD:290150	32/62 (52%)
		TPR repeat	2..30	CDD:276809	11/25 (44%)
		TPR repeat	35..65	CDD:276809	18/29 (62%)
		TPR_11	38..101	CDD:290150	34/62 (55%)
		TPR_1	70..103	CDD:278916	17/32 (53%)
		TPR repeat	70..98	CDD:276809	14/27 (52%)
		TPR_11	229..292	CDD:290150	31/62 (50%)
		TPR repeat	234..258	CDD:276809	13/23 (57%)
		TPR repeat	263..293	CDD:276809	14/29 (48%)
		TPR_12	264..337	CDD:290160	29/72 (40%)
		TPR_1	267..292	CDD:278916	12/24 (50%)
		TPR repeat	305..336	CDD:276809	6/30 (20%)
		TPR_11	369..434	CDD:290150	43/64 (67%)
		TPR repeat	369..397	CDD:276809	18/27 (67%)
		TPR_1	375..402	CDD:278916	18/26 (69%)
		TPR_11	402..468	CDD:290150	35/65 (54%)
		TPR repeat	402..432	CDD:276809	19/29 (66%)
		TPR_1	403..436	CDD:278916	20/32 (63%)
		TPR repeat	437..465	CDD:276809	12/27 (44%)
		TPR_1	438..470	CDD:278916	15/31 (48%)
		STI1	507..546	CDD:128966	18/38 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3894
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4965
Inparanoid	1	1.050	391	1.000	Inparanoid score	I497
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933764at2759
OrthoFinder	1	1.000	-	-		FOG0001589
OrthoInspector	1	1.000	-	-		otm3416
orthoMCL	1	0.900	-	-		OOG6_102012
Panther	1	1.100	-	-	LDO	PTHR22904
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830